Uses
ChemicalBook > CAS DataBase List > Triisopropylsilyl chloride

Triisopropylsilyl chloride

Uses
Product Name
Triisopropylsilyl chloride
CAS No.
13154-24-0
Chemical Name
Triisopropylsilyl chloride
Synonyms
TIPSCL;CHLOROTRIISOPROPYLSILANE;TIPSCI;TRIISOPROPYLCHLOROSILANE;TriisopropyL;TISC;chlorotris(propan-2-yl)silane;Triisopropylchlorosilane (TIPSCl);DK511;SILANE IP3
CBNumber
CB3405310
Molecular Formula
C9H21ClSi
Formula Weight
192.8
MOL File
13154-24-0.mol
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Triisopropylsilyl chloride Property

Boiling point:
198 °C739 mm Hg(lit.)
Density 
0.901 g/mL at 25 °C(lit.)
vapor pressure 
1.16 mm Hg ( 20 °C)
refractive index 
n20/D 1.452(lit.)
Flash point:
145 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Sol THF, DMF, CH2Cl2.
form 
liquid
Specific Gravity
0.903
color 
colorless
Water Solubility 
Miscible with water.
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
1737446
InChIKey
KQIADDMXRMTWHZ-UHFFFAOYSA-N
CAS DataBase Reference
13154-24-0(CAS DataBase Reference)
NIST Chemistry Reference
Triisopropylsilyl chloride(13154-24-0)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-36/39
RIDADR 
UN 2987 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive
TSCA 
No
HazardClass 
8
PackingGroup 
II
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
241725
Product name
Triisopropylsilyl chloride
Purity
97%
Packaging
10g
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
241725
Product name
Triisopropylsilyl chloride
Purity
97%
Packaging
50g
Price
$288
Updated
2024/03/01
TCI Chemical
Product number
T1078
Product name
Triisopropylsilyl Chloride
Purity
>95.0%(GC)
Packaging
5mL
Price
$43
Updated
2024/03/01
TCI Chemical
Product number
T1078
Product name
Triisopropylsilyl Chloride
Purity
>95.0%(GC)
Packaging
25mL
Price
$117
Updated
2024/03/01
Alfa Aesar
Product number
A17376
Product name
Chlorotriisopropylsilane, 97+%
Packaging
10g
Price
$79.8
Updated
2024/03/01
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Triisopropylsilyl chloride Chemical Properties,Usage,Production

Uses

Triisopropyl chlorosilane has found new applications as a blocking group. It has been utilized to prepare blocked derivatives of hydroxy compounds. Derivatization of substrates is accomplished efficiently in DMF containing a slight molar excess of imidazole. Blocked intermediates exhibited acidic hydrolytic stability intermediate between that of a Tert-butyldimethylchlorosilane and Tert-butyldiphenyl chlorosilane derivatives. Greater stability was obtained with Triisopropylchlorosilane under basic conditions.

Description

Triisopropyl chlorosilane is an important sterically hindered organosilicon protective agent, which is mainly used to protect various types of hydroxyl groups, especially in polyfunctional hydroxyl compounds, which can be selectively protected and deprotected. It is very important to synthesize nucleosides, nucleotides and carbohydrates. Triisopropylchlorosilane is a good hydroxyl protecting agent, and its silanization reaction is carried out in a slight excess of imidazole solution. The acid hydrolytic stability of the protected intermediate is between TBDMS and TBDPS and the alkaline hydrolytic stability is higher than the former two.

Chemical Properties

Triisopropylsilyl chloride is colorless clear liquid

Physical properties

bp 198 °C/739 mmHg; d 0.901 g cm?3.

Uses

Chlorotriisopropylsilane is used as a silylating agent in neucleotide synthesis. It is used as an intermediate in the manufacture of chemical substances such as pharmaceuticals and in organic synthesis.

Uses

Triisopropylsilyl chloride is used as a catalyst in the preparation of (silyloxy)cyclobutene derivatives. Also used in the addition of diethylzinc to N-diphenylphosphinoyl imines.

Uses

Triisopropylsilyl Chloride is a valuable reagent for hydroxy protecting group; formation of triisopropylsilyl ynol ethers;N-protection of pyrroles; prevents chelation with Grignard reagents, including but not limited to Formation of Silyl Ynol Ethers, N-Protection of Pyrroles, Prevention of Chelation in Grignard Reactions, Protection of Terminal Alkynes, Protection of Pyrroles, Indoles, and Other Heterocycles,Preparation of “Supersilylating” Agents,Reactions with Hydrazine, Reactions with Other Nucleophiles etc.

Preparation

There are two main methods for synthesizing triisopropyl chlorosilane. One is to use triisopropyl silane as a raw material, and hydrochloric acid and other reagents are used to chlorinate the hydrogen on the silicon. Another method uses silicon tetrachloride as raw material, and reacts with isopropyl lithium to obtain triisopropyl chlorosilane.

