ChemicalBook > CAS DataBase List > PROSTAGLANDIN A1

PROSTAGLANDIN A1

Product Name: PROSTAGLANDIN A1
CAS No.: 14152-28-4
Chemical Name: PROSTAGLANDIN A1
Synonyms: PGA1;Prostaglandin A;Prostagladin E1;C04685;pga(sub1);pga(sup1);Prostagladin A;PROSTAGLANDIN A1;PROSTAGLANDINS A1;prostaglandina(sup1)
CBNumber: CB3666883
Molecular Formula: C20H32O4
Formula Weight: 336.47
MOL File: 14152-28-4.mol

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PROSTAGLANDIN A1 Property

Melting point:: 43°C
Boiling point:: 392.93°C (rough estimate)
Density: 1.0192 (rough estimate)
refractive index: 1.4434 (estimate)
storage temp.: -20°C
solubility: acetone: 10 mg/mL, clear
form: White solid.
pka: 4.77±0.10(Predicted)
color: Off-white
biological source: synthetic
BRN: 2003401
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: GY5977900
F: 8-10
HS Code: 2937500000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7265
Product name: Prostaglandin A1
Purity: synthetic
Packaging: 1mg
Price: $166
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1578500
Product name: Prostaglandin A1
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $3080
Updated: 2025/07/31

Cayman Chemical

Product number: 10010
Product name: Prostaglandin A1
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 10010
Product name: Prostaglandin A1
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: P7265
Product name: Prostaglandin A1
Purity: synthetic
Packaging: 5mg
Price: $546.25
Updated: 2025/07/31

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PROSTAGLANDIN A1 Chemical Properties,Usage,Production

Description

Prostaglandin A₁ (PGA₁) was first isolated as a dehydration product of the PGE₁ compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC₅₀ value for the inhibition of human ovarian cancer is 7.5 μM.

Uses

Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.

Definition

ChEBI: Prostaglandin A1 is a prostaglandins A. It is a conjugate acid of a prostaglandin A1(1-).

General Description

Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).

Biochem/physiol Actions

Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients.

Enzyme inhibitor

This eicosanoid (FWfree-acid = 336.47 g/mol; CAS 14152-28-4; Symbol: PGA1) induces apoptosis and stimulates the expression of stress genes. The structure and role of the prostaglandin A1 was investigated by Bergstr?m and Samuelsson, who shared the 1982 Nobel Prize in Physiology or Medicine for their pioneering work on the eicosanoids. Target(s): CYP4F2; DNA topoisomerase II; HIV-1 transcription; 3ahydroxysteroid dehydrogenase, NADP+-dependent; IkB kinase; Mayaro virus replication; stress-induced NF-kB activation; and virus protein biosynthesis, or translation.

References

[1] SANDRA J. LEE . Renal effects of prostaglandin A1 in patients with essential hypertension[J]. Kidney international, 1972, 1 4: Pages 254-262. DOI:10.1038/ki.1972.35
[2] MOKHTAR K. TOPPOZADA MD. Treatment of preeclampsia with prostaglandin A1[J]. American journal of obstetrics and gynecology, 1988, 159 1: Pages 160-165. DOI:10.1016/0002-9378(88)90514-5
[3] ANTONIO ROSSI. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase[J]. Nature, 2000, 403 6765: 103-108. DOI:10.1038/47520
[4] ASIM K MANDAL. Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation.[J]. Journal of immunology, 2005, 175 10: 6271-6273. DOI:10.4049/jimmunol.175.10.6271
[5] STEFANIA CARTA . Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-κB activity[J]. Prostaglandins, leukotrienes, and essential fatty acids, 2014, 91 6: Pages 311-323. DOI:10.1016/j.plefa.2014.07.009
[6] ATSUKO TSUKIMOTO . A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors[J]. Antiviral research, 2015, 117: Pages 1-9. DOI:10.1016/j.antiviral.2015.01.013
[7] BEATRIZ DÍEZ-DACAL. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.[J]. Cancer research, 2011: 4161-4171. DOI:10.1158/0008-5472.can-10-3816
[8] B ANTA. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes[J]. Cell Death & Disease, 2016, 7 7: e2311-e2311. DOI:10.1038/cddis.2016.219

PROSTAGLANDIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROSTAGLANDIN A1 Suppliers

China 74 Germany 2 India 4 Japan 1 South Korea 1 Switzerland 2 United Kingdom 4 United States 12 Global 100

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View Lastest Price from PROSTAGLANDIN A1 manufacturers

Sinoway Industrial co., ltd.

Product: Prostagladin E1 14152-28-4
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2021-07-28

Career Henan Chemical Co

Product: PROSTAGLANDIN A1 14152-28-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-19

14152-28-4, PROSTAGLANDIN A1Related Search:

PROSTAGLANDIN B1 Prostaglandin F2a PROSTAGLANDIN B2 PROSTAGLANDIN A2 PROSTAGLANDIN B1 15(S)-15-Methyl prostaglandin Undecenoic acid 10TR-PENTADECENOIC ACID PROSTAGLANDIN A1 2-Pentyn-1-ol 9BETA, 11ALPHA-PROSTAGLANDIN F2 PROSTAGLANDIN G2 Latanoprost PROSTAGLANDIN H1 Latanoprost acid ENPROSTIL PROSTAGLANDIN J2 Inositol

prostaglandina(sup1)

prostaglandine(sup1)-217

prostaglandina1syntheticcrystalline

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate

C04685

ProstaglandinA1,(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1

Prostaglandin A1 (25 mg)

Prostaglandin Impurity A

PGA1 (Prostaglandin A1)

Prostaglandin A

prostaglandins A1 synthetic

9-OXO-15S-HYDROXY-PROSTA-10,13E-DIEN-1-OIC ACID

[13E,15S]-15-HYDROXY 9-OXOPROSTA-10,13-DIEN-1-OIC ACID

PROSTAGLANDINS A1

PROSTAGLANDIN A1

PGA1

13-dien-1-oicacid,15-hydroxy-9-oxo-,(13e,15s)-prosta-1

2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentene-1-heptanoicaci

pga(sub1)

pga(sup1)

prostaglandina(sub1)

Prostagladin A

Alprostadil (Prostaglandin E1) EP Impurity A

Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-

Prostagladin E1

Prostaglandin A1 (1578500)

a.7-[(1R,2S)-2-[(1e,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-enyl]heptanoicacid(prostaglandina1)

Prostaglandin (Alprostadil) EP Impurity A

Prostaglandin A<sub>1</sub>

14152-28-4

33647

BioChemical

Biochemicals and Reagents

Fatty Acids

Prostaglandins

Lipids