Epirubicin hydrochloride
- Product Name
- Epirubicin hydrochloride
- CAS No.
- 56390-09-1
- Chemical Name
- Epirubicin hydrochloride
- Synonyms
- Ebewe;Adrial;CS-1396;Ellence;Epirubin HCI;Epirubicin Ebewe;Farmorubicin-RTU;(8s-cis)-rochlorid;EpirubicinHc,LEp5,;Epirubicin HCl API
- CBNumber
- CB3501568
- Molecular Formula
- C27H30ClNO11
- Formula Weight
- 579.9802
- MOL File
- 56390-09-1.mol
Epirubicin hydrochloride Property
- Melting point:
- 185°C dec.
- alpha
- D20 +274° (c = 0.01 in methanol)
- RTECS
- QI9295750
- Flash point:
- 443.8℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO to 100mM, or in ethanol to 10mM
- form
- powder
- color
- red to deep red
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
- InChIKey
- MWWSFMDVAYGXBV-UAOJCOQHSA-N
- SMILES
- C12=C(O)C3=C(C(=O)C4=C(C3=O)C=CC=C4OC)C(O)=C1[C@@]([H])(O[C@H]1O[C@@H](C)[C@H](O)[C@@H](N)C1)C[C@](O)(C(=O)CO)C2.Cl
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-63-62-46-40
- Safety Statements
- 36/37/38-45-46
- WGK Germany
- 3
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H340May cause genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E9406
- Product name
- Epirubicin hydrochloride
- Purity
- ≥90% (HPLC)
- Packaging
- 5mg
- Price
- $217
- Updated
- 2024/03/01
- Product number
- BP992
- Product name
- Epirubicin hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 1237382
- Product name
- Epirubicin hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $1340
- Updated
- 2024/03/01
- Product number
- J60411
- Product name
- Epirubicin hydrochloride
- Packaging
- 10mg
- Price
- $244
- Updated
- 2024/03/01
- Product number
- J60411
- Product name
- Epirubicin hydrochloride
- Packaging
- 100mg
- Price
- $944
- Updated
- 2024/03/01
Epirubicin hydrochloride Chemical Properties,Usage,Production
Description
Epirubicin hydrochloride is an antitumor antibiotic which is epimeric with doxorubicin a t the 4’-position of the amino sugar moiety. It has shown utility in the treatment of mammary, gastric, colorectal, pulmonary and ovarian carcinomas, as well as malignant lymphoma and melanoma and soft tissue sarcoma. It is reported to be less sardiotoxic than doxorubicin.
Description
Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-
Chemical Properties
Orange-Red Crystalline Solid
Originator
Erbamont (Italy)
Uses
Used as an antineoplastic
Uses
Cell-permeable anthracycline anti-tumor antibiotic
brand name
Ellence(Pfizer);FARMORUBICIN.
Biological Functions
This stereoisomer of doxorubicin has the 4′-hydroxy group of the daunosamine sugar oriented in the β-position . Epirubicin will be slowly reduced to the active C13 alcohol (epirubicinol), giving it a 30- to 38-hour half life, which is similar to that of doxorubicin. Unlike doxorubicinol, however, which was equally active with doxorubicin, epirubicinol has only one-tenth the activity of its parent drug and is not believed to contribute significantly to the therapeutic action of this agent.
Biological Activity
Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
Clinical Use
Epirubicin is indicated for use in breast cancer, and the starting dose is 100 to 120 mg/m2 (compared to a starting dose of 60–75 mg/m2 for doxorubicin).
Side effects
The side effects and precautions are as outlined previously for doxorubicin, although there is a lower risk of serious myocardial toxicity or myelotoxicity.
Drug interactions
Potentially hazardous interactions with other drugsAntipsychotics: avoid with clozapine - increased risk of agranulocytosis.Ciclosporin: increased risk of neurotoxicityCytotoxics: possible increased risk of cardiotoxicity with trastuzumab - avoid for up to 28 weeks after stopping trastuzumab.Ulcer-healing drugs: concentration increased by cimetidine. Vaccines: avoid with live vaccines
Metabolism
Cleavage of the epimerized sugar will occur before excretion, generating an aglycone that is indistinguishable from that generated by doxorubicin. Although excretion is primarily biliary, dosage reduction in severe renal impairment, as well as in hepatic dysfunction, is warranted.
storage
+4°C
References
1) Cersosimo?et al. (1986),?Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol.,?4?425 2) Spadari?et al. (1986),?DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res.,?6?935 3) Minotti?et al. (2004),?Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev.,?56?185 4) Mercuro?et al. (2007),?Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist,?12?1124
Epirubicin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Epirubicin hydrochloride manufacturers
- Product
- Epirubicin hydrochloride 56390-09-1
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-20
- Product
- Epirubicin hydrochloride 56390-09-1
- Price
- US $9.00-60.00/g
- Min. Order
- 10g
- Purity
- min99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-22
- Product
- Epirubicin hydrochloride 56390-09-1
- Price
- US $0.00/g/Bag
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2021-10-18