ChemicalBook > CAS DataBase List > PROSTAGLANDIN A1

PROSTAGLANDIN A1

Product Name
PROSTAGLANDIN A1
CAS No.
14152-28-4
Chemical Name
PROSTAGLANDIN A1
Synonyms
PGA1;Prostaglandin A;Prostagladin E1;C04685;pga(sub1);pga(sup1);Prostagladin A;PROSTAGLANDIN A1;PROSTAGLANDINS A1;prostaglandina(sup1)
CBNumber
CB3666883
Molecular Formula
C20H32O4
Formula Weight
336.47
MOL File
14152-28-4.mol
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PROSTAGLANDIN A1 Property

Melting point:
43°C
Boiling point:
392.93°C (rough estimate)
Density 
1.0192 (rough estimate)
refractive index 
1.4434 (estimate)
storage temp. 
-20°C
solubility 
acetone: 10 mg/mL, clear
form 
White solid.
pka
4.77±0.10(Predicted)
color 
Off-white
BRN 
2003401
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
GY5977900
F 
8-10
HS Code 
2937500000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7265
Product name
Prostaglandin A1
Purity
synthetic
Packaging
1mg
Price
$161
Updated
2024/03/01
Sigma-Aldrich
Product number
1578500
Product name
Prostaglandin A1
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$3090
Updated
2024/03/01
Cayman Chemical
Product number
10010
Product name
Prostaglandin A1
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10010
Product name
Prostaglandin A1
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
P7265
Product name
Prostaglandin A1
Purity
synthetic
Packaging
5mg
Price
$559
Updated
2024/03/01
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PROSTAGLANDIN A1 Chemical Properties,Usage,Production

Description

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 μM.

Uses

Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.

Definition

ChEBI: Prostaglandin A1 is a prostaglandins A. It is a conjugate acid of a prostaglandin A1(1-).

General Description

Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).

Biochem/physiol Actions

Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients.

Enzyme inhibitor

This eicosanoid (FWfree-acid = 336.47 g/mol; CAS 14152-28-4; Symbol: PGA1) induces apoptosis and stimulates the expression of stress genes. The structure and role of the prostaglandin A1 was investigated by Bergstr?m and Samuelsson, who shared the 1982 Nobel Prize in Physiology or Medicine for their pioneering work on the eicosanoids. Target(s): CYP4F2; DNA topoisomerase II; HIV-1 transcription; 3ahydroxysteroid dehydrogenase, NADP+-dependent; IkB kinase; Mayaro virus replication; stress-induced NF-kB activation; and virus protein biosynthesis, or translation.

References

1) Lee et al. (1972) Renal effects of prostaglandin A1 in patients with essential hypertension; Kidney Int. 1 254 2) Toppozada et al. (1988) Treatment of preeclampsia with prostaglandin A1; Am. J. Obstet. Gynecol. 159 160 3) Rossi et al. (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase; Nature 403 103 4) Mandal et al. (2005), Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation; J. Immunol. 175 6271 5) Carta et al. (2014) Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-kB activity; Prostaglandins Leukot. Essential Fatty Acids 91 311 6) Tsukimoto et al. (2015) A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors; Antiviral Res. 117 1 7) Diez-Dacal et al. (2011) Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity; Cancer Res. 71 4161 8) Anta et al. (2016), PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes; Cell Death Dis. 7 e2311

PROSTAGLANDIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROSTAGLANDIN A1 manufacturers

Sinoway Industrial co., ltd.
Product
Prostagladin E1 14152-28-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-07-28
Career Henan Chemical Co
Product
PROSTAGLANDIN A1 14152-28-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-19

14152-28-4, PROSTAGLANDIN A1Related Search:

PROSTAGLANDIN B1 Prostaglandin F2a PROSTAGLANDIN B2 PROSTAGLANDIN A2 PROSTAGLANDIN B1 15(S)-15-Methyl prostaglandin Undecenoic acid 10TR-PENTADECENOIC ACID PROSTAGLANDIN A1 2-Pentyn-1-ol 9BETA, 11ALPHA-PROSTAGLANDIN F2 PROSTAGLANDIN G2 Latanoprost PROSTAGLANDIN H1 Latanoprost acid ENPROSTIL PROSTAGLANDIN J2 Inositol

  • prostaglandina(sup1)
  • prostaglandine(sup1)-217
  • prostaglandina1syntheticcrystalline
  • (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
  • (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate
  • C04685
  • ProstaglandinA1,(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
  • Prostaglandin A1 (25 mg)
  • Prostaglandin Impurity A
  • PGA1 (Prostaglandin A1)
  • Prostaglandin A
  • prostaglandins A1 synthetic
  • 9-OXO-15S-HYDROXY-PROSTA-10,13E-DIEN-1-OIC ACID
  • [13E,15S]-15-HYDROXY 9-OXOPROSTA-10,13-DIEN-1-OIC ACID
  • PROSTAGLANDINS A1
  • PROSTAGLANDIN A1
  • PGA1
  • 13-dien-1-oicacid,15-hydroxy-9-oxo-,(13e,15s)-prosta-1
  • 2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentene-1-heptanoicaci
  • pga(sub1)
  • pga(sup1)
  • prostaglandina(sub1)
  • Prostagladin A
  • Alprostadil (Prostaglandin E1) EP Impurity A
  • Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
  • Prostagladin E1
  • Prostaglandin A1 (1578500)
  • a.7-[(1R,2S)-2-[(1e,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-enyl]heptanoicacid(prostaglandina1)
  • Prostaglandin (Alprostadil) EP Impurity A
  • 14152-28-4
  • 33647
  • BioChemical
  • Biochemicals and Reagents
  • Fatty Acids
  • Prostaglandins
  • Lipids