2-Fluoro-4-cyanobenzyl bromide

Product Name: 2-Fluoro-4-cyanobenzyl bromide
CAS No.: 105942-09-4
Chemical Name: 2-Fluoro-4-cyanobenzyl bromide
Synonyms: 4-Cyano-2-fluorbenzylbromid;4-(BroMoMethyl)-3-fluoroben;4-CYANO-2-FLUOROBENZYL BROMIDE;2-FLUORO-4-CYANO-BENZYLBROMIDE;4-Cyano-2-fluorobenzylbromide97%;4-(BROMOMETHYL)-3-FLUOROBENZONITRILE;BENZONITRILE, 4-(BROMOMETHYL)-3-FLUORO-;4-(Bromomethyl)-3-fluorobenzonitrile 97%;4-(Bromomethyl)-3-fluorobenzonitrile >4-BroMoMethyl-3-fluorobenzonitrile[4-cyano-2-fluorobenzyl broMide]
CBNumber: CB3471393
Molecular Formula: C8H5BrFN
Formula Weight: 214.03
MOL File: 105942-09-4.mol

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2-Fluoro-4-cyanobenzyl bromide Property

Melting point:: 77 °C
Boiling point:: 276.4±30.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Solid
color: Off-white
Sensitive: Lachrymatory
InChI: InChI=1S/C8H5BrFN/c9-4-7-2-1-6(5-11)3-8(7)10/h1-3H,4H2
InChIKey: ZESZAIOGACKOMB-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(CBr)C(F)=C1
CAS DataBase Reference: 105942-09-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
RIDADR: 3439
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3204
Product name: 4-(Bromomethyl)-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B3204
Product name: 4-(Bromomethyl)-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $93
Updated: 2025/07/31

TCI Chemical

Product number: B3204
Product name: 4-(Bromomethyl)-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $280
Updated: 2025/07/31

TRC

Product number: C987958
Product name: 4-Cyano-2-fluorobenzylbromide
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK584614
Product name: 4-Cyano-2-fluorobenzylbromide
Purity: 98%
Packaging: 1g
Price: $76
Updated: 2021/12/16

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2-Fluoro-4-cyanobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

White to yellow fine crystalline powder

Uses

2-Fluoro-4-cyanobenzyl bromide can be used in organic synthesis.

Synthesis

170572-49-3

105942-09-4

General procedure for the synthesis of 4-cyano-2-fluorobenzyl bromide from 3-fluoro-4-methylbenzonitrile: 3-fluoro-4-methylbenzonitrile (40 g, 296 mmol), N-bromosuccinimide (NBS, 63.2 g, 356 mmol), and benzoyl peroxide (3.6 g, 14.8 mmol) were dissolved in carbon tetrachloride (490 mL), and the reaction was performed at reflux for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated and purified by fast column chromatography (eluent: 0-5% ethyl acetate/hexane) to afford the target product 4-(bromomethyl)-3-fluorobenzonitrile (35.4 g, 56% yield).

References

[1] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 12, p. 1647 - 1650
[2] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 12, p. 1203 - 1207
[4] Patent: WO2016/109361, 2016, A2. Location in patent: Paragraph 00144
[5] Patent: US2010/240719, 2010, A1. Location in patent: Page/Page column 11

2-Fluoro-4-cyanobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-cyanobenzyl bromide Suppliers

Americas 1 China 196 Europe 1 France 1 Germany 3 India 5 Italy 1 Japan 1 Ukraine 2 United Kingdom 14 United States 23 Global 248

Changzhou Bohan Chemical Co., Ltd

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View Lastest Price from 2-Fluoro-4-cyanobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-12

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-18

Career Henan Chemical Co

Product: 2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 100kg
Release date: 2019-07-04

105942-09-4, 2-Fluoro-4-cyanobenzyl bromideRelated Search:

alpha-Chloro-o-fluorotoluene Ethidium bromide BENDROFLUMETHIAZIDE Vecuronium bromide Ethyl bromodifluoroacetate Allyl bromide Rocuronium bromide Sodium bromate Dimidium bromide Bromofluoromethane Benzyl bromide Fluorine 3-CYANO-4-FLUOROBENZYL BROMIDE 4-Cyanobenzyl bromide 2-FLUORO-4-METHYLBENZYL BROMIDE Methyl bromide 2-Fluorobenzyl bromide 4-Nitrobenzyl bromide

2-FLUORO-4-CYANO-BENZYLBROMIDE

BENZONITRILE, 4-(BROMOMETHYL)-3-FLUORO-

4-Cyano-2-fluorobenzylbromide97%

4-Cyano-2-fluorbenzylbromid

4-(Bromomethyl)-3-fluorobenzonitrile 97%

4-Cyano-2-fluorobenzyl bromide, alpha-Bromo-3-fluoro-p-tolunitrile

4-CYANO-2-FLUOROBENZYL BROMIDE

4-(BROMOMETHYL)-3-FLUOROBENZONITRILE

4-(BroMoMethyl)-3-fluoroben

4-BroMoMethyl-3-fluorobenzonitrile[4-cyano-2-fluorobenzyl broMide]

4-(Bromomethyl)-3-fluorobenzonitrile &gt

105942-09-4

Aromatic Halides (substituted)

Methyl Halides

Phenyls & Phenyl-Het

Methyl Halides

Phenyls & Phenyl-Het

Fluorine series