ChemicalBook > CAS DataBase List > 3-Chlorophenylboronic acid

3-Chlorophenylboronic acid

Product Name
3-Chlorophenylboronic acid
CAS No.
63503-60-6
Chemical Name
3-Chlorophenylboronic acid
Synonyms
3-CHLOROBENZENEBORONIC ACID;AKOS BRN-0010;RARECHEM AH PB 0179;3-Chlorophenylboroni;3-Chlorophenylboronic;3-CHLOROPHENYLBORNIC ACID;3-Chlorophenylboroic acid;3-CHLOROPHENYLBORONIC ACID;M-CHLOROPHENYLBORONIC ACID;3-Chlorophenylboornic acid
CBNumber
CB3486386
Molecular Formula
C6H6BClO2
Formula Weight
156.37
MOL File
63503-60-6.mol
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3-Chlorophenylboronic acid Property

Melting point:
185-189 °C(lit.)
Boiling point:
311.4±44.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
pka
7.55±0.10(Predicted)
form 
Crystalline Powder or Needles
color 
White to light yellow-green
Water Solubility 
Slightly soluble in water. soluble in ether, tetrahydrofuran,, dimethyl sulfoxide, dimethyl formamide, methanol.
BRN 
2936343
InChI
InChI=1S/C6H6BClO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H
InChIKey
SDEAGACSNFSZCU-UHFFFAOYSA-N
SMILES
B(C1=CC=CC(Cl)=C1)(O)O
CAS DataBase Reference
63503-60-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
36-37/39-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
417521
Product name
3-Chlorophenylboronic acid
Purity
≥95%
Packaging
1g
Price
$35.4
Updated
2024/03/01
Sigma-Aldrich
Product number
417521
Product name
3-Chlorophenylboronic acid
Purity
≥95%
Packaging
10g
Price
$202
Updated
2024/03/01
TCI Chemical
Product number
C1613
Product name
3-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
C1613
Product name
3-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$121
Updated
2024/03/01
Alfa Aesar
Product number
B24444
Product name
3-Chlorobenzeneboronic acid, 97%
Packaging
1g
Price
$20.65
Updated
2024/03/01
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3-Chlorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow-green crystalline powder

Uses

3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. It is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors6 among others.

Uses

suzuki reaction

Uses

Reactant involved in:

  • 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides
  • Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene
  • Cross-coupling reactions with diazoesters or potassium cyanate
  • Synthesis of biarylketones and phthalides
  • Synthesis of inhibitors including PDE4 inhibitors among others

Synthesis

Using m-dichlorobenzene as the starting material, iodine particles and 1,2-dibromoethane as the initiator reacts with magnesium in an organic solvent to prepare 3-chlorophenyl magnesium chloride. Then, the trimethyl borate is reacted with an organic solvent to prepare 3-chlorophenyl borate dimethyl ester. Finally, the product 3-chlorophenylboronic acid is obtained through hydrolysis, extraction, and crystallization.

Solubility in organics

3-Chlorophenylboronic acid can be dissolved in organic solvents such as N, N-dimethylformamide, ethyl acetate, and dichloromethane. In addition, it also has specific solubility in low-polarity and non-polar organic solvents, but 3-chlorophenylboronic acid has poor solubility in water.

3-Chlorophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chlorophenylboronic acid Suppliers

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View Lastest Price from 3-Chlorophenylboronic acid manufacturers

Shanghai UCHEM Inc.
Product
3-Chlorophenylboronic acid 63503-60-6
Price
US $471.00/kg
Min. Order
1kg
Purity
0.98
Supply Ability
100kg
Release date
2023-10-26
Henan Fengda Chemical Co., Ltd
Product
3-Chlorophenylboronic acid 63503-60-6
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Hebei Xinsheng New Material Technology Co., LTD.
Product
3-Chlorophenylboronic acid 63503-60-6
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 Ton
Release date
2023-10-31

63503-60-6, 3-Chlorophenylboronic acidRelated Search:

Zinc borate 1-Chloro-3-nitrobenzene 1,3-Dichlorobenzene Phenylboronic acid Citric acid Chlorphenamine maleate Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid Ascoric Acid 3,5-Dichlorophenylboronic acid 2,3,4-Trichlorophenylboronic acid 4-FLUORO-3-CHLOROPHENYLBORONIC ACID 2,3-Dichlorophenylboronic acid (3,4,5-Trichlorophenyl)boronic acid 3,4-Dichlorophenylboronic acid 5-CHLORO-2-METHYLPHENYLBORONIC ACID 5-CHLORO-2-ETHOXYPHENYLBORONIC ACID

  • B-(3-chlorophenyl)-boronic acid
  • 3-Chlorobenzeneboronic acid 98%
  • 3-Chlorophenylboronic
  • 3-Chlorophenylboornic acid
  • RARECHEM AH PB 0179
  • 3-CHLOROPHENYLBORNIC ACID
  • 3-CHLOROPHENYLBORONIC ACID
  • 3-CHLOROBENZENEBORONIC ACID
  • 3-Chlorophenylboronic acid, CAS 63503-60-6, C6H6BClO2
  • M-CHLOROPHENYLBORONIC ACID
  • AKOS BRN-0010
  • 3-CHLOROBENZENEBORONIC ACID / 3-CHLOROPHENYLBORONIC ACID
  • 3-CHLOROPHENYLBORONIC ACID 98%
  • 3-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
  • 3-Chlorophenylboronic acid,97%
  • 3-Chlorophenylboronic acid ,98%
  • 3-Chlorophenylboroni
  • 3-Chlorophenylboronic acid, May contain varying amounts of anhydride, 97%
  • 3-Chlorophenylboronic acid, 97% 5GR
  • BORONICACID, B-(3-CHLOROPHENYL)-
  • m-Chlorobenzeneboronic acid
  • 3-Chlorophenylboronic acid, 97%, May contain varying aMounts of anhydride
  • 63503-60-6 3-Chlorophenylboronic acid
  • 3-Chlorophenylboroic acid
  • 63503-60-6
  • C6H6BO2Cl
  • BORONIC ACID
  • Aryl
  • Boronic Acids and Derivatives
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Organometallic Reagents
  • Boronate Ester
  • Potassium Trifluoroborate
  • Boronic acids
  • Aryl
  • Halogenated
  • Organoborons
  • Boronic Acid
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Substituted Boronic Acids
  • blocks
  • BoronicAcids
  • Boronic Acid series