1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Uses- Product Name
- 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
- CAS No.
- 5952-92-1
- Chemical Name
- 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
- Synonyms
- AKOS B000227;AKOS PAO-0317;TIMTEC-BB SBB000052;IFLAB-BB F2124-0619;ART-CHEM-BB B000227;ASINEX-REAG BAS 10145669;4-Carboxy-1-methyl-1H-pyrazole;1-methyl-4-pyrazolecarboxylic acid;1-methylpyrazole-4-carboxylic acid;1-Bethylpyrazole-4-carboxylic acid
- CBNumber
- CB3696004
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 5952-92-1.mol
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Property
- Melting point:
- 203-208°C
- Boiling point:
- 306.9±15.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.88±0.10(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to pale yellow
- InChI
- InChI=1S/C5H6N2O2/c1-7-3-4(2-6-7)5(8)9/h2-3H,1H3,(H,8,9)
- InChIKey
- UPPPWUOZCSMDTR-UHFFFAOYSA-N
- SMILES
- N1(C)C=C(C(O)=O)C=N1
- CAS DataBase Reference
- 5952-92-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 682063
- Product name
- 1-Methyl-1H-pyrazole-4-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $292
- Updated
- 2023/06/20
- Product number
- M2224
- Product name
- 1-Methylpyrazole-4-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- M2224
- Product name
- 1-Methylpyrazole-4-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $337
- Updated
- 2025/07/31
- Product number
- M320910
- Product name
- 1-Methyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 028252
- Product name
- 1-Methyl-1H-pyrazole-4-carboxylic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $69
- Updated
- 2021/12/16
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
1-Methylpyrazol-4-carboxylic acid is an organic intermediate that can be used to prepare an amide-substituted xanthine derivative, 1-methyl-1H-pyrazol-4-carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluoro-benzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-methyl-amide, which has gluconeogenesis-regulating activity.
Definition
ChEBI: 1-methyl-pyrazole-4-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group at position 4. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.
Synthesis
85290-80-8
5952-92-1
General procedure for the synthesis of 1-methyl-1H-pyrazole-4-carboxylic acid from ethyl 1-methyl-1H-pyrazole-4-carboxylate: 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (20.2 g, 131 mmol) and sodium hydroxide (6.3 g, 158 mmol) were dissolved in 200 mL of anhydrous ethanol and heated to reflux for 2 h. The stirring process was continued at room temperature for the subsequent 18 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water and the aqueous solution was washed with ether and subsequently acidified with concentrated hydrochloric acid. The precipitated solid was collected, filtered, washed with water and dried in air to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.
References
[1] Patent: US5498630, 1996, A
[2] Patent: US2004/14766, 2004, A1
[3] Patent: US2004/14766, 2004, A1
[4] Patent: WO2003/106459, 2003, A1. Location in patent: Page 116; 156
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Suppliers
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- info@pschemicals.com
- Country
- The Netherlands
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View Lastest Price from 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers
- Product
- 1-Methyl-1H-Pyrazole-4-Carboxylic Acid 5952-92-1
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 1-Methyl-1h-Pyrazole-4-Carboxylic Acid 5952-92-1
- Price
- US $200.00-95.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-22
- Product
- 1-Methyl-1H-pyrazole-4-carboxylic acid 5952-92-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10