2,3,5,6-Tetrafluoropyridine

Synthesis Preparation Description

Product Name: 2,3,5,6-Tetrafluoropyridine
CAS No.: 2875-18-5
Chemical Name: 2,3,5,6-Tetrafluoropyridine
Synonyms: 2,3,5,6-TetrafL;2,3,5,6-TETRAFLUOROPYRIDINE;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;2,3,5,6-Tetrafluoropyridine 98%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
CBNumber: CB3444784
Molecular Formula: C5HF4N
Formula Weight: 151.06
MOL File: 2875-18-5.mol

More

Less

2,3,5,6-Tetrafluoropyridine Property

Boiling point:: 102 °C (lit.)
Density: 1.499 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4046(lit.)
Flash point:: 87 °F
storage temp.: Inert atmosphere,2-8°C
pka: -10.94±0.20(Predicted)
form: clear liquid
color: Colorless to Light yellow
Specific Gravity: 1.52
InChI: InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
InChIKey: HWIPMBCMGVXOKN-UHFFFAOYSA-N
SMILES: C1(F)=NC(F)=C(F)C=C1F
CAS DataBase Reference: 2875-18-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5)

More

Less

Safety

Hazard Codes: Xi,F,C
Risk Statements: 10-36/37/38
Safety Statements: 28-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable/Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 316679
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: 95%
Packaging: 1g
Price: $65.2
Updated: 2023/06/20

TCI Chemical

Product number: T1778
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $48
Updated: 2024/03/01

TCI Chemical

Product number: T1778
Product name: 2,3,5,6-Tetrafluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $144
Updated: 2024/03/01

Alfa Aesar

Product number: B21905
Product name: 2,3,5,6-Tetrafluoropyridine, 97%
Packaging: 1g
Price: $41.1
Updated: 2021/12/16

Alfa Aesar

Product number: B21905
Product name: 2,3,5,6-Tetrafluoropyridine, 97%
Packaging: 5g
Price: $140
Updated: 2021/12/16

More

Less

2,3,5,6-Tetrafluoropyridine Chemical Properties,Usage,Production

Synthesis

Catalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.

Preparation

An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g, 118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm³) and heated at 200 ℃ for 48 h. The mixture was added to water and extracted into ether. The ether solution was shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by comparison of their GCMS and fluorine nmr spectra with authentic samples.

Description

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.

Chemical Properties

clear colorless liquid

2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,3,5,6-Tetrafluoropyridine Suppliers

Australia 1 Belgium 2 China 204 France 2 Germany 10 India 5 Italy 1 Japan 5 Jordan 1 Russia 2 Switzerland 2 The Netherlands 2 United Kingdom 19 United States 47 Global 303

Tokyo Chemical Industry UK Ltd.

Tel: --
Fax: --
Email: sales@tci-uk.co.uk
Country: United Kingdom
ProdList: 1637
Advantage: 50

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Melrob Ltd (part of Nordmann)

Tel: --
Fax: --
Email: nquiries@melrob.com
Country: United Kingdom
ProdList: 3065
Advantage: 58

Biokemix

Tel: --
Fax: --
Email: info@biokemix.com
Country: United Kingdom
ProdList: 1066
Advantage: 58

Cenik Chemicals

Tel: --
Fax: --
Email: lo@cenikchemicals.com
Country: United Kingdom
ProdList: 1681
Advantage: 58

Fisher Scientific Uk Ltd.

Tel: --
Fax: --
Email: .international@thermofisher.com
Country: United Kingdom
ProdList: 2932
Advantage: 58

Molekula Limited

Tel: --
Fax: --
Email: o@molekula.com
Country: United Kingdom
ProdList: 6127
Advantage: 58

Biosynth Carbosynth

Tel: --
Fax: --
Email: ales@carbosynth.com
Country: United Kingdom
ProdList: 2598
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Apin Chemicals Limited (UK)

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

Goldfinch Laboratories

Tel: --
Fax: --
Email: goldfinchlabs@hotmail.com
Country: United Kingdom
ProdList: 731
Advantage: 30

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from 2,3,5,6-Tetrafluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Fengda Chemical Co., Ltd

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $5.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-02

LY Global chemicals co.,ltd .

Product: 2,3,5,6-Tetrafluoropyridine 2875-18-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-14

2875-18-5, 2,3,5,6-TetrafluoropyridineRelated Search:

2,3,5,6-TETRAFLUOROPYRIDINE

2,3,5,6-Tetrafluoropyridine 98%

2,3,5,6-Tetrafluoropyridine98%

2,3,5,6-Tetrafluoropyridine,99%

N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &

Pyridine,2,3,5,6-tetrafluoro-

2,3,5,6-TetrafL

2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH

2875-18-5

2875-18-8

C5HF4N

Fluoropyridines

C5

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halopyridines

Fluorine series

Pyridine

Heterocyclic Compounds

Fluoropyridines

Halopyridines

C5

Heterocyclic Building Blocks

Pyridines