ChemicalBook > CAS DataBase List > 2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine

Product Name
2'-Fluoro-2'-deoxyuridine
CAS No.
784-71-4
Chemical Name
2'-Fluoro-2'-deoxyuridine
Synonyms
2'-FU;2-FdU;2'-FUDR;2'-F-2'-dU;Fioluridine;2'-FLUORO-D-URIDINE;2'-Fluoro-2'-deoxyur;2'-F-2'-deoxyuridine;2'-F-2'-deoxyuridine;2 '- Fluorodeoxyuridine
CBNumber
CB3358175
Molecular Formula
C9H11FN2O5
Formula Weight
246.19
MOL File
784-71-4.mol
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2'-Fluoro-2'-deoxyuridine Property

Melting point:
147.0 to 153.0 °C
Density 
1.63±0.1 g/cm3(Predicted)
refractive index 
53 ° (C=0.3, H2O)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in methanol.
form 
Powder
pka
9.39±0.10(Predicted)
color 
White to Off-white
optical activity
α20/D +53°±3°, c = 0.3 in water
Water Solubility 
soluble in water
InChI
InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChIKey
UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference
784-71-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
22-36/37/39
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3615
Product name
2'-Deoxy-2'-fluorouridine
Purity
>97.0%(HPLC)
Packaging
1g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
D3615
Product name
2'-Deoxy-2'-fluorouridine
Purity
>97.0%(HPLC)
Packaging
5g
Price
$121
Updated
2024/03/01
Alfa Aesar
Product number
J65948
Product name
2'-Fluoro-2'-deoxyuridine, 97%
Packaging
1g
Price
$28.65
Updated
2024/03/01
Alfa Aesar
Product number
J65948
Product name
2'-Fluoro-2'-deoxyuridine, 97%
Packaging
5g
Price
$104.65
Updated
2024/03/01
Alfa Aesar
Product number
J65948
Product name
2'-Fluoro-2'-deoxyuridine, 97%
Packaging
25g
Price
$405.65
Updated
2024/03/01
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2'-Fluoro-2'-deoxyuridine Chemical Properties,Usage,Production

Description

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

Chemical Properties

White to almost white crystalline powder

Uses

2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Uses

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Synthesis

Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.

2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Fluoro-2'-deoxyuridine Suppliers

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View Lastest Price from 2'-Fluoro-2'-deoxyuridine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.
Product
2'-Deoxy-2'-fluorouridine 784-71-4
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20Ton
Release date
2024-11-01
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2'-Fluoro-2'-Deoxyuridine 784-71-4
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5ton
Release date
2024-04-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2'-Fluoro-2'-deoxyuridine 784-71-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-08

784-71-4, 2'-Fluoro-2'-deoxyuridineRelated Search:

Trifluridine 2'-Deoxyuridine Doxifluridine 2'-DEOXY-2'-FLUOROTHYMIDINE 5-Fluoro-2'-deoxyuridine 98%,(+)-5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2-DEOXYURIDINE,beta-5-fluoro-2’-deoxyuridin uridine diphosphate glucose {= UDP-glucose} BrdU (Bromodeoxyuridine) Fluorine DMT-2′Fluoro-dU Phosphoramidite Uridine 2',2'-DIFLUORO-2'-DEOXYURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-FLUORODEOXYURIDINE-5,6-D2 2'-FLUORO-2'DEOXYURIDINE, [5'-3H] 2',2'-DIFLUORO-2'-DEOXYURIDINE 13C, 15N2 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 5-FLUORO 2'-DEOXYURIDINE, [6-3H]-,5'-FLUORO-2'DEOXYURIDINE, [6-3H] 3',5'-DI-O-ACETYL-5-FLUORO-2'-DEOXYURIDINE

  • 1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL
  • 2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL)
  • 2'-FLUORO-2'-DEOXYURIDINE
  • 2'-FLUORO-2'-DESOXY-URIDINE
  • 2'-DEOXY-2'-FLUOROURIDINE
  • 2'-FLUORO-D-URIDINE
  • 2'-FUDR
  • 2'-FU
  • 2'-DEOXY-2'-FLUOROURIDINE (2'-FLUORO-2'- DEOXYURIDINE, 2'-FU)
  • 2'-Deoxy-2'-fluoro-D-uridine
  • 2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE)
  • URIDINE,2''-DEOXY-2''-FLUORO
  • 2-FdU
  • 2'-Fluoro-5'-O-DMT-2'-deoxyuridine
  • 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
  • 2'-Fluoro-2'-deoxyur
  • Fioluridine
  • FN-011 2'-Fluoro-2'-deoxyuridine
  • 2'-Deoxy-2'-fluorouridine≥ 97% (HPLC)
  • 2'-Fluoro-2'-deoxyuridine 98%
  • 2'-Deoxy-2'-fluorouridine, 98.0%
  • Uridine Impurity 19 （2'-Fluoro-2'-deoxyuridine）
  • 2'-Deoxy-2'-fluorouridine&gt
  • 2'-F-2'-dU
  • 2'-Fluoro-2'-deoxyuridine USP/EP/BP
  • 2'-F-2'-deoxyuridine
  • inhibit,2' Deoxy 2' fluorouridine,Inhibitor,antiinfluenza virus,influenza,Influenza Virus,intermediate,2'Deoxy2'fluorouridine
  • 2 '- Fluorodeoxyuridine
  • 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  • 2'-Fluoro-2'-Deoxyuridine (FdU)
  • 2'-Deoxy-2'-fluorouridine
  • 2'-Fluoro-2'-deoxyuridine
  • 2'-F-2'-deoxyuridine
  • 784-71-4
  • 781-71-4
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • API intermediates
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Pyridines, Pyrimidines, Purines and Pteredines
  • 784-71-4
  • Nucleosides
  • Modified（deoxy）nucleoside
  • Nucleosides-2'-F Nucleosides
  • 1