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Caulophylline

Product Name
Caulophylline
CAS No.
486-86-2
Chemical Name
Caulophylline
Synonyms
(1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;N-Methylcytisine-RM;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P)
CBNumber
CB3366194
Molecular Formula
C12H16N2O
Formula Weight
204.27
MOL File
486-86-2.mol
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Caulophylline Property

Melting point:
137-139oC
alpha 
30D -224° (c = 1.05 in water)
Boiling point:
342.77°C (rough estimate)
Density 
1.0565 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
powder
pka
9.61±0.20(Predicted)
color 
White to Off-White
NIST Chemistry Reference
Caulophylline(486-86-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
HA4400000
Toxicity
LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00353
Product name
N-Methylcytisine
Purity
≥98% (HPLC)
Packaging
5mg
Price
$197
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL83219
Product name
N-Methylcytisine
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$574
Updated
2024/03/01
Sigma-Aldrich
Product number
CDS010442
Product name
N-Methylcytisine
Purity
AldrichCPR
Packaging
25mg
Price
$308
Updated
2023/06/20
TRC
Product number
M294680
Product name
N-Methylcytisine
Packaging
25mg
Price
$135
Updated
2021/12/16
Usbiological
Product number
M3398-60
Product name
N-Methylcytisine
Packaging
25mg
Price
$460
Updated
2021/12/16
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Caulophylline Chemical Properties,Usage,Production

Description

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]20D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemical Properties

Colourless Needles

Uses

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

General Description

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

Biochem/physiol Actions

N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.

References

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

Caulophylline Preparation Products And Raw materials

Raw materials

Preparation Products

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Caulophylline Suppliers

Canada 1 China 177 Europe 1 Germany 2 India 1 United States 21 Global 203
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Caulophylline manufacturers

Shanghai Standard Technology Co., Ltd.
Product
N-Methylcytisine 486-86-2
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-11
Career Henan Chemical Co
Product
Caulophylline 486-86-2
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

486-86-2, CaulophyllineRelated Search:

N,N-Dimethylformamide 1-Methylimidazole CYTISINE N-Methyl-2-pyrrolidone Sodium carboxymethyl cellulose (-)-SPARTEINE 1-Methylpyrrolidine 2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI) L-N-METHYLEPHEDRINE HYDROCHLORIDE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE (-)-N-METHYLEPHEDRINE ANAGYRINE Caulophylline hydriodide Caulophylline 3-(2-AMINO-ACETYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE 3-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE AKOS 213-126 3-(2-AMINO-4-METHYLSULFANYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

  • N-METHYLCYTISINE
  • (1r)-l
  • 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)-
  • 12-methyl-cytisin
  • 12-Methylcytisine
  • Caulophyllin
  • Caulophylline
  • Cytisine, 12-methyl-
  • (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
  • (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
  • (1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
  • [1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
  • METHYLCYTISINE, N-(P)
  • N-Methylcytisine AldrichCPR
  • Methylcytisine
  • N-Methylcytisine hydrobromide
  • N-Methylcytisine, 98%, from Sophora flavescens Aiton
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)-
  • Caulophylline USP/EP/BP
  • (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]...
  • (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one
  • Caulophylline (N-Methylcytisine)
  • N-Methylcytisine-RM
  • 486-86-2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Miscellaneous Reagents
  • standardized herbal extract