ChemicalBook > CAS DataBase List > (D-Ala2)-Leu-Enkephalin

(D-Ala2)-Leu-Enkephalin

Product Name: (D-Ala2)-Leu-Enkephalin
CAS No.: 64963-01-5
Chemical Name: (D-Ala2)-Leu-Enkephalin
Synonyms: (D-ALA2)-LEU-ENKEPHALIN;TYR-D-ALA-GLY-PHE-LEU;D-ALA2-LEU5-ENKEPHALIN;(D-Ala)-Leu-Enkephalin;Pentapeptide-18 Peptide;Tyr-D-Ala-Gly-Phe-Leu-OH;Pentapeptide-3/Leuphasyl;H-TYR-D-ALA-GLY-PHE-LEU-OH;Leuphasyl / Pentapeptide-3;[D-ALA2]-LEUCINE ENKEPHALIN
CBNumber: CB3667734
Molecular Formula: C29H39N5O7
Formula Weight: 569.65
MOL File: 64963-01-5.mol

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(D-Ala2)-Leu-Enkephalin Property

Melting point:: 160-163.5 °C
Boiling point:: 991.9±65.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMF (Slightly), DMSO (Slightly)
pka: 3.40±0.10(Predicted)
form: Solid
color: White to Off-White
Sequence: Tyr-{d-Ala}-Gly-Phe-Leu
InChI: InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24+/m1/s1
InChIKey: ZHUJMSMQIPIPTF-JMBSJVKXSA-N
SMILES: C(O)(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E5008
Product name: [D-Ala2]-Leucine enkephalin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2025/07/31

ChemScene

Product number: CS-5905
Product name: [D-Ala2]-Leucine enkephalin
Purity: 99.77%
Packaging: 10mg
Price: $108
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA108766
Product name: (D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH
Packaging: 25mg
Price: $181
Updated: 2021/12/16

ChemScene

Product number: CS-5905
Product name: [D-Ala2]-Leucine enkephalin
Purity: 99.77%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

Activate Scientific

Product number: AS112962
Product name: [D-Ala2]-Leucine enkephalin
Purity: 97%
Packaging: 25mg
Price: $424
Updated: 2021/12/16

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(D-Ala2)-Leu-Enkephalin Chemical Properties,Usage,Production

Uses

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

Definition

The leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu, Leu-enk) is a natural endogenous ligand for opiate receptors. Leu-enk is rapidly metabolized in vivo and in vitro[1]. (D-Ala2)-Leu-Enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

benefits

(D-Ala2)-Leu-Enkephalin is widely distributed in the human body and has essential physiological functions. It has a unique effect on brain cells and can activate sleeping brain cells and have a good recovery effect on the sequelae caused by brain damage. It plays an important role in immune function, including increasing the activity of the immune system, T lymphocytes, NK cells, macrophages, antiviral, and the release of gamma interferon. It can participate in immune regulation by promoting the secretion of endocrine cells by activated immune cells, thereby affecting DNA's gene regulation and expression functions.

IC 50

δ Opioid Receptor/DOR

References

[1] H. Hasegawa, S. Baba, Y. Shinohara. “Synthesis of [D-Ala2]Leu-enkephalin and [D-Ala2, D-Leu5]Leu-enkephalin with high specific tritiated activity in the leucine residue.” Journal of The Chemical Society-perkin Transactions 1 12 1 (1990): 2641–2644.

(D-Ala2)-Leu-Enkephalin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (D-Ala2)-Leu-Enkephalin manufacturers

Xi an Biohorlden Industry Trade Co Ltd

Product: Pentapeptide-18 64963-01-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1kg
Release date: 2025-06-17

Chongqing Soarwin Technology Co., Ltd

Product: Pentapeptide-18 64963-01-5
Price: US $0.00-0.00/Box
Min. Order: 1Box
Purity: 99.99%
Supply Ability: 10 Boxes
Release date: 2025-06-10

Hebei Chuanghai Biotechnology Co., Ltd

Product: TYR-D-ALA-GLY-PHE-LEU 64963-01-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

64963-01-5, (D-Ala2)-Leu-EnkephalinRelated Search:

PALMITOYL TETRAPEPTIDE-3 Palmitoyl Pentapeptide Palmitoyl Tripeptide-5 Acetyl Tetrapeptide-5 NONAPEPTIDE-1 Acetyl Octapeptide-3 PALMITOYL TRIPEPTIDE-1 Lipopeptide Acetate Palmitoyl Pentapeptide-3 Matrixyl，PALMITOYL PENTAPEPTIDE-3 TYR-D-ALA-GLY-PHE-MET ACOH H2O Hexapeptide 9 HEXAPEPTIDE-3 Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Pentapeptide-25 Aprotinin TYR-D-ALA-GLY-PHE-LEU H-TYR-D-ALA-GLY-PHE-LEU-ARG-ARG-ILE-ARG-OH

H-TYR-D-ALA-GLY-PHE-LEU-OH

(D-ALA2)-LEU-ENKEPHALIN

D-ALA2-LEU5-ENKEPHALIN

[D-ALA2]-LEUCINE ENKEPHALIN

TYR-D-ALA-GLY-PHE-LEU

N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine

(D-alanine2)leucine enkephalin

L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH

(D-Ala2)-Leu-Enkephalin H-Tyr-D-Ala-Gly-Phe-Leu-OH

(D-Ala)-Leu-Enkephalin

[D-ALA2]LEUCINE-ENKEPHALIN, >99%

[D-Ala2]leucine-enkephalin,Tyr-D-Ala-Gly-Phe-Leu, >99%

Tyr-D-Ala-Gly-Phe-Leu-OH

2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid

2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-valeric acid

2-[[2-[2-[2-[[2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid

[D-Ala2]-Leucine enkephalin,Tyr-D-Ala-Gly-Phe-Leu

Pentapeptide-3/Leuphasyl

L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine

Tyrosyl-D-alanylglycylphenylalanylleucine

Leuphasyl / Pentapeptide-3

Leuphasyl / Pentapeptide-18

Pentapeptide-18/Leuphasyl with reduce facial muscle

L-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-

2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoicaci

TYR-D-ALA-GLY-PHE-LEU USP/EP/BP

Lab Supply High Purity Pentapeptide-18 Powder CAS 64963-01-5 with Best Price

Pentapeptide-18 Peptide

64963-01-5

C29H39N5O7

Enkephalins

Opioid Peptides

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Biochemicals and Reagents

Amino Acids and Peptides

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