ChemicalBook > CAS DataBase List > Isoxazole

Isoxazole

Product Name
Isoxazole
CAS No.
288-14-2
Chemical Name
Isoxazole
Synonyms
ISOXAZOLE;Isoxazolec;Isooxazole;1,2-Oxazole;Isoxazole>Isoxazole,99%;Isoxazole 99%;ISOXAZOLE 98+%;Isoxazole, 95%;Isoxazole, 98.5%
CBNumber
CB3485864
Molecular Formula
C3H3NO
Formula Weight
69.06
MOL File
288-14-2.mol
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Isoxazole Property

Melting point:
-67.1°C
Boiling point:
93-95 °C(lit.)
Density 
1.078 g/mL at 25 °C(lit.)
vapor density 
2.4 (vs air)
refractive index 
n20/D 1.427(lit.)
Flash point:
48 °F
storage temp. 
2-8°C
solubility 
167g/l
pka
-2.0(at 25℃)
form 
clear liquid
color 
Colorless to Light yellow
BRN 
103773
InChIKey
CTAPFRYPJLPFDF-UHFFFAOYSA-N
CAS DataBase Reference
288-14-2(CAS DataBase Reference)
NIST Chemistry Reference
Isoxazole(288-14-2)
EPA Substance Registry System
Isoxazole (288-14-2)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11
Safety Statements 
16-23/33-33-29-7/9
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
F 
10
Hazard Note 
Highly Flammable
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
151637
Product name
Isoxazole
Purity
99%
Packaging
5g
Price
$36
Updated
2025/07/31
Sigma-Aldrich
Product number
151637
Product name
Isoxazole
Purity
99%
Packaging
25g
Price
$116
Updated
2025/07/31
TCI Chemical
Product number
I0372
Product name
Isoxazole
Purity
>95.0%(GC)
Packaging
5g
Price
$39
Updated
2025/07/31
TRC
Product number
I779145
Product name
Isoxazole
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
024772
Product name
Isoxazole
Purity
98%
Packaging
100g
Price
$108
Updated
2021/12/16
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Isoxazole Chemical Properties,Usage,Production

Description

Isoxazole, an important class of heterocycles, is a five membered heterocyclic compound that exhibits various pharmacological actions. It is present in some natural products such as ibotenic acid and is also used as a foundation for several drugs such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.

Chemical Properties

A colorless liquid resembling pyridine. It is soluble in water at room temperature up to six times its volume.

Uses

Natural insecticide.

Definition

ChEBI: Isoxazole is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. It is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of isoxazoles.

Preparation

Isoxazoles can be synthesized by various methods, such as the 1,3-dipolar cycloaddition reaction of nitrile oxides with alkynes, the reaction of hydroxylamine with 1,3-diketones or propiolic acid derivatives, etc.
www.organic-chemistry.org

General Description

Isoxazole(288-14-2) are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter.

Hazard

Narcotic and psychomimetic effects.

References

https://en.wikipedia.org/wiki/Isoxazole
https://pubchem.ncbi.nlm.nih.gov/compound/9254

Isoxazole Preparation Products And Raw materials

Raw materials

Malonaldehyde bis(diethyl acetal) Hydroxylamine hydrochloride

Preparation Products

Zonisamide 2-Amino-5-chlorobenzophenone Clomazone 2-AMINO-5-CHLOROBENZOPHENONE OXIME 5-Chloro-2-(methylamino)benzophenone SULFISOXAZOLE ACETYL (200 MG) Isazophos 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE Risperidone Oxacillin sodium monohydrate
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Isoxazole Suppliers

Americas 1 Belgium 3 China 165 Czech Republic 1 Europe 3 France 1 Germany 7 India 28 Japan 3 Switzerland 3 United Kingdom 14 United States 43 Global 272
Pure Chemistry Scientific Inc.
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View Lastest Price from Isoxazole manufacturers

Career Henan Chemical Co
Product
Isoxazole 288-14-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

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