Hexamethylene bisacetamide

Product Name: Hexamethylene bisacetamide
CAS No.: 3073-59-4
Chemical Name: Hexamethylene bisacetamide
Synonyms: NSC-95580;N,N′1,6-DIACETAMIDOHEXANE;1,6-Hexanebisacetamide;Hexamethylenediacetamide;hexamethylenebisacetamide;HEXAMETHYLENE BISCETAMIDE;Hexamethylene bisacetamide;N,N'-Diacetyl-1,6-hexadiamine;N-(6-acetamidohexyl)acetamide
CBNumber: CB3374289
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 3073-59-4.mol

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Hexamethylene bisacetamide Property

Melting point:: 128-129 °C(lit.)
Boiling point:: 338.01°C (rough estimate)
Density: 0.974
refractive index: 1.4710 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: water: soluble5%, clear, colorless
form: A solid
pka: 16.20±0.46(Predicted)
BRN: 1775764
InChI: InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
InChIKey: BNQSTAOJRULKNX-UHFFFAOYSA-N
SMILES: C(NC(=O)C)CCCCCNC(=O)C
CAS DataBase Reference: 3073-59-4(CAS DataBase Reference)

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Safety

Risk Statements: 33
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: AC2976200
HS Code: 29241990
Toxicity: human,TDLo,intravenous,4270mg/kg/10D (4270mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBLOOD: THROMBOCYTOPENIA,Cancer Research. Vol. 47, Pg. 5788, 1987.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 224235
Product name: N,N′-Hexamethylene bis(acetamide)
Purity: 98%
Packaging: 10g
Price: $32.4
Updated: 2023/01/07

Sigma-Aldrich

Product number: 224235
Product name: N,N′-Hexamethylene bis(acetamide)
Purity: 98%
Packaging: 50g
Price: $120
Updated: 2023/01/07

Alfa Aesar

Product number: B22771
Product name: N,N'-Diacetyl-1,6-diaminohexane
Purity: 96%
Packaging: 250g
Price: $194
Updated: 2021/12/16

Alfa Aesar

Product number: B22771
Product name: N,N'-Diacetyl-1,6-diaminohexane, 96%
Packaging: 50g
Price: $49.7
Updated: 2021/12/16

TRC

Product number: H296705
Product name: HexamethyleneBiscetamide
Packaging: 25g
Price: $45
Updated: 2021/12/16

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Hexamethylene bisacetamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder or flakes

Uses

N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.

Definition

ChEBI: N-(6-acetamidohexyl)acetamide is a member of acetamides.

Biological Activity

Hexamethylene bisacetamide is a tumor cell-differentiating agent. It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner. Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven days, but not 28, reduces tumorigenesis of those cells in mice. Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation-inducing agent. HMBA can inhibit the activation of several NF kappaB target genes in both lung and breast cancer cell lines. Furthermore, consistent with its ability to inhibit NF kappaB function, HMBA can also sensitize cells to apoptosis. HMBA mediates inhibition of the Akt and ERK/MAPK cascade, both critical for cell survival and proliferation and are well-known regulators of NF kappaB activation[1].

References

[1] Anwesha Dey. “Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.” Cell Cycle 7 23 (2008): 3759–67.

Hexamethylene bisacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexamethylene bisacetamide Suppliers

Belgium 1 China 49 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 4 United States 13 Global 73

Aladdin Scientific

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Spectrum Chemicals & Laboratory Products

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View Lastest Price from Hexamethylene bisacetamide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N,N'-DIACETYL-1,6-DIAMINOHEXANE 3073-59-4
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-18

3073-59-4, Hexamethylene bisacetamideRelated Search:

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Acetamide, N,N'-1,6-hexanediylbis-

N,N'-HEXAMETHYLENEBISACETAMIDE

N,N'-DIACETYL-1,6-DIAMINOHEXANE

N,N'-DIACETYL-1,6-HEXANEDIAMINE

1,6-Hexanebisacetamide

N,N'-(Hexane-1,6-diyl)diacetaMide

N,N'-Diacetyl-1,6-diaminohexane, 98+%

N,N'-Diacetyl-1,6-hexadiamine

N,Nμ-Diacetyl-1,6-hexanediamine, HMBA

N,N'-Hexamethylenebisacetamide,98%

N-(6-acetamidohexyl)acetamide

Acetamide, N,N'-hexamethylenebis-

Hexamethylene bisacetamide

hexamethylenebisacetamide

Hexamethylenediacetamide

n,n’-1,6-hexanediylbis-acetamid

n,n’-1,6-hexanediylbisacetamide

n,n’-diacetylhexamethylenediamine

n,n’-hexamethylenebis-acetamid

N,N'-Diacetylhexamethylenediamine

N-[6-(Acetylamino)hexyl]acetamide

NSC-95580

1,6-DIACETAMIDOHEXANE

HEXAMETHYLENE BISCETAMIDE

Inhibitor,Hexamethylene bisacetamide,HMBA,inhibit

N,N'-Diacetyl-1,6-diarninohexane

N,N'-DIACETYL-1,6-DIAMINOHEXANE

N,N'-(Hexane-1,6-diyl)diacetamide

<I>N,N&#8242

3073-59-4

C4H14O2N2

CH3CONHCH26NHCOCH3

Nitrogen Compounds

Organic Building Blocks

Protected Amines

Building Blocks