ChemicalBook > CAS DataBase List > 1-(5-Chloro-2-hydroxyphenyl)ethanone

1-(5-Chloro-2-hydroxyphenyl)ethanone

Product Name
1-(5-Chloro-2-hydroxyphenyl)ethanone
CAS No.
1450-74-4
Chemical Name
1-(5-Chloro-2-hydroxyphenyl)ethanone
Synonyms
1-(5-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-CHLORO-2-HYDROXYACETOPHENONE;1-(3-chlorophenyl)-2-hydroxyethan-1-one;AKOS BB-6937;ASISCHEM D38764;SALOR-INT L497495-1EA;2-Acetyl-4-chlorophenol;oro-2'-hydroxyacetophenone;2'-hydroxy-5'-chlorophenone;2-HYDROXY-5-CHLORO ACETOPHENONE
CBNumber
CB3482191
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
1450-74-4.mol
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1-(5-Chloro-2-hydroxyphenyl)ethanone Property

Melting point:
54-56 °C(lit.)
Boiling point:
126-128 °C28 mm Hg(lit.)
Density 
1.2315 (rough estimate)
refractive index 
1.5590 (estimate)
Flash point:
107-109°C/12mm
storage temp. 
Sealed in dry,Room Temperature
form 
Solid
pka
9.72±0.18(Predicted)
BRN 
1365589
InChI
InChI=1S/C8H7ClO2/c1-5(10)7-4-6(9)2-3-8(7)11/h2-4,11H,1H3
InChIKey
XTGCUDZCCIRWHL-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC(Cl)=CC=C1O)C
CAS DataBase Reference
1450-74-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
383384
Product name
5′-Chloro-2′-hydroxyacetophenone
Purity
99%
Packaging
5g
Price
$26.6
Updated
2025/07/31
Sigma-Aldrich
Product number
383384
Product name
5′-Chloro-2′-hydroxyacetophenone
Purity
99%
Packaging
25g
Price
$45.79
Updated
2025/07/31
TCI Chemical
Product number
C2119
Product name
1-(5-Chloro-2-hydroxyphenyl)ethan-1-one
Purity
min. 98.0 %
Packaging
5G
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
C2119
Product name
1-(5-Chloro-2-hydroxyphenyl)ethan-1-one
Purity
min. 98.0 %
Packaging
25G
Price
$150
Updated
2025/07/31
TRC
Product number
C381338
Product name
1-(5-Chloro-2-hydroxyphenyl)ethanone
Packaging
500mg
Price
$45
Updated
2021/12/16
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1-(5-Chloro-2-hydroxyphenyl)ethanone Chemical Properties,Usage,Production

Chemical Properties

slightly yellow crystalline powder or chunks

Uses

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:

  • 6-chloro-2-methyl-4H-chrome-4-one
  • 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
  • 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
  • 2-styrenyl allyl ether

Preparation

Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).

General Description

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.

Synthesis

876-27-7

1450-74-4

General procedure for the synthesis of 5'-chloro-2'-hydroxyacetophenone from acetic acid-4-chlorophenyl ester: Acetic acid-4-chlorophenyl ester (10 g, 0.091 mol) was placed in a 500 ml round-bottomed flask with aluminum chloride (14.56 g, 0.11 mol). The mixture was heated in an oil bath at 140-150°C for 5-6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using ethyl acetate:hexane as the unfolding agent. Upon completion of the reaction, the reaction mixture was quenched with crushed ice and the solid product was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with saturated brine solution (2 x 15 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by recrystallization from aqueous solution. The yield is 90% and the melting point is 54-56°C.

References

[1] Chinese Chemical Letters, 2016, vol. 27, # 7, p. 1058 - 1063
[2] Synthesis, 1985, # 9, p. 901 - 902
[3] Tetrahedron, 2011, vol. 67, # 3, p. 641 - 649
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 2, p. 184 - 185
[5] Indian Journal of Heterocyclic Chemistry, 2011, vol. 21, # 2, p. 151 - 156

1-(5-Chloro-2-hydroxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Chloro-2-hydroxyphenyl)ethanone Suppliers

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View Lastest Price from 1-(5-Chloro-2-hydroxyphenyl)ethanone manufacturers

Honest Joy Holdings Limited
Product
5'-Chloro-2'-hydroxyacetophenone 1450-74-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
1-(5-Chloro-2-hydroxyphenyl)ethanone 1450-74-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

1450-74-4, 1-(5-Chloro-2-hydroxyphenyl)ethanoneRelated Search:

6-CHLOROCHROMAN-4-ONE 6,8-DICHLORO-3-FORMYLCHROMONE 5-Chloro-2-hydroxybenzophenone (+)-Griseofulvin 1-(5-Chloro-2-hydroxyphenyl)ethanone 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 2-AMINO-6-CHLORO-3-FORMYLCHROMONE MECLOCYCLINE SULFOSALICYLATE SALT Demeclocycline hydrochloride 5-CHLORO-BENZOFURAN-3-ONE Chlortetracycline hydrochloride 5-CHLORO-2-HYDROXY-4-METHYLBENZOPHENONE 1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone,1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone, 5-Chloro-3-bromo-2-hydroxyacetophenone 2-Chloro-3',4'-dihydroxyacetophenone 2-BROMO-1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE 1-(2-Chloro-6-hydroxyphenyl)ethanone 2'-Chloro-4'-hydroxyacetophenone 1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE

  • JRH-01003, 1-(5-Chloro-2-hydroxyphenyl)ethanone, 97%
  • SALOR-INT L497495-1EA
  • 2-Acetyl-4-chlorophenol
  • 5'-Chloro-2'-Hydroxy Acetophenone 2'-Hydorxy-5'-Chloro Acetophenone
  • 2'-Hydorxy-5'-ChloroAcetophenone
  • Acetophenone, 5'-chloro-2'-hydroxy-
  • Acetophenone,5-chloro-2-hydroxy-
  • 5'-Chloro-2'-hydroxyacetophenone,99%
  • Ethanone,1-(5-chloro-2-hydroxyphenyl)-
  • 1-(3-chlorophenyl)-2-hydroxyethan-1-one
  • ASISCHEM D38764
  • 2'-HYDROXY-5'-CHLORO ACETOPHENONE
  • 2-HYDROXY-5-CHLORO ACETOPHENONE
  • 1-(5-CHLORO-2-HYDROXYPHENYL)-1-ETHANONE
  • 1-(5-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
  • 1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE
  • AKOS BB-6937
  • 5-CHLORO-2-HYDROXYACETOPHENONE
  • 5'-Chloro-2'-hydroxyacetophenone 99%
  • 5'-Chloro-2'-hydroxyacetophenone, 98%+
  • oro-2'-hydroxyacetophenone
  • 2'-hydroxy-5'-chlorophenone
  • 1-(5 CHOLRO-2-HYDROXYPHENYL)ETHANONE
  • 2-HYDROXY-5-CHLOROACETOPHENONE -99+% CA
  • 2 HYDROXY-5-CHLOROACETOPHENONE-99+%
  • 5'-Chloro-2'-hydroxyacetophenone
  • 2'-Hydroxy-5'-chloroacetophenone
  • 5′-Chloro-2′-hydroxyacetophenone, CAS 1450-74-4
  • 1450-74-4
  • ClC6H3OHCOCH3
  • Organic Building Blocks
  • Ketones
  • Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Aromatic Acetophenones & Derivatives (substituted)
  • Phenoles and thiophenoles
  • Adehydes, Acetals & Ketones
  • Chlorine Compounds
  • Phenols
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • ADVANCED INT.