Menbutone
Uses- Product Name
- Menbutone
- CAS No.
- 3562-99-0
- Chemical Name
- Menbutone
- Synonyms
- menbutone;genabil;menbuton;fel-bis;Icteryl;SC 1749;naftobil;genabilin;epanaftol;Meng Meng
- CBNumber
- CB3489226
- Molecular Formula
- C15H14O4
- Formula Weight
- 258.27
- MOL File
- 3562-99-0.mol
Menbutone Property
- Melting point:
- 172-173°
- Boiling point:
- 361.52°C (rough estimate)
- Density
- 1.2105 (rough estimate)
- refractive index
- 1.4872 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Ethanol (Slightly, Heated)
- form
- Solid
- pka
- 4.44±0.17(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C15H14O4/c1-19-14-8-6-11(13(16)7-9-15(17)18)10-4-2-3-5-12(10)14/h2-6,8H,7,9H2,1H3,(H,17,18)
- InChIKey
- FHGJSJFIQNQBCK-UHFFFAOYSA-N
- SMILES
- C12C=CC=CC1=C(OC)C=CC=2C(=O)CCC(=O)O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M218700
- Product name
- Menbutone
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C6958
- Product name
- Menbutone
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 089746
- Product name
- 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- C6958
- Product name
- Menbutone
- Packaging
- 200mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 089746
- Product name
- 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
Menbutone Chemical Properties,Usage,Production
Uses
Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.
Originator
Hepalande, Delalande ,W. Germany ,1977
Uses
Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.
Definition
ChEBI: Menbutone is a butanone.
Manufacturing Process
395 parts of (α-methoxynaphthalene and 265 parts of succinic anhydride are dissolved in 8,000 parts of dry benzene at room temperature. The resulting solution is stirred and 710 parts of anhydrous aluminum chloride are added over a period of twenty minutes. During the addition the temperature of the reaction mixture rises to about 60°C to 70°C. After the addition the reaction mixture is stirred for fifteen or twenty minutes at 60°C to 70°C and then refluxed for one hour. The hot reaction mixture is then poured onto a mixture of 5,000 parts of ice and 900 parts of concentrated hydrochloric acid. The benzene is removed by steam distillation and the hot aqueous residue is filtered to remove the insoluble β-(1-methoxy-4-naphthoyl)-propionic acid. The residue of the latter is dried and then dissolved in 16,000 parts of hot water containing 300 parts of sodium carbonate. The hot solution is treated with activated charcoal, filtered while hot, chilled and acidified. The residue of purified acid is collected on a filter, washed with water, and dried at 65°C. A yield of 552 parts of purified β-(1-methoxy)-4-naphthoyl)propionic acid, melting at 172°C to 173°C is obtained.
Therapeutic Function
Choleretic
Synthesis
Menbutone is prepared by the reaction of succinic acid anhydride and 1-Methoxynaphthalene. The steps are as follows:
15.8 g of 1-methoxynaphthalene and 10.0 g of succinic anhydride were dissolved in 120 mL of dichloromethane,Stir, Cooling to 1 ~ 3 ° C, Divided into three batches of anhydrous aluminum trichloride 15.0 grams, The addition process takes about 20 minutes, The solution was then heated to 35 ± 2 ° C, Insulation reaction 6 hours (5.5 ~ 6.5 hours range), After the reaction is complete, The reaction solution was poured into an ice-water mixture (200 g of ice and 300 g of water) for 30 minutes,Standing, analysiscrystal, Filter, The filtrate was heated and distilled to recover dichloromethane, The cake is the crude of the ketone ketone; And then the crude ketoprofen water as a solvent by 2-3 times recrystallization, Activated carbon decolorization, Demon ketone boutique. The mass of the present product of the compound was 22.3 g, Melting point of 176 ~ 179 ° C, The yield was 86.4%.
Menbutone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Menbutone manufacturers
- Product
- Menbutone 3562-99-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 1tons
- Release date
- 2024-04-28
- Product
- Menbutone 3562-99-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min
- Supply Ability
- 10000kg
- Release date
- 2024-12-26
- Product
- Menbutone 3562-99-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99% HPLC
- Supply Ability
- 5 ton
- Release date
- 2023-07-04