Synthesis Preparation Description
ChemicalBook > CAS DataBase List > 2,3,5,6-Tetrafluoropyridine

2,3,5,6-Tetrafluoropyridine

Synthesis Preparation Description
Product Name
2,3,5,6-Tetrafluoropyridine
CAS No.
2875-18-5
Chemical Name
2,3,5,6-Tetrafluoropyridine
Synonyms
2,3,5,6-TetrafL;2,3,5,6-TETRAFLUOROPYRIDINE;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;2,3,5,6-Tetrafluoropyridine 98%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
CBNumber
CB3444784
Molecular Formula
C5HF4N
Formula Weight
151.06
MOL File
2875-18-5.mol
More
Less

2,3,5,6-Tetrafluoropyridine Property

Boiling point:
102 °C (lit.)
Density 
1.499 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4046(lit.)
Flash point:
87 °F
storage temp. 
Inert atmosphere,2-8°C
pka
-10.94±0.20(Predicted)
form 
clear liquid
color 
Colorless to Light yellow
Specific Gravity
1.52
InChI
InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
InChIKey
HWIPMBCMGVXOKN-UHFFFAOYSA-N
SMILES
C1(F)=NC(F)=C(F)C=C1F
CAS DataBase Reference
2875-18-5(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5)
More
Less

Safety

Hazard Codes 
Xi,F,C
Risk Statements 
10-36/37/38
Safety Statements 
28-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Flammable/Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
316679
Product name
2,3,5,6-Tetrafluoropyridine
Purity
95%
Packaging
1g
Price
$65.2
Updated
2023/06/20
TCI Chemical
Product number
T1778
Product name
2,3,5,6-Tetrafluoropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
T1778
Product name
2,3,5,6-Tetrafluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$144
Updated
2024/03/01
Alfa Aesar
Product number
B21905
Product name
2,3,5,6-Tetrafluoropyridine, 97%
Packaging
1g
Price
$41.1
Updated
2021/12/16
Alfa Aesar
Product number
B21905
Product name
2,3,5,6-Tetrafluoropyridine, 97%
Packaging
5g
Price
$140
Updated
2021/12/16
More
Less

2,3,5,6-Tetrafluoropyridine Chemical Properties,Usage,Production

Synthesis

Catalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.

Preparation

An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g,  118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for  48 h. The mixture was added to water and extracted into ether. The ether solution was  shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by  comparison of their GCMS and fluorine nmr spectra with authentic samples.  

Description

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.

Chemical Properties

clear colorless liquid

2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,3,5,6-Tetrafluoropyridine Suppliers

Australia 1 Belgium 2 China 201 France 2 Germany 10 India 5 Italy 1 Japan 5 Jordan 1 Russia 2 Switzerland 2 The Netherlands 2 United Kingdom 19 United States 47 Global 300
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
SpiroChem AG
Tel
Email
contact@spirochem.com
Country
United States
ProdList
38
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Sphinx Scientific Laboratory, LLC
Tel
--
Fax
--
Email
sales@sphinxscientificlab.com
Country
United States
ProdList
3343
Advantage
50
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
OX CHEM
Tel
--
Fax
--
Email
sales@ox-chem.com
Country
United States
ProdList
759
Advantage
50
True Pharmachem Inc.
Tel
--
Fax
--
Email
sales@truepharmachem.com
Country
United States
ProdList
226
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Louston International
Tel
--
Fax
--
Email
sales@louston.com
Country
United States
ProdList
525
Advantage
58
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
More
Less

View Lastest Price from 2,3,5,6-Tetrafluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Henan Fengda Chemical Co., Ltd
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $5.00-0.20/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-02
LY Global chemicals co.,ltd .
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%Min
Supply Ability
1000kg
Release date
2023-03-14

2875-18-5, 2,3,5,6-TetrafluoropyridineRelated Search:

Dimefluthrin 1,1,1,2-Tetrafluoroethane 4-Methyl-2,3,5,6-tetrafluoropyridine 99%+ 4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE,4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE 98% 4-CYANO-2,3,5,6-TETRAFLUOROPYRIDINE,2,3,5,6-Tetrafluoropyridine-4-carbonitrile Pentafluoropyridine 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,4,5-Tetrafluoropyridine 2,3,4,6-TETRAFLUOROPYRIDINE, 98+%,2,3,4,6-TETRAFLUOROPYRIDINE 2,3,5,6-TETRAFLUOROPYRIDINE-4-PROPIONIC ACID 3-Chloro-2,4,5,6-tetrafluoropyridine 2,3,5,6-TETRAFLUOROPYRIDINE-4-CARBOXYLIC ACID 4-HYDROXY-2,3,5,6-TETRAFLUOROPYRIDINE 4-HYDRAZINO-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE (2,3,5,6-TETRAFLUORO-4-PYRIDINYL)ACETIC ACID 4-CHLORO-2,3,5,6-TETRAFLUOROPYRIDINE

  • 2,3,5,6-TETRAFLUOROPYRIDINE
  • 2,3,5,6-Tetrafluoropyridine 98%
  • 2,3,5,6-Tetrafluoropyridine98%
  • 2,3,5,6-Tetrafluoropyridine,99%
  • N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &
  • Pyridine,2,3,5,6-tetrafluoro-
  • 2,3,5,6-TetrafL
  • 2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
  • 2875-18-5
  • 2875-18-8
  • C5HF4N
  • Fluoropyridines
  • C5
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halopyridines
  • Fluorine series
  • Pyridine
  • Heterocyclic Compounds
  • Fluoropyridines
  • Halopyridines
  • C5
  • Heterocyclic Building Blocks
  • Pyridines