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Angiotensin II human acetate

Product Name
Angiotensin II human acetate
CAS No.
68521-88-0
Chemical Name
Angiotensin II human acetate
Synonyms
HYPERTENSIN II;Ang II acetate;DRVYIHPF acetate;ANGIOTENSIN , HUMAN;Angiotensin Ⅱ, human;Angiotensin II xacetate;ANGIOTENSIN II ACETATE SALT;ANGIOTENSIN II ACETATE HUMAN;angiotensin ii human acetate;ANGIOTENSIN II, HUMAN, SYNTHETIC
CBNumber
CB3454530
Molecular Formula
C52H75N13O14
Formula Weight
1106.25
MOL File
68521-88-0.mol
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Angiotensin II human acetate Property

storage temp. 
−20°C
solubility 
H2O: 25 mg/mL, clear, colorless
form 
powder
color 
orange
Sequence
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
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Safety

WGK Germany 
3
F 
3-10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17150
Product name
Angiotensin II (human) (acetate)
Purity
≥90%
Packaging
1 mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
17150
Product name
Angiotensin II (human) (acetate)
Purity
≥90%
Packaging
5 mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
17150
Product name
Angiotensin II (human) (acetate)
Purity
≥90%
Packaging
10 mg
Price
$94
Updated
2024/03/01
Cayman Chemical
Product number
17150
Product name
Angiotensin II (human) (acetate)
Purity
≥90%
Packaging
25 mg
Price
$176
Updated
2024/03/01
Chem-Impex
Product number
32970
Product name
Angiotensin II acetate salt
Purity
≥ 99% (HPLC)
Packaging
100MG
Price
$280
Updated
2021/12/16
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Angiotensin II human acetate Chemical Properties,Usage,Production

Uses

Angiotensin II human acetate (Angiotensin II acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. It stimulates sympathetic nervous stimulation and increases aldosterone biosynthesis and renal actions. It also induces the growth of vascular smooth muscle cells. It increases collagen type I and III synthesis in fibroblasts, weakening the vascular wall, myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis.

in vitro

Most of the known actions of Angiotensin II (Ang II) human acetate are mediated by AT1 receptors; the AT2 receptor regulates blood pressure and renal function. Angiotensin II human acetate raises blood pressure (BP) through several actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis, and renal actions. Other Angiotensin II human acetate actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1). Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expression of LOX-1 and VEGF, capillary formation, intracellular reactive oxygen species generation, and phosphorylation of p38 as well as p44/42 mitogen-activated protein kinases were suppressed by anti-LOX-1 antibody, nicotinamide-adenine dinucleotide phosphate oxidase inhibitor apocynin and the Ang II type 1 receptor blocker Losartan, but not by the Ang II type 2 receptor blocker PD123319.

in vivo

Angiotensin II human acetate can be used to induce models of hypertension and cardiac hypertrophy[7][8][9].

1. Induction of hypertension[7]
Background
Angiotensin II human acetate can induce blood vessel constriction: After Ang II binds to its receptor (primarily the AT1 receptor), it activates a series of signaling pathways, such as the opening of calcium channels, leading to an increase in intracellular calcium concentration in vascular smooth muscle cells, causing them to contract, which in turn raises blood pressure;- Promoting inflammatory response: Ang II can also promote the production of inflammatory mediators, for example, by activating NADPH oxidase to produce excessive reactive oxygen species (ROS). These ROS can damage endothelial cells and promote the infiltration of inflammatory cells, resulting in thickening and hardening of the blood vessel walls, further exacerbating the development of hypertension;- Fibrosis and remodeling: Long-term exposure to high levels of Ang II leads to structural changes in the heart and blood vessels, including myocardial hypertrophy, ventricular remodeling, and fibrosis of the blood vessel walls, all of which are important pathological foundations for hypertension and its complications;- Dysregulation of water and sodium metabolism: As mentioned earlier, Ang II stimulates the adrenal cortex to secrete aldosterone, increasing sodium reabsorption in the kidneys, leading to water and sodium retention in the body, increasing blood volume, which raises blood pressure;- Neuroendocrine regulation: Ang II also plays a role in the regulation of the neuroendocrine system, such as influencing the activity of the sympathetic nervous system, enhancing its excitatory effects on the cardiovascular system, indirectly leading to increased blood pressure.
Specific Modeling Methods
Mice: C57/BL6J ? male and female ? 12-16 wk old ? 21-27 g
Administration: 800 ng/kg/min, 0.003 mL/min ? 7 days ? sc, osmotic pump implanted subcutaneously
Note
Effect of gender: Chronic ANG II-induced hypertension differs by gender in awake mice. Female mice may be protected from the ANG II-induced increase in blood pressure.
Modeling Indicators
Key Factor: Blood pressure ↑ on day 7, blood pressure in male was greater than in female.
Correlated Product(s): /
Opposite Product(s): /

2. Induction of Cardiac Hypertrophy[8][9]
Background
Angiotensin II human acetate activates receptors: Ang II exerts its biological effects primarily by binding to its specific receptor AT1R. Once AT1R is activated, it can trigger various downstream signaling pathways;- Intracellular signaling pathways: The activation of AT1R initiates several intracellular signaling cascades, such as the activation of phospholipase C (PLC), protein kinase C (PKC), and the phosphorylation of members of the mitogen-activated protein kinase (MAPKs) family. These signaling pathways work together to promote the proliferation of cardiac myocytes and protein synthesis, leading to cardiac hypertrophy;- Inflammatory response: Ang II can promote the production of inflammatory factors like tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which can further exacerbate myocardial injury and the fibrosis process;- Oxidative stress: Ang II can stimulate the generation of reactive oxygen species (ROS), and excessive ROS can not only directly damage cardiac myocytes but also activate transcription factors like NF-κB, enhancing the inflammatory response and cell apoptosis;- Extracellular matrix remodeling: Prolonged stimulation by Ang II leads to changes in extracellular matrix components, such as excessive deposition of collagen, which increases myocardial stiffness and disrupts normal heart function.
Specific Modeling Methods
Mice: C57/BL6J ? male ? 8 wk old &bull
Administration: 2 μg/kg/min ? 4 weeks ? sc, osmotic pump implanted subcutaneously
Note
Modeling Indicators
Indicator changes: Blood pressure in WT mice increased significantly.
Appearance monitoring: cardiac hypertrophy and fibrosis.
Correlated Product(s): /
Opposite Product(s): Eplerenone (HY-B0251)

IC 50

AT2 Receptor; AT1 Receptor

Angiotensin II human acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Angiotensin II human acetate Suppliers

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View Lastest Price from Angiotensin II human acetate manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT 68521-88-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2025-10-07
Shandong Hanjiang Chemical Co., Ltd
Product
Angiotensin II human acetate 68521-88-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2025-10-02
RongNa Biotechnology Co.,Ltd
Product
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT 68521-88-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26

68521-88-0, Angiotensin II human acetateRelated Search:

ASP-ARG-VAL-TYR-ILE-HIS-PRO Angiotensin acetate ANGIOTENSIN II, HUMAN ANGIOTENSIN III, HUMAN ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE ANGIOTENSIN I/II (3-7) BZ-GLY-GLY-GLY-OH ANGIOTENSIN I/II (5-8) ANGIOTENSIN I HUMAN ACETATE HYDRATE ANGIOTENSIN 1/2 + A (2 - 8) ANGIOTENSIN III, HUMAN Inositol ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT (2S)-1-[(2S)-2-Amino-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxamide Angiotensin H-PRO-PHE-OH ANGIOTENSIN II, HUMAN, TAMRA-LABELED H-VAL-GLY-VAL-ALA-PRO-GLY-OH

  • ANGIOTENSIN II ACETATE SALT
  • ANGIOTENSIN II HUMAN ACETATE SALT
  • ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT
  • HYPERTENSIN II
  • ANGIOTENSIN II ACETATE HUMAN
  • ANGIOTENSIN II-FLUORESCEIN SYNTHETIC >81 %
  • ANGIOTENSIN II, MASS SPEC STANDARD
  • ANGIOTENSIN II, HUMAN, SYNTHETIC
  • angiotensin ii human acetate
  • ANGIOTENSIN , HUMAN
  • Angiotensin Ⅱ, human
  • angiotensin II, 5-L-isoleucine-, acetate (salt)
  • 5-L-Isoleucineangiotensin II acetate
  • Human angiotensin II acetate salt
  • Angiotensin II huMan acetate hydrate
  • ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT USP/EP/BP
  • Angiotensin II xacetate
  • Ang II acetate
  • DRVYIHPF acetate
  • Angiotensin Receptor,Inhibitor,Angiotensin II human,inhibit,Angiotensin II,Ang II,DRVYIHPF,Apoptosis,Angiotensin II human acetate
  • (2S,5S,8S,11S,14S,17S)-2-((1H-Imidazol-5-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid xacetic acid
  • 68521-88-0
  • C52H75N13O14
  • C50H71N13O12xC2H4O2
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