Cbz-Cyclohexyl-L-glycine
- Product Name
- Cbz-Cyclohexyl-L-glycine
- CAS No.
- 69901-75-3
- Chemical Name
- Cbz-Cyclohexyl-L-glycine
- Synonyms
- Z-CHG-OH;Cbz-CycL;CBZ-CHG-OH;Z-L-Chg-OH;Cbz-L-CHG-OH;Z-CYCLOHEXYL-GLY-OH;Z-Cyclohexylglycine;Z-PHG(HEXAHYDRO)-OH;Z-L-CYCLOHEXYLGLYCINE;Z-L-cyclohexyl-Gly-OH
- CBNumber
- CB3362020
- Molecular Formula
- C16H21NO4
- Formula Weight
- 291.35
- MOL File
- 69901-75-3.mol
Cbz-Cyclohexyl-L-glycine Property
- Melting point:
- 111-114°C
- Boiling point:
- 492.1±38.0 °C(Predicted)
- Density
- 1.200±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.99±0.10(Predicted)
- color
- White
- InChI
- InChI=1/C16H21NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1,3-4,7-8,13-14H,2,5-6,9-11H2,(H,17,20)(H,18,19)/t14-/s3
- InChIKey
- CUSYTUPJAYLNFQ-WDHUHKLTNA-N
- SMILES
- [C@H](C1CCCCC1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 |&1:0,r|
- LogP
- 1.7 at 25℃ and pH2.5
- CAS DataBase Reference
- 69901-75-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C227500
- Product name
- Cbz-Cyclohexyl-L-glycine
- Packaging
- 50g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- 242739
- Product name
- Z-L-2-cyclohexylglycine
- Packaging
- 1g
- Price
- $193
- Updated
- 2021/12/16
- Product number
- CS-M2257
- Product name
- (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylaceticacid
- Purity
- 99.95%
- Packaging
- 100g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FC19841
- Product name
- Cbz-cyclohexyl-L-glycine
- Packaging
- 100g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FC19841
- Product name
- Cbz-cyclohexyl-L-glycine
- Packaging
- 25g
- Price
- $70
- Updated
- 2021/12/16
Cbz-Cyclohexyl-L-glycine Chemical Properties,Usage,Production
Chemical Properties
Cbz-Cyclohexyl-L-glycine is white to Off-White Solid
Uses
Cbz-Cyclohexyl-L-glycine is a gylicine derivative used in the preparation of peptides as inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease.
Synthesis
14328-51-9
501-53-1
69901-75-3
General Steps: Step (1): 534 mL of deionized water and 60.9 mL of 20% aqueous sodium hydroxide were added to 60.0 g of L-(+)-2-cyclohexylglycine (L-CHG) and stirred until completely dissolved. Subsequently, activated carbon was added to the solution for decolorization and supplemented with 79 mL of deionized water. Under stirring, 65.1 g of benzyl chloroformate (Cbz-Cl) and 60.9 mL of 20% aqueous sodium hydroxide solution were added slowly and dropwise to introduce a benzyloxycarbonyl (Cbz) protecting group in the L-CHG molecule. Step (2): the reaction solution obtained in step (1) (total volume 865 mL) was added to deionized water and isopropyl alcohol (IPA) in the proportions shown in Table 1, respectively. Step (3): After the completion of step (2), 4.1 mL of hydrochloric acid was added to the reaction solution to carry out the neutralization reaction, and the precipitated crystals were subsequently separated by filtration. The crystals obtained by filtration were dried to finally obtain (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid (Cbz-L-CHG). The specific results for each experimental condition are detailed in Table 1.
References
[1] Patent: US2011/152573, 2011, A1. Location in patent: Page/Page column 3
Cbz-Cyclohexyl-L-glycine Preparation Products And Raw materials
Raw materials
Preparation Products
Cbz-Cyclohexyl-L-glycine Suppliers
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- Country
- United Kingdom
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View Lastest Price from Cbz-Cyclohexyl-L-glycine manufacturers
- Product
- Cbz-Cyclohexyl-L-glycine 69901-75-3
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-08-28
- Product
- Cbz-Chg-OH 69901-75-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-05
- Product
- Cbz-Cyclohexyl-L-glycine 69901-75-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 97%
- Supply Ability
- 100kg
- Release date
- 2023-06-30