4-(4-Methoxyphenyl)butyric acid

Product Name: 4-(4-Methoxyphenyl)butyric acid
CAS No.: 4521-28-2
Chemical Name: 4-(4-Methoxyphenyl)butyric acid
Synonyms: 4-(4-METHOXYPHENYL)BUTANOIC ACID;4-(4-Methoxyphenyl)b;4-methoxyphenylbutyricacid;4-Methoxybenzenebutyric acid;4-Methoxybenzenebutanoic acid;4-(4-Methoxyphenyl)butyricaci;4-(p-methoxyphenyl)butyricacid;4-(4-METHOXYPHENYL)BUTYRIC ACID;Benzenebutanoic acid, 4-methoxy-;Allisartan Isoproxil Impurity 22
CBNumber: CB4746722
Molecular Formula: C11H14O3
Formula Weight: 194.23
MOL File: 4521-28-2.mol

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4-(4-Methoxyphenyl)butyric acid Property

Melting point:: 56-59 °C (lit.)
Boiling point:: 196 °C / 10mmHg
Density: 1.116±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Slightly soluble in methanol. Insoluble in chloroform.
form: Powder
pka: 4.76±0.10(Predicted)
color: Cream to slightly yellow
Water Solubility: 994.9g/L(37 ºC)
BRN: 2416568
InChI: InChI=1S/C11H14O3/c1-14-10-7-5-9(6-8-10)3-2-4-11(12)13/h5-8H,2-4H2,1H3,(H,12,13)
InChIKey: LZHMNCJMXQKSBY-UHFFFAOYSA-N
SMILES: C1(CCCC(O)=O)=CC=C(OC)C=C1
LogP: 2.33
CAS DataBase Reference: 4521-28-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-(4-Methoxyphenyl)butyric acid(4521-28-2)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 163384
Product name: 4-(4-Methoxyphenyl)butyric acid
Purity: 97%
Packaging: 5g
Price: $107
Updated: 2023/01/07

Sigma-Aldrich

Product number: 163384
Product name: 4-(4-Methoxyphenyl)butyric acid
Purity: 97%
Packaging: 25g
Price: $187
Updated: 2021/12/16

TCI Chemical

Product number: M2037
Product name: 4-(4-Methoxyphenyl)butyric Acid
Purity: >95.0%(GC)
Packaging: 5g
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: M2037
Product name: 4-(4-Methoxyphenyl)butyric Acid
Purity: >95.0%(GC)
Packaging: 25g
Price: $220
Updated: 2025/07/31

TRC

Product number: M329568
Product name: 4-(4-Methoxyphenyl)butyric acid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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4-(4-Methoxyphenyl)butyric acid Chemical Properties,Usage,Production

Chemical Properties

cream to slightly yellow powder

Uses

4-(4-Methoxyphenyl)butyric acid on demethylation with pyridinium hydrochloride affords 4-hydroxyphenylbutyric acid, a key starting material for the synthesis of preclinical candidate LY518674.

Synthesis

3153-44-4

4521-28-2

Step G: 4-(4-methoxyphenyl)-4-oxobutanoic acid (40 g) was suspended in a solvent mixture of acetic acid (100 ml) and tetrahydrofuran (THF, 100 ml). To this suspension, 10% palladium-carbon catalyst (50% wet weight, 4 g) was added, followed by stirring the reaction mixture under hydrogen atmosphere (0.4 MPa) for 9 hours. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove the catalyst. Toluene was added to the filtrate and the solvent was subsequently removed by distillation under reduced pressure to afford 4-(4-methoxyphenyl)butanoic acid in quantitative yield. The product was characterized by 1H-NMR (CDCl3): δ 1.89 (m, 2H), 2.32 (t, J=7.3 Hz, 2H), 2.58 (t, J=7.4 Hz, 2H), 3.73 (s, 3H), 6.78-6.82 (m, 2H), 7.03-7.08 (m, 2H), 10.96 (brs, 1H).

References

[1] Patent: EP1726587, 2006, A1. Location in patent: Page/Page column 33
[2] Chemistry of Natural Compounds, 2003, vol. 39, # 4, p. 404 - 406
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998, vol. 37, # 3, p. 281 - 284
[4] Research on Chemical Intermediates, 2017, vol. 43, # 10, p. 5933 - 5942
[5] Journal of Organic Chemistry, 1990, vol. 55, # 11, p. 3537 - 3543

4-(4-Methoxyphenyl)butyric acid Preparation Products And Raw materials

Raw materials

Diethylene glycol Hydrazinium hydroxide solution Potassium hydroxide Anisole Succinic anhydride Aluminum chloride Diethyl ether Ethyl acetate Methanol Nitrobenzene Magnesium sulfate PETROLEUM ETHER Citric acid

Preparation Products

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4-(4-Methoxyphenyl)butyric acid Suppliers

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View Lastest Price from 4-(4-Methoxyphenyl)butyric acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000kgs
Release date: 2025-05-23

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-05-23

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(4-Methoxyphenyl)butyric acid 4521-28-2
Price: US $25.00-11.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-12

4521-28-2, 4-(4-Methoxyphenyl)butyric acidRelated Search:

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4-(4-Methoxyphenyl)b

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Allisartan Isoproxil Impurity 22

4-(4-Methoxyphenyl)Butanoic Acid 4-(4-)

4521-28-2

CH3OC6H4CH23CO2H

C11H13O3

CARBOXYLIC ACID

Organic Building Blocks

Carbonyl Compounds

Building Blocks

C11 to C12

Carboxylic Acids

Organic Building Blocks

C11 to C12

Carbonyl Compounds

Carboxylic Acids

Benzene derivatives

Building Blocks

C11 to C12

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis