ChemicalBook > CAS DataBase List > Amoxicillin sodium

Amoxicillin sodium

Product Name: Amoxicillin sodium
CAS No.: 34642-77-8
Chemical Name: Amoxicillin sodium
Synonyms: AMOXYCILLIN SODIUM;(3as,6ar)-1,3-dibenzyltetrahydro-1h-thieno[3,4-d]imidazole-2,4-dione;amoxilinna;amoxiclllln sodium;AMOXICILLIN SODIUM;SODIUM AMOXICILLIN;Amoxicillin Sodium Salt;Amoxycillin sodium salt;Amoxycilline Sodium Sterile;AmoxycillinSodiumSterileBp98
CBNumber: CB3462115
Molecular Formula: C16H20N3NaO5S
Formula Weight: 389.4
MOL File: 34642-77-8.mol

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Amoxicillin sodium Property

Melting point:: 130℃
Boiling point:: 743℃
RTECS: XH8300000
Flash point:: >110°(230°F)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Very soluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in acetone.
form: Liquid
color: White to light yellow
Water Solubility: Soluble in water.
InChIKey: QLKRYDZJRDWEHH-AGYZSTNLNA-N
SMILES: C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|
CAS DataBase Reference: 34642-77-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC

Product number: A634548
Product name: Amoxicillinsodium(Amox)
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-2581
Product name: Amoxicillin(sodium)
Purity: 99.47%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA37803
Product name: Amoxicillin sodium
Packaging: 1g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J51043
Product name: Amoxicillinsodium
Packaging: 1g
Price: $11
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA37803
Product name: Amoxicillin sodium
Packaging: 10g
Price: $250
Updated: 2021/12/16

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Amoxicillin sodium Chemical Properties,Usage,Production

Chemical Properties

White or almost white, very hygroscopic, powder.

Uses

Antibiotic[Note—Amoxicillin sodium will be used in combination with clavulanate potassium and marketed as ‘‘Augmentin for intravenous administration’’].

Definition

ChEBI: Amoxicillin sodium is an organic sodium salt that is the monosodium salt of amoxicillin. It contains an amoxicillin(1-).

Contact allergens

Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.

Synthesis

26787-78-0

34642-77-8

Synthesis of (2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid as sodium salt. 7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid in the following general steps: Example 1: Preparation of sterile sodium amoxicillin using methyl acetate as solvent. The specific operations were as follows: 1. amoxicillin trihydrate (50 g) was dissolved in a solvent mixture of methyl acetate (92 mL), triethylamine (34 g) and methanol (52 mL). 2. The reaction mixture was stirred continuously at a temperature of 0-5°C until a clarified solution was formed, followed by filtration through a sterile filtration system. 3. sodium 2-ethylhexanoate (34 g) was dissolved in a solvent mixture of methyl acetate (92 mL) and methanol (52 mL) and filtered through a sterile filtration system. 4. The sodium 2-ethylhexanoate solution prepared in Step 3 was slowly added to the amoxicillin trihydrate solution from Step 2, maintaining the reaction temperature between 0-5°C. 5. After 80 minutes of reaction, methyl acetate (10 mL) was added to promote precipitation of the product. 6. The precipitate was collected by filtration, washed with methyl acetate (240 mL) and dried at a temperature lower than 50 °C, resulting in sterile sodium amoxicillin. Product yield was >90%.

References

[1] Patent: WO2011/158133, 2011, A1. Location in patent: Page/Page column 7
[2] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 9
[3] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 11
[4] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 11

Amoxicillin sodium Preparation Products And Raw materials

Raw materials

Amoxicillin trihydrate

Preparation Products

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View Lastest Price from Amoxicillin sodium manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Amoxicillin sodium 34642-77-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Amoxicillin sodium 34642-77-8
Price: US $0.00/BOU/Tin
Min. Order: 5KG
Purity: 98%~102%
Supply Ability: 5ton/month
Release date: 2021-06-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: Amoxicillin Sodium 34642-77-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

34642-77-8, Amoxicillin sodiumRelated Search:

Chlorodimethylphenylsilane Dimethicone Acetylacetone Amoxicillin Sodium chloride N,N-Dimethylformamide Dimethyl sulfone Acetyl coenzyme A sodium salt Sodium acetate Dimethyl sulfoxide Sodium hydroxide Sodium benzoate Diclofenac sodium N,N-Dimethyl-1,4-phenylenediamine Sodium bicarbonate N,N-Dimethylacetamide Poly(dimethylsiloxane) Sodium citrate

amoxilinna

sodium 6-[[2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Amoxycillin sodium Crystalline

AmoxycillinSodiumSterileBp98

amoxiclllln sodium

(2S,5R,6R)-6-[[(R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt

(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt (1:1)

Amoxycilline Sodium Sterile

(2S,5β)-6α-[[(R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid sodium salt

Amoxycillin sodium salt

AMoxicillin SodiuM+Clavulanate PotassiuM(4:1)

(3as,6ar)-1,3-dibenzyltetrahydro-1h-thieno[3,4-d]imidazole-2,4-dione

AMOXICILLIN SODIUM

AMOXYCILLIN SODIUM

SODIUM AMOXICILLIN

sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Na-6-[D-a-Amino-p-hydroxyphenylacetamido]penicillanic acid

Amoxicillin Sodium Salt

Amoxicillin sodium USP/EP/BP

Sodium (2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Amoxicillin Sodium (Amoxycillin)

Amoxicillin Sodium IP (Sterile)Q: What is Amoxicillin Sodium IP (Sterile) Q: What is the CAS Number of Amoxicillin Sodium IP (Sterile) Q: What is the storage condition of Amoxicillin Sodium IP (Sterile) Q: What are the applications of Amoxicillin Sodium IP (Sterile)

TIANFUCHEM--34642-77-8--Amoxicillin sodium

Amoxicillin Sodium, 10 mM in DMSO

AMOXICILLIN SODIUM (NON-STERILE)

Amoxicillin Sodium - Aseptic Powder

Amoxicillin (Amoxycillin) sodium

sodium (2S,5R,6R)-6-(2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Amoxicillin Dimer Sodium (>90%)

Sodium (2S,5R,6R)-6-(2-amino-2-(4-hydroxy-phenyl)-acetcarboxcarboxcarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

34642-77-8

C16H18N3O5SNa

C16H18N3NaO5S

Inhibitors

Pharma

34642-77-8