2,3-Dichlorophenylboronic acid
- Product Name
- 2,3-Dichlorophenylboronic acid
- CAS No.
- 151169-74-3
- Chemical Name
- 2,3-Dichlorophenylboronic acid
- Synonyms
- AKOS BRN-0159;CAS:151169-74-3;RARECHEM AH PB 0262;3,4-Dichlorophenylboric acid;2,3-Dichlorophenylboronicaci;2,3-Dichloropheyl Boronic Acid;2,3-Dichlorophenylbrornic acid;2,3-DICHLOROPHENYLBORONIC ACID;2,3-DICHLOROBENZENEBORONIC ACID;B-(2,3-Dichlorophenyl)boronic acid
- CBNumber
- CB6768276
- Molecular Formula
- C6H5BCl2O2
- Formula Weight
- 190.82
- MOL File
- 151169-74-3.mol
2,3-Dichlorophenylboronic acid Property
- Melting point:
- 125 °C (dec.) (lit.)
- Boiling point:
- 349.8±52.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in methanol.
- pka
- 7.26±0.58(Predicted)
- form
- Powder
- color
- White
- InChI
- InChI=1S/C6H5BCl2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H
- InChIKey
- TYIKXPOMOYDGCS-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC(Cl)=C1Cl)(O)O
- CAS DataBase Reference
- 151169-74-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 514047
- Product name
- 2,3-Dichlorophenylboronic acid
- Packaging
- 5g
- Price
- $57
- Updated
- 2023/06/20
- Product number
- 514047
- Product name
- 2,3-Dichlorophenylboronic acid
- Packaging
- 25g
- Price
- $219
- Updated
- 2023/06/20
- Product number
- D3434
- Product name
- 2,3-Dichlorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- D3434
- Product name
- 2,3-Dichlorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- D436600
- Product name
- 2,3-Dichlorophenylboronic acid
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
2,3-Dichlorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
suzuki reaction
Uses
2,3-Dichlorophenylboronic Acid is used as a reagent in the synthesis of trisubstituted thiazoles as Cdc7 kinase inhibitors. It is also used as a reagent in the synthesis of aminoarylpyridazines as selective CB2 agonists for treatment of inflammatory pain.
Synthesis
121-43-7
56961-77-4
151169-74-3
1. A solution was prepared by dissolving 1-bromo-2,3-dichlorobenzene (20 g, 0.088 mol, Aldrich) in anhydrous tetrahydrofuran (44.24 ml) under the protection of dry inert gas. 2. The above solution was slowly added dropwise to anhydrous tetrahydrofuran (16 ml) of n-butyllithium (1.6 M in hexane, 66.36 ml, 0.11 mol) solution, with the reaction temperature strictly controlled below -65°C. 3. After the dropwise addition, the light yellow suspension formed was stirred continuously at -78°C for 75 min. 4. Trimethyl borate (13.28 ml, 12.16 g, 0.12 mol) was slowly added while keeping the temperature below -55°C. 5. The reaction mixture was gradually warmed up to room temperature and stirred overnight. 6. Excess n-butyllithium was quenched with water (30 ml) and the reaction mixture was subsequently concentrated under reduced pressure.7. The concentrated residue was suspended in water and acidified with 2M hydrochloric acid (10 ml).8. The insoluble solid was collected by filtration, washed well with water and then dried.9. The dried solid was suspended in petroleum ether at 60-80°C, stirred at room temperature for 10 min, filtered and dried under vacuum.10. Finally, 8.42 g of 2,3-dichlorophenylboronic acid was obtained in 50% yield with a melting point of 235-238 °C.
References
[1] Patent: US6255307, 2001, B1
2,3-Dichlorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dichlorophenylboronic acid manufacturers
- Product
- 2,3-Dichlorophenylboronic acid 151169-74-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- ≥99.0%
- Supply Ability
- 1000kg
- Release date
- 2023-04-23
- Product
- 2,3-Dichlorophenylboronic acid 151169-74-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12