Uses
ChemicalBook > CAS DataBase List > Menbutone

Menbutone

Uses
Product Name
Menbutone
CAS No.
3562-99-0
Chemical Name
Menbutone
Synonyms
menbutone;genabil;menbuton;fel-bis;Icteryl;SC 1749;naftobil;genabilin;epanaftol;Meng Meng
CBNumber
CB3489226
Molecular Formula
C15H14O4
Formula Weight
258.27
MOL File
3562-99-0.mol
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Menbutone Property

Melting point:
172-173°
Boiling point:
361.52°C (rough estimate)
Density 
1.2105 (rough estimate)
refractive index 
1.4872 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Ethanol (Slightly, Heated)
form 
Solid
pka
4.44±0.17(Predicted)
color 
White to Off-White
InChI
InChI=1S/C15H14O4/c1-19-14-8-6-11(13(16)7-9-15(17)18)10-4-2-3-5-12(10)14/h2-6,8H,7,9H2,1H3,(H,17,18)
InChIKey
FHGJSJFIQNQBCK-UHFFFAOYSA-N
SMILES
C12C=CC=CC1=C(OC)C=CC=2C(=O)CCC(=O)O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M218700
Product name
Menbutone
Packaging
1g
Price
$65
Updated
2021/12/16
ApexBio Technology
Product number
C6958
Product name
Menbutone
Packaging
100mg
Price
$80
Updated
2021/12/16
Matrix Scientific
Product number
089746
Product name
4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid
Purity
95+%
Packaging
5g
Price
$101
Updated
2021/12/16
ApexBio Technology
Product number
C6958
Product name
Menbutone
Packaging
200mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
089746
Product name
4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid
Purity
95+%
Packaging
1g
Price
$38
Updated
2021/12/16
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Menbutone Chemical Properties,Usage,Production

Uses

Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.

Originator

Hepalande, Delalande ,W. Germany ,1977

Uses

Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.

Definition

ChEBI: Menbutone is a butanone.

Manufacturing Process

395 parts of (α-methoxynaphthalene and 265 parts of succinic anhydride are dissolved in 8,000 parts of dry benzene at room temperature. The resulting solution is stirred and 710 parts of anhydrous aluminum chloride are added over a period of twenty minutes. During the addition the temperature of the reaction mixture rises to about 60°C to 70°C. After the addition the reaction mixture is stirred for fifteen or twenty minutes at 60°C to 70°C and then refluxed for one hour. The hot reaction mixture is then poured onto a mixture of 5,000 parts of ice and 900 parts of concentrated hydrochloric acid. The benzene is removed by steam distillation and the hot aqueous residue is filtered to remove the insoluble β-(1-methoxy-4-naphthoyl)-propionic acid. The residue of the latter is dried and then dissolved in 16,000 parts of hot water containing 300 parts of sodium carbonate. The hot solution is treated with activated charcoal, filtered while hot, chilled and acidified. The residue of purified acid is collected on a filter, washed with water, and dried at 65°C. A yield of 552 parts of purified β-(1-methoxy)-4-naphthoyl)propionic acid, melting at 172°C to 173°C is obtained.

Therapeutic Function

Choleretic

Synthesis

Menbutone is prepared by the reaction of succinic acid anhydride and 1-Methoxynaphthalene. The steps are as follows:
15.8 g of 1-methoxynaphthalene and 10.0 g of succinic anhydride were dissolved in 120 mL of dichloromethane,Stir, Cooling to 1 ~ 3 ° C, Divided into three batches of anhydrous aluminum trichloride 15.0 grams, The addition process takes about 20 minutes, The solution was then heated to 35 ± 2 ° C, Insulation reaction 6 hours (5.5 ~ 6.5 hours range), After the reaction is complete, The reaction solution was poured into an ice-water mixture (200 g of ice and 300 g of water) for 30 minutes,Standing, analysiscrystal, Filter, The filtrate was heated and distilled to recover dichloromethane, The cake is the crude of the ketone ketone; And then the crude ketoprofen water as a solvent by 2-3 times recrystallization, Activated carbon decolorization, Demon ketone boutique. The mass of the present product of the compound was 22.3 g, Melting point of 176 ~ 179 ° C, The yield was 86.4%.

Menbutone Preparation Products And Raw materials

Raw materials

Preparation Products

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Menbutone Suppliers

Shandong Jihao Biotechnology Co., Ltd.
Tel
0531-69958659 15668363232
Email
8598038@qq.com
Country
China
ProdList
45
Advantage
58
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
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View Lastest Price from Menbutone manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Menbutone 3562-99-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-28
shandong perfect biotechnology co.ltd
Product
Menbutone 3562-99-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99% HPLC
Supply Ability
5 ton
Release date
2023-07-04

3562-99-0, MenbutoneRelated Search:


  • genabil
  • genabilicacid
  • genabilin
  • ido-genabil
  • menbuton
  • menbutone
  • naftobil
  • 3-(4-methoxy-1-naphthoyl)-propionicaci
  • 4-methoxy-gamma-oxo-1-naphthalenebutanoicaci
  • acidebeta-(1-methoxy-4-naphthoyl)propionique
  • beta-(1-methoxy-4-naphthoyl)-propionsaeure
  • epanaftol
  • fel-bis
  • nafto-epatina
  • P-METHOXYNAPHTHOYLPROPIONIC ACID
  • 3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID
  • Icteryl
  • SC 1749
  • 1-Methoxy-4-(.beta.-carboxyethylcarbonyl)-naphthalene
  • 4-keto-4-(4-methoxy-1-naphthyl)butyric acid
  • 4-(4-Methoxy-[1]naphthyl)-4-oxo-butyric acid
  • 1-Naphthalenebutanoic acid, 4-methoxy-g-oxo-
  • Meng Meng
  • 3-(4'-METHOXYNAPHTHOYL) PROPIONIC ACID
  • MENBUTONE STANDARD
  • 1-Naphthalenebutanoic acid, 4-methoxy-γ-oxo-
  • 3562-99-0 3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID C15H14O4
  • Meng cloth ketone
  • 3562-99-0
  • Aromatic Propionic Acids