Isoxazole Property

Melting point:

-67.1°C

Boiling point:

93-95 °C(lit.)

Density 

1.078 g/mL at 25 °C(lit.)

vapor density 

2.4 (vs air)

refractive index 

n20/D 1.427(lit.)

Flash point:

48 °F

storage temp. 

2-8°C

solubility 

167g/l

pka

-2.0(at 25℃)

form 

clear liquid

color 

Colorless to Light yellow

BRN 

103773

InChIKey

CTAPFRYPJLPFDF-UHFFFAOYSA-N

CAS DataBase Reference

288-14-2(CAS DataBase Reference)

NIST Chemistry Reference

Isoxazole(288-14-2)

EPA Substance Registry System

Isoxazole (288-14-2)

Safety

Hazard Codes 

F,Xi

Risk Statements 

11

Safety Statements 

16-23/33-33-29-7/9

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

F 

10

Hazard Note 

Highly Flammable

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

Isoxazole Chemical Properties,Usage,Production

Description

Isoxazole, an important class of heterocycles, is a five membered heterocyclic compound that exhibits various pharmacological actions. It is present in some natural products such as ibotenic acid and is also used as a foundation for several drugs such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.

Chemical Properties

A colorless liquid resembling pyridine. It is soluble in water at room temperature up to six times its volume.

Uses

Natural insecticide.

Definition

ChEBI: Isoxazole is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. It is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of isoxazoles.

Preparation

Isoxazoles can be synthesized by various methods, such as the 1,3-dipolar cycloaddition reaction of nitrile oxides with alkynes, the reaction of hydroxylamine with 1,3-diketones or propiolic acid derivatives, etc.
www.organic-chemistry.org

General Description

Isoxazole(288-14-2) are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter.

Hazard

Narcotic and psychomimetic effects.

References

https://en.wikipedia.org/wiki/Isoxazole
https://pubchem.ncbi.nlm.nih.gov/compound/9254