2,3,5,6-Tetrafluoropyridine

Synthesis Preparation Description

Product Name: 2,3,5,6-Tetrafluoropyridine
CAS No.: 2875-18-5
Chemical Name: 2,3,5,6-Tetrafluoropyridine
Synonyms: 2,3,5,6-TetrafL;2,3,5,6-TETRAFLUOROPYRIDINE;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;2,3,5,6-Tetrafluoropyridine 98%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
CBNumber: CB3444784
Molecular Formula: C5HF4N
Formula Weight: 151.06
MOL File: 2875-18-5.mol

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2,3,5,6-Tetrafluoropyridine Property

Boiling point:: 102 °C (lit.)
Density: 1.499 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4046(lit.)
Flash point:: 87 °F
storage temp.: Inert atmosphere,2-8°C
pka: -10.94±0.20(Predicted)
form: clear liquid
color: Colorless to Light yellow
Specific Gravity: 1.52
InChI: InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
InChIKey: HWIPMBCMGVXOKN-UHFFFAOYSA-N
SMILES: C1(F)=NC(F)=C(F)C=C1F
CAS DataBase Reference: 2875-18-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5)

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Safety

Hazard Codes: Xi,F,C
Risk Statements: 10-36/37/38
Safety Statements: 28-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable/Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 316679
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: 95%
Packaging: 1g
Price: $65.2
Updated: 2023/06/20

TCI Chemical

Product number: T1778
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $48
Updated: 2024/03/01

TCI Chemical

Product number: T1778
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $144
Updated: 2024/03/01

Alfa Aesar

Product number: B21905
Product name: 2,3,5,6-Tetrafluoropyridine, 97%
Packaging: 1g
Price: $41.1
Updated: 2021/12/16

Alfa Aesar

Product number: B21905
Product name: 2,3,5,6-Tetrafluoropyridine, 97%
Packaging: 5g
Price: $140
Updated: 2021/12/16

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2,3,5,6-Tetrafluoropyridine Chemical Properties,Usage,Production

Synthesis

Catalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.

Preparation

An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g, 118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm³) and heated at 200 ℃ for 48 h. The mixture was added to water and extracted into ether. The ether solution was shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by comparison of their GCMS and fluorine nmr spectra with authentic samples.

Description

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.

Chemical Properties

clear colorless liquid

2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,5,6-Tetrafluoropyridine Suppliers

Australia 1 Belgium 2 China 203 France 2 Germany 10 India 5 Italy 1 Japan 5 Jordan 1 Russia 2 Switzerland 2 The Netherlands 2 United Kingdom 19 United States 47 Global 302

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View Lastest Price from 2,3,5,6-Tetrafluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Fengda Chemical Co., Ltd

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $5.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-02

LY Global chemicals co.,ltd .

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-14

2875-18-5, 2,3,5,6-TetrafluoropyridineRelated Search:

2,3,5,6-TETRAFLUOROPYRIDINE

2,3,5,6-Tetrafluoropyridine 98%

2,3,5,6-Tetrafluoropyridine98%

2,3,5,6-Tetrafluoropyridine,99%

N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &

Pyridine,2,3,5,6-tetrafluoro-

2,3,5,6-TetrafL

2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH

2875-18-5

2875-18-8

C5HF4N

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