ChemicalBook > CAS DataBase List > 17-DMAG

17-DMAG

Product Name
17-DMAG
CAS No.
467214-21-7
Chemical Name
17-DMAG
Synonyms
KOS 1022;BMS 826476;Risatriptan;BMS 826476 HCl;AlvespiMycin HCl;MK 462 free base;17-DMAG USP/EP/BP;KOS-1022 hydrochloride;Spiramycin hydrochloride;17-DMAG HCl (AlvespiMycin)
CBNumber
CB3469563
Molecular Formula
C32H49ClN4O8
Formula Weight
653.21
MOL File
467214-21-7.mol
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17-DMAG Property

storage temp. 
Store at -20
solubility 
≥26.2 mg/mL in DMSO; insoluble in EtOH; ≥3.04 mg/mL in H2O
form 
Purple solid
color 
Purple to purplish red
Water Solubility 
water: 10mg/mL
DMSO: 5mg/mL
InChIKey
KUFRQPKVAWMTJO-LMZWQJSESA-N
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Safety

HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
100069
Product name
17-DMAG - CAS 467214-21-7 - Calbiochem
Purity
A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.
Packaging
500μG
Price
$332
Updated
2024/03/01
TRC
Product number
D470930
Product name
17-N-(2-Dimethylaminoethylamino)-17-demethoxyGeldanamycinHydrochloride
Packaging
2.5mg
Price
$140
Updated
2021/12/16
ApexBio Technology
Product number
A2213
Product name
17-DMAG(Alvespimycin)HCl
Packaging
10mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0162
Product name
Alvespimycinhydrochloride
Purity
98.72%
Packaging
10mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
A2213
Product name
17-DMAG(Alvespimycin)HCl
Packaging
10mM(in 1mL DMSO)
Price
$70
Updated
2021/12/16
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17-DMAG Chemical Properties,Usage,Production

Uses

Treatment of solid and hematological tumors.

Uses

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Biological Activity

17-dmag is an inhibitor of hsp90 with ic50 value of 62±29nm [1].17-dmag can bind to the atp-binding motif of hsp90 and inhibit the protein chaperoning activity of hsp90. it will cause misfolding and subsequent degradation of hsp90’s client proteins, such as egfr, akt, mutant p53, and ikk. since there is more specific conformation hsp90 required for 17-dmag binding in tumor cells and many client proteins of hsp90 contribute to tumor cell growth, 17-dmag is usually more toxic to tumor cells than to normal cells [2].17-dmag is reported as an antitumor agent with more broadly exploitable activity and more pharmaceutically tractable characteristics in the in vitro and initial in vivo assay. 17-dmag can effect cell growth when treating the nci 60 cell lines with it, the mean gi50 is 0.053mm. the in vivo activity of 17-dmag is tested in four melanoma models using the freiburg human tumor xenograft panel and two lung xenografts. it shows that 17-dmag has high activity in the two lung xenografts and two of the four melanoma models, but not in another two, mexf 462 and mexf 514 [3].

Enzyme inhibitor

This potent Hsp90 inhibitor (FWHCl-Salt = 653.21 g/mol; CAS 467214-21-7), also named 17-DMAG and 17-demethoxy-17-[[2-(dimethylamino) ethyl]amino]geldanamycin, targets Heat Shock Protein-90 (IC50 = 62 nM in a cell-free assay). (See also Ansamycin; Deguelin; Derrubone; Ganetespib; Geldanamycin; Herbimycin; Macbecin; Radicicol; Tanespimycin; and the nonansamycin Hsp90 inhibitor KW-2478)

storage

Desiccate at -20°C

References

[1] jie ge, emmanuel normant, james r. porter, janid a. ali, marlene s. dembski, yun gao, asimina t. georges, louis grenier, roger h. pak, jon patterson, jens r. sydor, thomas t. tibbitts, jeffrey k. tong, julian adams, and vito j. palombella. design, synthesis and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of hsp90. j. med. chem. 2006, 49, 4606-4615.
[2] xiaoping sun, jillian a. bristol, satoko iwahori, stacy r. hagemeier, qiao meng, elizabeth a. barlow, joyce d. fingeroth, vera l. tarakanova, robert f. kalejta, shannon c. kenney. hsp90 inhibitor 17-dmag decreases expression of conserved herpesvirus protein kinases and reduces virus production inepstein-barr virus-infected cells. journal of virology. 2013, 87 (18): 10126–10138.
[3] melinda hollingshead, michael alley, angelika m. burger, suzanne borgel,christine pacula-cox, heinz-herbert fiebig, edward a. sausville. in vivo antitumor efficacy of 17-dmag (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative. cancer chemother pharmacol. 2005, 56: 115–125.

17-DMAG Preparation Products And Raw materials

Raw materials

Preparation Products

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17-DMAG Suppliers

AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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BOC Sciences
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inquiry@bocsci.com
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United States
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InvivoChem
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sales@invivochem.cn
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Aladdin Scientific
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TargetMol Chemicals Inc.
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View Lastest Price from 17-DMAG manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
17-DMAG 467214-21-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alvespimycin hydrochloride 467214-21-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alvespimycin hydrochloride 467214-21-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

467214-21-7, 17-DMAGRelated Search:


  • 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN
  • 17-DMAG - CAS 467214-21-7 - Calbiochem
  • Alvespimycin Hydrochloride (17-DMAG Hydrochloride
  • Alvespimycin (17-DMAG) hydrochloride
  • KOS-1022 hydrochloride
  • 17-DIMETHYLAMINOGELDANAMYCIN
  • Alvespimycin hydrochloride
  • BMS 826476
  • KOS 1022
  • AlvespiMycin hydrochloride(17-DMAG,BMS 826476
  • 17-DMAG HCl (AlvespiMycin)
  • 17-DMAG (AlvespiMycin) HCl
  • AlvespiMycin HCl
  • Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, monohydrochloride
  • NSC 707545,BMS 826476 HCl,KOS 1022
  • Alvespimycin (17-DMAG) HCl
  • 17DMAG; NSC 707545; KOS-1022; BMS 826476 HCL;KOS 1022
  • BMS 826476 HCl
  • Geldanamycin 17-N-(2-Dimethylaminoethylamino)
  • 17-DMAG hydrochloride (Alvespimycin)
  • 17-DMAG USP/EP/BP
  • MK 462 free base
  • Risatriptan
  • 17-DMAG Hydrochloride Salt Alvespimycin
  • Spiramycin hydrochloride
  • 17-DMAG hydrochloride (Avespimycin)
  • BMS 826476|||NSC 707545|||KOS-1022|||17-DMAG hydrochloride|||Alvespimycin (17-DMAG) HCl
  • Alvespimycin hydrochloride, 10 mM in DMSO
  • 467214-21-7
  • C32H48N4O8
  • Inhibitors
  • Anti-cancer&immunity