Amoxicillin sodium
- Product Name
- Amoxicillin sodium
- CAS No.
- 34642-77-8
- Chemical Name
- Amoxicillin sodium
- Synonyms
- AMOXYCILLIN SODIUM;(3as,6ar)-1,3-dibenzyltetrahydro-1h-thieno[3,4-d]imidazole-2,4-dione;amoxilinna;amoxiclllln sodium;AMOXICILLIN SODIUM;SODIUM AMOXICILLIN;Amoxicillin Sodium Salt;Amoxycillin sodium salt;Amoxycilline Sodium Sterile;AmoxycillinSodiumSterileBp98
- CBNumber
- CB3462115
- Molecular Formula
- C16H20N3NaO5S
- Formula Weight
- 389.4
- MOL File
- 34642-77-8.mol
Amoxicillin sodium Property
- Melting point:
- 130℃
- Boiling point:
- 743℃
- RTECS
- XH8300000
- Flash point:
- >110°(230°F)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Very soluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in acetone.
- form
- Liquid
- color
- White to light yellow
- Water Solubility
- Soluble in water.
- InChIKey
- QLKRYDZJRDWEHH-AGYZSTNLNA-N
- SMILES
- C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|
- CAS DataBase Reference
- 34642-77-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- A634548
- Product name
- Amoxicillinsodium(Amox)
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-2581
- Product name
- Amoxicillin(sodium)
- Purity
- 99.47%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA37803
- Product name
- Amoxicillin sodium
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J51043
- Product name
- Amoxicillinsodium
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
- Product number
- FA37803
- Product name
- Amoxicillin sodium
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
Amoxicillin sodium Chemical Properties,Usage,Production
Chemical Properties
White or almost white, very hygroscopic, powder.
Uses
Antibiotic[Note—Amoxicillin sodium will be used in combination with clavulanate potassium and marketed as ‘‘Augmentin for intravenous administration’’].
Definition
ChEBI: Amoxicillin sodium is an organic sodium salt that is the monosodium salt of amoxicillin. It contains an amoxicillin(1-).
Contact allergens
Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.
Synthesis
26787-78-0
34642-77-8
Synthesis of (2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid as sodium salt. 7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid in the following general steps: Example 1: Preparation of sterile sodium amoxicillin using methyl acetate as solvent. The specific operations were as follows: 1. amoxicillin trihydrate (50 g) was dissolved in a solvent mixture of methyl acetate (92 mL), triethylamine (34 g) and methanol (52 mL). 2. The reaction mixture was stirred continuously at a temperature of 0-5°C until a clarified solution was formed, followed by filtration through a sterile filtration system. 3. sodium 2-ethylhexanoate (34 g) was dissolved in a solvent mixture of methyl acetate (92 mL) and methanol (52 mL) and filtered through a sterile filtration system. 4. The sodium 2-ethylhexanoate solution prepared in Step 3 was slowly added to the amoxicillin trihydrate solution from Step 2, maintaining the reaction temperature between 0-5°C. 5. After 80 minutes of reaction, methyl acetate (10 mL) was added to promote precipitation of the product. 6. The precipitate was collected by filtration, washed with methyl acetate (240 mL) and dried at a temperature lower than 50 °C, resulting in sterile sodium amoxicillin. Product yield was >90%.
References
[1] Patent: WO2011/158133, 2011, A1. Location in patent: Page/Page column 7
[2] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 9
[3] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 11
[4] Patent: WO2006/72577, 2006, A1. Location in patent: Page/Page column 11
Amoxicillin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Amoxicillin sodium Suppliers
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View Lastest Price from Amoxicillin sodium manufacturers
- Product
- Amoxicillin sodium 34642-77-8
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30
- Product
- Amoxicillin sodium 34642-77-8
- Price
- US $0.00/BOU/Tin
- Min. Order
- 5KG
- Purity
- 98%~102%
- Supply Ability
- 5ton/month
- Release date
- 2021-06-07
- Product
- Amoxicillin Sodium 34642-77-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21