Application

Triisopropyl chlorosilane is mainly used as a basic intermediate in the synthesis of organic silicon materials and a blocking agent for silicone oil or silicone rubber. These triisopropylchlorosilanes can be used as raw materials for preparing functional silanes or silane coupling agents. In the reaction with organometallic compounds, the chlorine atoms of triisopropylchlorosilane are replaced by corresponding organic groups to form organochlorosilanes or organofunctional silanes.
Triisopropyl chlorosilane is mainly used in the production of aminosilane and methacryloxysilane, and can also be used as a rubber processing additive to couple inorganic fillers in various halogenated rubbers, such as neoprene rubber, chlorobutyl rubber , chlorosulfonated polyethylene and other halogenated rubbers. The existence of triisopropylchlorosilane can greatly improve various physical and mechanical properties of composites. Triisopropylchlorosilane can also be used to prepare antifungal and deodorant finishes with special bactericidal, deodorant, antistatic and surface-active properties.

Triisopropylsilyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

3-BROMO-1-(TRIISOPROPYLSILYL)INDOLE
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Triisopropylsilyl chloride Suppliers

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View Lastest Price from Triisopropylsilyl chloride manufacturers

Hubei Changfu Chemical Co., Ltd.
Product
Triisopropylchlorosilane 13154-24-0
Price
US $0.00/kg
Min. Order
1kg
Purity
96%
Supply Ability
20t
Release date
2024-04-26
Hebei Weibang Biotechnology Co., Ltd
Product
Triisopropylsilyl chloride 13154-24-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Yanxi Chemical Co., Ltd.
Product
Triisopropylsilyl chloride 13154-24-0
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-06

13154-24-0, Triisopropylsilyl chlorideRelated Search:

Polyvinyl chloride Potassium chloride (+)-Diisopinocampheyl chloroborane Triethylsilane Iodotrimethylsilane CHLOROPHENYLSILANE 97 Cinnamyl chloride Chloromethyl silane Choline chloride Chloromethyl isopropyl carbonate Ammonium chloride Calcium chloride 2-Chloro-2-methylpropane Thionyl chloride Bromotrimethylsilane Triisopropylsilane DIMETHYLTHEXYLSILYL CHLORIDE Sodium chloride

  • TRIISOPROPYLCHLOROSILANE
  • TRIISOPROPYLSILYL CHLORIDE
  • TRIISOPROPYLCHLOROSILANE, REDISTILLED
  • tris-Isopropylchlorosilane
  • Triisopropylsilyl Clorid
  • Triisopropylchlorosilane (TIPSCl)
  • CHLOROTRIISOPROPYLSILANE, WACKER QUALITY
  • TRIISOPROPYLSILYL CHLORIDE, TECH., 90%
  • TRIISOPROPYLCHLOROSILANE 98%
  • SILANE IP3
  • TIPSCI
  • TIPSCL
  • CHLOROTRIISOPROPYLSILANE
  • Triisoprpylchlorosilane
  • TISC
  • TriisopropyL
  • chloro-tri(propan-2-yl)silane
  • Silane, chlorotris(1-methylethyl)-
  • Tris(isopropylsilyl) chloride
  • Chlorotriisopropylsilane, 97+%
  • Triisopropylsilyl chloride Chlorotriisopropylsilane
  • CHLOROTRIISOPROPYLSILANE FOR SYNTHESIS
  • Three isopropyl chlorosilanes
  • Chlorotriisopropylsilane, 97% 10GR
  • Chlorotriisopropylsilane, 97% 50GR
  • Chlorotriisopropylsilane, TIPSCl, Triisopropylchlorosilane, Triisopropylsilyl chloride
  • TIPSCl, Triisopropylchlorosilane, Triisopropylsilyl chloride
  • Silane IP3, TIPSCl, Triisopropylchlorosilane, Triisopropylsilyl chloride
  • Chlorotriisopropylsilane,95%
  • Triisopropylchlorosilane ,97%
  • Chlorotris(1-Methylethyl)silane
  • TRI ISOPROPYL CHLORO SILANE GENETICALLY MODIFIED
  • chlorotris(propan-2-yl)silane
  • Chloro[tris(isopropyl)]silane, Chloro[tris(prop-2-yl)]silane
  • Triisopropylsilyl chloride 97%
  • Three isopropyl chlorosilane
  • CHLOROTRIISOPROPYLSILANE, 98%CHLOROTRIISOPROPYLSILANE, 98%CHLOROTRIISOPROPYLSILANE, 98%
  • Triisopropylchlorsilane
  • Co-Formula CFS-240
  • Isopropylchlorosilane
  • Triisopropylchlorosilane (TISC)
  • DK511
  • DKFELEX0091
  • 13154-24-0
  • CH32CH23SiCl
  • C9H21ClSi
  • CH32CH3SiCl
  • Si (Classes of Silicon Compounds)
  • Silicon Compounds (for Synthesis)
  • Monochlorosilanes
  • Si-Cl Compounds
  • Protection and Derivatization
  • Protecting and Derivatizing Reagents
  • Synthetic Reagents
  • Silicon-Based
  • Miscellaneous
  • Aliphatics
  • Blocking Agents