ChemicalBook > CAS DataBase List > 3,5-Dimethylisoxazole-4-boronic acid

3,5-Dimethylisoxazole-4-boronic acid

Uses

Product Name: 3,5-Dimethylisoxazole-4-boronic acid
CAS No.: 16114-47-9
Chemical Name: 3,5-Dimethylisoxazole-4-boronic acid
Synonyms: (3,5-DIMETHYLISOXAZOL-4-YL)BORONIC ACID;AKOS BRN-0206;TIMTEC-BB SBB004160;CHEMBRDG-BB 3200973;DiMethylisoxazole-4-boronic zcid;3,5-Dimethylisoxazole-4-boronicaci;3,5-DIMETHYISOXAZOLE-4-BORONIC ACID;3,5-DIMETHYLISOXAZOLE-4-BORONIC ACID;3,5-DIMETHYL-4-ISOXAZOLEBORONIC ACID;3,5-DIMETHYL-4-ISOXAZOLYLBORONIC ACID
CBNumber: CB3489923
Molecular Formula: C5H8BNO3
Formula Weight: 140.93
MOL File: 16114-47-9.mol

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3,5-Dimethylisoxazole-4-boronic acid Property

Melting point:: 108-113 °C
Boiling point:: 334.0±52.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder or crystals
pka: 6.46±0.58(Predicted)
Appearance: White to off-white Solid
InChIKey: DIIFZCPZIRQDIJ-UHFFFAOYSA-N
CAS DataBase Reference: 16114-47-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 36/37/39-3-26-36
WGK Germany: nwg
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 720410
Product name: 3,5-Dimethylisoxazol-4-yl-4-boronic acid
Packaging: 1g
Price: $40.17
Updated: 2025/07/31

Sigma-Aldrich

Product number: 720410
Product name: 3,5-Dimethylisoxazol-4-yl-4-boronic acid
Packaging: 250mg
Price: $20
Updated: 2023/06/20

TRC

Product number: D474365
Product name: 3,5-Dimethylisoxazole-4-boronicacid
Packaging: 5g
Price: $90
Updated: 2021/12/16

TRC

Product number: D474365
Product name: 3,5-Dimethylisoxazole-4-boronicacid
Packaging: 10g
Price: $140
Updated: 2021/12/16

TRC

Product number: D474365
Product name: 3,5-Dimethylisoxazole-4-boronicacid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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3,5-Dimethylisoxazole-4-boronic acid Chemical Properties,Usage,Production

Uses

3,5-Dimethylisoxazole-4-boronic acid can be used as an intermediate in pharmaceutical and chemical synthesis.

Chemical Properties

White to light yellow crystal powde

Synthesis

10558-25-5

5419-55-6

16114-47-9

The general procedure for the synthesis of 3,5-dimethylisoxazole-4-boronic acid from 4-bromo-3,5-dimethylisoxazole and triisopropyl borate is as follows: Synthesis of intermediate 106 (3,5-dimethyl-1,2-oxazol-4-ylboronic acid): 1. A solution of 4-bromo-3,5-dimethyl-1,2-oxazole (4.0 g, 22.7 mmol) in THF (40 mL) was added to a 500 mL three-necked flask fitted with a magnetic stirrer and the reaction system was cooled to -78°C. 2. n-Butyllithium (28.4 mL, 1.6 M solution, 45.0 mmol) was added dropwise to the reaction system with stirring and stirring was continued for about 30 minutes at -65 °C. 3. the temperature of the reaction mixture was raised to -78 °C, followed by the addition of triisopropyl borate (12.81 g, 68.0 mmol). 4. After the temperature of the reaction system was brought to room temperature, stirring was continued for about 16 hours. 5. Upon completion of the reaction, the solvent was removed under reduced pressure, the reaction was quenched with saturated NH4Cl solution and extracted with ethyl acetate. 6. The organic layer was washed with water, dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. 7. The crude product obtained was purified by silica gel column chromatography to finally obtain the target compound in white solid form (0.4 g, yield: 12.5%).

References

[1] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 148-149
[2] Patent: WO2013/24104, 2013, A1. Location in patent: Page/Page column 8

3,5-Dimethylisoxazole-4-boronic acid Preparation Products And Raw materials

Raw materials

Trimethyl borate 3,5-Dimethylisoxazole Tetrahydrofuran Diethyl ether Iodine Nitric acid Bromoethane Magnesium

Preparation Products

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View Lastest Price from 3,5-Dimethylisoxazole-4-boronic acid manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3,5-Dimethylisoxazole-4-boronic acid 16114-47-9
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Honest Joy Holdings Limited

Product: 3,5-Dimethylisoxazole-4-boronic acid 16114-47-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: 3,5-Dimethylisoxazole-4-boronic acid 16114-47-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customise
Release date: 2018-08-09

16114-47-9, 3,5-Dimethylisoxazole-4-boronic acidRelated Search:

3,5-Dimethylisoxazole 3,5-Dimethylbenzoic acid 2,5-Dimethylpyridine Isoxazole Dimethyl sulfoxide ISOXAFLUTOLE Dimethyl fumarate Sulfamethoxazole 1,3-Bis(isocyanatomethyl)benzene Dimethyl sulfate Dimethyl sulfide Dacthal Dimethyl carbonate Dimethyl ether Poly(dimethylsiloxane) Sulfisoxazole Dimethyl phthalate ETHANE

AKOS BRN-0206

3,5-DIMETHYISOXAZOLE-4-BORONIC ACID

CHEMBRDG-BB 3200973

3,5-DIMETHYL-4-ISOXAZOLYLBORONIC ACID

3,5-DIMETHYL-4-ISOXAZOLEBORONIC ACID

3,5-DIMETHYLISOXAZOLE-4-BORONIC ACID

(3,5-DIMETHYLISOXAZOL-4-YL)BORONIC ACID

TIMTEC-BB SBB004160

3,5-DIMETHYL-4-ISOXAZOLYLBORONIC ACID(CONTAINS UPTO 30% BORONIC ANHYDRIDE)

3,5-DIMETHYLISOXAZOLE-4-BORONIC ACID (97%)

3,5-Dimethyl-4-isoxazolylboronic acid (contains up to 30% anhydride)

3,5-Dimethylisoxazole-4-boronic acid,98%

3,5-dimethylisoxazol-4-yl-4-boronic acid

3,5-Dimethyl-4-isoxazolylboronic acid , May contain varying amounts of anhydride, 97%

(3,5-dimethylisoxazol-4-yl)boronic acid(SALTDATA: FREE)

DiMethylisoxazole-4-boronic zcid

Boronic acid, B-(3,5-diMethyl-4-isoxazolyl)-

3,5-DiMethylisoxazole-4-boronic acid (contains varying aMounts of anhydride)

3,5-DiMethyl-4-isoxazolylboronic acid, 97%, May contain varying aMounts of anhydride

4-Borono-3,5-dimethylisoxazole, 3,5-Dimethyl-1,2-oxazole-4-boronic acid

(diMethyl-1,2-oxazol-4-yl)boronic acid

(3,5-dimethyl-1,2-oxazol-4-yl)boronic acid

3,5-Dimethylisoxazole-4-boronicaci

3,5-Dimethylisoxazole-4-boronic acid - [D2900]

16114-47-9

C5H8BNO3

C5H8NO3B

BORONIC ACID

Boronic Acids & Esters

Oxazoles, Isoxazoles & Benzoxazoles

Boronic acids

Boronic acid

Isoxazole

Organoborons

Boronic Acids & Esters

Boric Acid| Boric Acid Ester| Potassium Trifluoroborate