Caulophylline

Product Name: Caulophylline
CAS No.: 486-86-2
Chemical Name: Caulophylline
Synonyms: (1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P);Caulophylline USP/EP/BP
CBNumber: CB3366194
Molecular Formula: C12H16N2O
Formula Weight: 204.27
MOL File: 486-86-2.mol

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Caulophylline Property

Melting point:: 137-139oC
alpha: 30D -224° (c = 1.05 in water)
Boiling point:: 342.77°C (rough estimate)
Density: 1.0565 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: powder
pka: 9.61±0.20(Predicted)
color: White to Off-White
NIST Chemistry Reference: Caulophylline(486-86-2)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: HA4400000
Toxicity: LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00353
Product name: N-Methylcytisine
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $197
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL83219
Product name: N-Methylcytisine
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $574
Updated: 2024/03/01

Sigma-Aldrich

Product number: CDS010442
Product name: N-Methylcytisine
Purity: AldrichCPR
Packaging: 25mg
Price: $308
Updated: 2023/06/20

Usbiological

Product number: M3398-60
Product name: N-Methylcytisine
Packaging: 25mg
Price: $460
Updated: 2021/12/16

TRC

Product number: M294680
Product name: N-Methylcytisine
Packaging: 100mg
Price: $460
Updated: 2021/12/16

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Caulophylline Chemical Properties,Usage,Production

Description

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]²⁰_D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemical Properties

Colourless Needles

Uses

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

General Description

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

Biochem/physiol Actions

N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.

References

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

Caulophylline Preparation Products And Raw materials

Raw materials

Preparation Products

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Caulophylline Suppliers

Canada 1 China 163 Europe 1 Germany 2 India 1 United States 20 Global 188

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View Lastest Price from Caulophylline manufacturers

Shanghai Standard Technology Co., Ltd.

Product: N-Methylcytisine 486-86-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-11

Career Henan Chemical Co

Product: Caulophylline 486-86-2
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

486-86-2, CaulophyllineRelated Search:

N,N-Dimethylformamide 1-Methylimidazole CYTISINE N-Methyl-2-pyrrolidone Sodium carboxymethyl cellulose (-)-SPARTEINE 1-Methylpyrrolidine 2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI) L-N-METHYLEPHEDRINE HYDROCHLORIDE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE (-)-N-METHYLEPHEDRINE ANAGYRINE Caulophylline hydriodide Caulophylline 3-(2-AMINO-ACETYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE 3-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE AKOS 213-126 3-(2-AMINO-4-METHYLSULFANYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

N-METHYLCYTISINE

(1r)-l

1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy

1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-

1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)-

12-methyl-cytisin

12-Methylcytisine

Caulophyllin

Caulophylline

Cytisine, 12-methyl-

(1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one

(1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one

(1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one

[1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one

METHYLCYTISINE, N-(P)

N-Methylcytisine AldrichCPR

Methylcytisine

N-Methylcytisine hydrobromide

N-Methylcytisine, 98%, from Sophora flavescens Aiton

1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)-

Caulophylline USP/EP/BP

(1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]...

(1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one

486-86-2

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

Miscellaneous Reagents

standardized herbal extract