TYRPHOSTIN AG 126
- Product Name
- TYRPHOSTIN AG 126
- CAS No.
- 118409-62-4
- Chemical Name
- TYRPHOSTIN AG 126
- Synonyms
- ag127;AG 126;A -126;TYRPHOSTIN A10;Tyrphostin 126;TYRPHOSTIN AG 126;RARECHEM AL BX 0673;AG 126; AG126; AG-126;TYRPHOSTIN AG 126 USP/EP/BP;AG 126 - CAS 118409-62-4 - Calbiochem
- CBNumber
- CB3407273
- Molecular Formula
- C10H5N3O3
- Formula Weight
- 215.16
- MOL File
- 118409-62-4.mol
TYRPHOSTIN AG 126 Property
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- Yellow solid
- color
- Light yellow to yellow
- Sensitive
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 658452
- Product name
- AG 126
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- J67211
- Product name
- Tyrphostin AG-126
- Packaging
- 5mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 13297
- Product name
- AG 126
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 13297
- Product name
- AG 126
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 13297
- Product name
- AG 126
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $154
- Updated
- 2024/03/01
TYRPHOSTIN AG 126 Chemical Properties,Usage,Production
Definition
ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.
Biological Activity
ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.
in vitro
previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].
in vivo
ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].
IC 50
inhibits the phosphorylation of erk1 and erk2 at 25-50 μm
References
[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).
TYRPHOSTIN AG 126 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN AG 126 Suppliers
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from TYRPHOSTIN AG 126 manufacturers
- Product
- TYRPHOSTIN AG 126 118409-62-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24