tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

Product Name: tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
CAS No.: 3392-12-9
Chemical Name: tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
Synonyms: 2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate;BOC-VAL-OSU;BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER;(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;￥545,287.00;Boc-Val-ONSu;BOC-VALINE-OSU;Boc-L-Val-ONSu;Boc-Val-succinimide;Boc-Val-OSu >=98.5% (N)
CBNumber: CB3363294
Molecular Formula: C14H22N2O6
Formula Weight: 314.33
MOL File: 3392-12-9.mol

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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Property

Melting point:: 126-128 °C
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: -20°C
pka: 10.72±0.46(Predicted)
form: Powder
color: White to off-white
optical activity: [α]20/D 38±1°, c = 2% in dioxane
Sensitive: Moisture Sensitive
BRN: 1551859
CAS DataBase Reference: 3392-12-9(CAS DataBase Reference)

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Safety

WGK Germany: 3
F: 3-10-21
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15531
Product name: Boc-Val-OSu
Purity: ≥98.5% (N)
Packaging: 5g
Price: $75.6
Updated: 2025/07/31

Usbiological

Product number: 264806
Product name: Boc-L-valine N-hydroxysuccinimide ester
Packaging: 25g
Price: $366
Updated: 2021/12/16

Iris Biotech GmbH

Product number: BAA6040
Product name: Boc-L-Val-OSu
Packaging: 100g
Price: $371.25
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47750
Product name: Boc-L-valine N-hydroxysuccinimide ester
Packaging: 250g
Price: $430
Updated: 2021/12/16

Chem-Impex

Product number: 03675
Product name: Boc-L-valineN-hydroxysuccinimideester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 250G
Price: $526.68
Updated: 2021/12/16

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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

6066-82-6

13734-41-3

3392-12-9

Step A: Boc-L-valine (1.03 g, 4.74 mmol), N-hydroxysuccinimide (1.22 g, 10.6 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 1.60 g, 8.35 mmol) were sequentially added to a dry round-bottom flask. The above reagents were dissolved in anhydrous dichloromethane (30 mL), and the reaction system was sealed through a rubber septum and displaced three times with argon to exclude oxygen. Subsequently, the reaction mixture was stirred at room temperature.After 3 days, thin layer chromatography (TLC) detection (ninhydrin color development) confirmed that the Boc-L-valine was fully reacted. The reaction solution was washed sequentially with water, saturated aqueous sodium bicarbonate, and the aqueous phase was back-extracted with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried under vacuum to obtain white solid Boc-L-valine hydroxysuccinimide ester (1.52 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.98 (broad peak, 1H), 4.58 (double peak, 1H), 2.82 (multiple peaks, 4H), 2.27 (multiple peaks, 1H), 1.44 (single peak, 9H), 1.03 (double peaks, 6H).

References

[1] Patent: WO2016/160615, 2016, A1. Location in patent: Paragraph 0444; 0445
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2461 - 2480
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2852 - 2857
[4] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984, p. 2305 - 2308
[5] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4580 - 4585

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Suppliers

China 106 Germany 3 Hungary 1 India 1 Japan 2 Switzerland 3 United Kingdom 5 United States 21 Global 142

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View Lastest Price from tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: tert-Butoxycarbonyl-L-valine 3392-12-9
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

Career Henan Chemical Co

Product: tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-15

Career Henan Chemical Co

Product: tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

3392-12-9, tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide esterRelated Search:

PYRAZOPHOS 1,1'-Carbonyldiimidazole O-Phthalimide Dibutyl phthalate Dimethyl succinate L-Valine Methyl acrylate Cyhalofop-butyl Butyl acetate Maleimide Bismaleimide Valine CARBONYL SULFIDE tert-Butanol Tris(trimethylsilyl)phosphate BUTYL OLEATE Succinimide Diethylene glycol monobutyl ether

BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER

BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER

BOC-VAL-OSU

BOC-VALINE-OSU

N-ALPHA-T-BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER

N-BOC-L-VAL-N-HYDROXYSUCCINIMIDE

N-TERT-BUTOXYCARBONYL-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER

tert-butyl (S)-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-methylpropyl]carbamate

BOC-L-VALINE HYDROXYSUCCINIMIDESTER

N-(tert-butoxycarbonyl)-L-valine hydroxysuccinimide ester

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

[(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

Boc-L-Val-ONSu

N-(tert-Butoxycarbonyl)-L-valine succinimidyl ester

(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate

L-Valine, N-[(1,1-diMethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester

Boc-Val-OSu >=98.5% (N)

￥545,287.00

Boc-Val-ONSu

Boc-Val-succinimide

Boc-L-valineN-hydroxysuccinimide ester≥ 99% (HPLC)

N-Boc-L-valine N-succinimidyl ester

(Tert-Butoxy)Carbonyl Val-Osu

(2,5-Dioxopyrrolidin-1-yl) (2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoate

(2,5-dioxopyrrolidin-1-yl)(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester USP/EP/BP

2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate

tert-Butoxycarbonyl-L-valine

3392-12-9

545-28-7

545287

C14H22N2O6

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Valine

Amino Acid Derivatives

Amino Acid