2-CYANO-4-METHYL-5-NITROPYRIDINE
- Product Name
- 2-CYANO-4-METHYL-5-NITROPYRIDINE
- CAS No.
- 267875-30-9
- Chemical Name
- 2-CYANO-4-METHYL-5-NITROPYRIDINE
- Synonyms
- 4-METHYL-5-NITROPICOLINONITRILE;2-CYANO-4-METHYL-5-NITROPYRIDINE;4-Methyl-5-nitro-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 4-methyl-5-nitro-;2-CYANO-4-METHYL-5-NITROPYRIDINEMETHYL ESTER;2-CYANO-4-METHYL-5-NITROPYRIDINE ISO 9001：2015 REACH;4-Methyl-5-Nitro-2-Pyridinecarbonitrile 2Cyano4methyl5nitropyridine
- CBNumber
- CB3426959
- Molecular Formula
- C7H5N3O2
- Formula Weight
- 163.13
- MOL File
- 267875-30-9.mol
2-CYANO-4-METHYL-5-NITROPYRIDINE Property
- Boiling point:
- 361.8±42.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.70±0.18(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C987948
- Product name
- 2-Cyano-4-methyl-5-nitropyridine
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 073849
- Product name
- 2-Cyano-4-methyl-5-nitropyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CHM0095387
- Product name
- 4-METHYL-5-NITROPYRIDINE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2674.98
- Updated
- 2021/12/16
- Product number
- W4999
- Product name
- 2-Cyano-4-methyl-5-nitropyridine
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- W4999
- Product name
- 2-Cyano-4-methyl-5-nitropyridine
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
2-CYANO-4-METHYL-5-NITROPYRIDINE Chemical Properties,Usage,Production
Synthesis
557-21-1
23056-47-5
267875-30-9
General procedure for the synthesis of 2-cyano-4-methyl-5-nitropyridine from zinc cyanide and 2-bromo-4-methyl-5-nitropyridine: In a round-bottomed flask 2-bromo-4-methyl-5-nitropyridine (104 g, 0.479 mol), zinc cyanide (79 g, 0.673 mol, 1.4 equiv.), and tetrakis(triphenylphosphine)palladium (0.023 mol, 5 mol%). Note: The use of a catalyst purchased from STREM significantly reduces the reaction time and increases the yield. DMF (900 mL) was degassed for 10 minutes and added to the solid mixture described above. The reaction mixture was heated in an oil bath until the internal temperature reached 80°C. When the internal temperature reached 80 °C, the color of the reaction solution changed from light yellow to light brown. Maintaining this temperature, the reaction mixture was stirred continuously for 3 hours and the reaction progress was monitored by TLC. After completion of the reaction, the solvent was removed under vacuum. The residue was dissolved in a mixture of dichloromethane and water and insoluble impurities were removed by filtration through diatomaceous earth. The organic layer was separated and the aqueous layer was extracted with dichloromethane. All organic extracts were combined, dried with anhydrous magnesium sulfate and concentrated. The concentrated residue was purified by column chromatography with the eluent gradually adjusted from 100% hexane to hexane/ethyl acetate (4:1). Finally, 65.8 g of the target product 2-cyano-4-methyl-5-nitropyridine was obtained by hexane recrystallization in 83% yield. The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.71 (s, 3H), 7.73 (s, 1H), 9.20 (s, 1H).LCMS analysis: APCI, [M-H]-=162 u/e, TIC purity: 95%; UV purity: 95%.
References
[1] Patent: WO2005/103003, 2005, A2. Location in patent: Page/Page column 61-62
[2] Patent: US2006/155128, 2006, A1. Location in patent: Page/Page column 66
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 5, p. 795 - 798
2-CYANO-4-METHYL-5-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CYANO-4-METHYL-5-NITROPYRIDINE manufacturers
- Product
- 2-CYANO-4-METHYL-5-NITROPYRIDINEMETHYL ESTER 267875-30-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-CYANO-4-METHYL-5-NITROPYRIDINE 267875-30-9
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02