Cbz-Cyclohexyl-L-glycine

Product Name: Cbz-Cyclohexyl-L-glycine
CAS No.: 69901-75-3
Chemical Name: Cbz-Cyclohexyl-L-glycine
Synonyms: Z-CHG-OH;Cbz-CycL;CBZ-CHG-OH;Z-L-Chg-OH;Cbz-L-CHG-OH;Z-CYCLOHEXYL-GLY-OH;Z-Cyclohexylglycine;Z-PHG(HEXAHYDRO)-OH;Z-L-CYCLOHEXYLGLYCINE;Z-L-cyclohexyl-Gly-OH
CBNumber: CB3362020
Molecular Formula: C16H21NO4
Formula Weight: 291.35
MOL File: 69901-75-3.mol

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Cbz-Cyclohexyl-L-glycine Property

Melting point:: 111-114°C
Boiling point:: 492.1±38.0 °C(Predicted)
Density: 1.200±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.99±0.10(Predicted)
color: White
InChI: InChI=1/C16H21NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1,3-4,7-8,13-14H,2,5-6,9-11H2,(H,17,20)(H,18,19)/t14-/s3
InChIKey: CUSYTUPJAYLNFQ-WDHUHKLTNA-N
SMILES: [C@H](C1CCCCC1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 |&1:0,r|
LogP: 1.7 at 25℃ and pH2.5
CAS DataBase Reference: 69901-75-3(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C227500
Product name: Cbz-Cyclohexyl-L-glycine
Packaging: 50g
Price: $435
Updated: 2021/12/16

Usbiological

Product number: 242739
Product name: Z-L-2-cyclohexylglycine
Packaging: 1g
Price: $193
Updated: 2021/12/16

ChemScene

Product number: CS-M2257
Product name: (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylaceticacid
Purity: 99.95%
Packaging: 100g
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19841
Product name: Cbz-cyclohexyl-L-glycine
Packaging: 100g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19841
Product name: Cbz-cyclohexyl-L-glycine
Packaging: 25g
Price: $70
Updated: 2021/12/16

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Cbz-Cyclohexyl-L-glycine Chemical Properties,Usage,Production

Chemical Properties

Cbz-Cyclohexyl-L-glycine is white to Off-White Solid

Uses

Cbz-Cyclohexyl-L-glycine is a gylicine derivative used in the preparation of peptides as inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease.

Synthesis

14328-51-9

501-53-1

69901-75-3

General Steps: Step (1): 534 mL of deionized water and 60.9 mL of 20% aqueous sodium hydroxide were added to 60.0 g of L-(+)-2-cyclohexylglycine (L-CHG) and stirred until completely dissolved. Subsequently, activated carbon was added to the solution for decolorization and supplemented with 79 mL of deionized water. Under stirring, 65.1 g of benzyl chloroformate (Cbz-Cl) and 60.9 mL of 20% aqueous sodium hydroxide solution were added slowly and dropwise to introduce a benzyloxycarbonyl (Cbz) protecting group in the L-CHG molecule. Step (2): the reaction solution obtained in step (1) (total volume 865 mL) was added to deionized water and isopropyl alcohol (IPA) in the proportions shown in Table 1, respectively. Step (3): After the completion of step (2), 4.1 mL of hydrochloric acid was added to the reaction solution to carry out the neutralization reaction, and the precipitated crystals were subsequently separated by filtration. The crystals obtained by filtration were dried to finally obtain (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid (Cbz-L-CHG). The specific results for each experimental condition are detailed in Table 1.

References

[1] Patent: US2011/152573, 2011, A1. Location in patent: Page/Page column 3

Cbz-Cyclohexyl-L-glycine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cbz-Cyclohexyl-L-glycine Suppliers

Canada 2 China 168 France 1 Germany 2 India 3 Japan 2 Switzerland 1 United Kingdom 2 United States 14 Global 195

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View Lastest Price from Cbz-Cyclohexyl-L-glycine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cbz-Cyclohexyl-L-glycine 69901-75-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-Chg-OH 69901-75-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-05

Hangzhou ICH Biofarm Co., Ltd

Product: Cbz-Cyclohexyl-L-glycine 69901-75-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 100kg
Release date: 2023-06-30

69901-75-3, Cbz-Cyclohexyl-L-glycineRelated Search:

N-Carbobenzyloxyglycine Trimethoprim Isocyanatocyclohexane Benzyloxyacetyl chloride Stearic acid Folic acid Ethyl 2-(Chlorosulfonyl)acetate Molasses Glycine Cyclohexylbenzene Betaine Benzyl glycinate hydrochloride Cyclohexanemethanol Z-3-CYCLOHEXYL-L-ALANINE Citric acid Ascoric Acid N-Cbz-L-Isoleucine Z-NLE-OH

Cyclohexaneacetic acid,a-[[(phenylMethoxy)carbonyl]aMino]-,(aS)-

Cbz-L-CHG-OH

CBZ-CHG-OH

N-Benzyloxycarbonyl-L-2-cyclohexylglycine, 95%

(S)-N-Cbz-Aminocyclohexylacetic acid

Cbz-Cyclohexyl-L-glycine

Z-Cyclohexylglycine

(S)-α-[[(phenylMethoxy)carbonyl]aMino]cyclohexaneacetic Acid

(αS)-α-[[(PhenylMethoxy)carbonyl]aMino]cyclohexaneacetic Acid

Z-CHG-OH

Z-CYCLOHEXYL-GLY-OH

Z-L-2-CYCLOHEXYLGLYCINE

Z-L-CYCLOHEXYLGLYCINE

Z-PHG(HEXAHYDRO)-OH

(S)-CBZ-CYCLOHEXYLGLYCINE

N-ALPHA-CARBOBENZOXY-L-CYCLOHEXYLGLYCINE

N-ALPHA-CARBOBENZOXY-HEXAHYDRO-L-PHENYLGLYCINE

CBZ-L-CYCLOHEXYLGLYCINE

(S)-2-(benzyloxycarbonylamino)-2-cyclohexylacetic acid

(2S)-2-{[(benzyloxy)carbonyl]amino}-2-cyclohexylacetic acid

N-Cbz-alpha-cyclohexyl-L-glycine

Z-L-Chg-OH

Z-L-cyclohexyl-Gly-OH

Cyclohexaneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, (αS)-

Cbz-cyclohexyl-L-glycine (terprovir intermediate)

2-cyclohexyl-3-oxo-3-phenylmethoxypropanoic acid

Cbz-CycL

(S)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylaceticaci

(S)-2-cyclohexyl-2-((ethoxycarbonyl)amino)acetic acid

Cbz-Cyclohexyl-L-glycine USP/EP/BP

69901-75-3 Cbz-Cyclohexyl-L-glycine

N-Benzyloxycarbonyl-L-2- cyclohexylgl

(2S)-[[(benzyloxy)carbonyl]amino](cyclohexyl)acetic acid

69901-75-3

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