ChemicalBook > CAS DataBase List > 2-CYANO-4-METHYL-5-NITROPYRIDINE

2-CYANO-4-METHYL-5-NITROPYRIDINE

Product Name: 2-CYANO-4-METHYL-5-NITROPYRIDINE
CAS No.: 267875-30-9
Chemical Name: 2-CYANO-4-METHYL-5-NITROPYRIDINE
Synonyms: 4-METHYL-5-NITROPICOLINONITRILE;2-CYANO-4-METHYL-5-NITROPYRIDINE;4-Methyl-5-nitro-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 4-methyl-5-nitro-;2-CYANO-4-METHYL-5-NITROPYRIDINEMETHYL ESTER;2-CYANO-4-METHYL-5-NITROPYRIDINE ISO 9001：2015 REACH;4-Methyl-5-Nitro-2-Pyridinecarbonitrile 2Cyano4methyl5nitropyridine
CBNumber: CB3426959
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 267875-30-9.mol

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2-CYANO-4-METHYL-5-NITROPYRIDINE Property

Boiling point:: 361.8±42.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3.70±0.18(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C987948
Product name: 2-Cyano-4-methyl-5-nitropyridine
Packaging: 100mg
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: W4999
Product name: 2-Cyano-4-methyl-5-nitropyridine
Packaging: 250mg
Price: $123
Updated: 2021/12/16

AK Scientific

Product number: W4999
Product name: 2-Cyano-4-methyl-5-nitropyridine
Packaging: 1g
Price: $227
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC75971
Product name: 2-Cyano-4-methyl-5-nitropyridine
Packaging: 250mg
Price: $227.5
Updated: 2021/12/16

Matrix Scientific

Product number: 073849
Product name: 2-Cyano-4-methyl-5-nitropyridine
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

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2-CYANO-4-METHYL-5-NITROPYRIDINE Chemical Properties,Usage,Production

Synthesis

557-21-1

23056-47-5

267875-30-9

General procedure for the synthesis of 2-cyano-4-methyl-5-nitropyridine from zinc cyanide and 2-bromo-4-methyl-5-nitropyridine: In a round-bottomed flask 2-bromo-4-methyl-5-nitropyridine (104 g, 0.479 mol), zinc cyanide (79 g, 0.673 mol, 1.4 equiv.), and tetrakis(triphenylphosphine)palladium (0.023 mol, 5 mol%). Note: The use of a catalyst purchased from STREM significantly reduces the reaction time and increases the yield. DMF (900 mL) was degassed for 10 minutes and added to the solid mixture described above. The reaction mixture was heated in an oil bath until the internal temperature reached 80°C. When the internal temperature reached 80 °C, the color of the reaction solution changed from light yellow to light brown. Maintaining this temperature, the reaction mixture was stirred continuously for 3 hours and the reaction progress was monitored by TLC. After completion of the reaction, the solvent was removed under vacuum. The residue was dissolved in a mixture of dichloromethane and water and insoluble impurities were removed by filtration through diatomaceous earth. The organic layer was separated and the aqueous layer was extracted with dichloromethane. All organic extracts were combined, dried with anhydrous magnesium sulfate and concentrated. The concentrated residue was purified by column chromatography with the eluent gradually adjusted from 100% hexane to hexane/ethyl acetate (4:1). Finally, 65.8 g of the target product 2-cyano-4-methyl-5-nitropyridine was obtained by hexane recrystallization in 83% yield. The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.71 (s, 3H), 7.73 (s, 1H), 9.20 (s, 1H).LCMS analysis: APCI, [M-H]-=162 u/e, TIC purity: 95%; UV purity: 95%.

References

[1] Patent: WO2005/103003, 2005, A2. Location in patent: Page/Page column 61-62
[2] Patent: US2006/155128, 2006, A1. Location in patent: Page/Page column 66
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 5, p. 795 - 798

2-CYANO-4-METHYL-5-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-CYANO-4-METHYL-5-NITROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-CYANO-4-METHYL-5-NITROPYRIDINEMETHYL ESTER 267875-30-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: 2-CYANO-4-METHYL-5-NITROPYRIDINE 267875-30-9
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

267875-30-9, 2-CYANO-4-METHYL-5-NITROPYRIDINERelated Search:

2-CYANO-4-NITROPYRIDINE 3,5-DIBROMO-PYRIDINE-2-CARBONITRILE 2-Cyano-3-methylpyridine-5-boronic acid,pinacol ester 2-Cyano-3,5-dimethylpyridine 2-Cyano-5-methoxypyridine 2-CYANO-3-METHOXYPYRIDINE 2-Cyano-5-methylpyridine 6-cyanopyridine-3-boronic acid 2-Cyano-5-hydroxypyridine 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 3-Amino-6-cyanopyridine 2-Cyano-5-nitropyridine 2-CYANO-4-METHYLPYRIDINE 3-Amino-4,6-dimethylpyridine 4,6-Dimethyl-3-nitropyridine 2-CYANO-4-METHYL-5-NITROPYRIDINE

2-CYANO-4-METHYL-5-NITROPYRIDINE

4-METHYL-5-NITROPICOLINONITRILE

4-Methyl-5-Nitro-2-Pyridinecarbonitrile 2Cyano4methyl5nitropyridine

4-Methyl-5-nitro-2-pyridinecarbonitrile

2-Pyridinecarbonitrile, 4-methyl-5-nitro-

2-CYANO-4-METHYL-5-NITROPYRIDINEMETHYL ESTER

2-CYANO-4-METHYL-5-NITROPYRIDINE ISO 9001：2015 REACH

267875-30-9

Heterocycle-Pyridine series