Afloqualone

ChemicalBook > CAS DataBase List > Afloqualone

Product Name: Afloqualone
CAS No.: 56287-74-2
Chemical Name: Afloqualone
Synonyms: H-495;aroft;HQ-495;HQ 495;arofuto;Aoqualone;AFLOQUALONE;Afloquanone;Afloqualone D7;Afloqualone USP/EP/BP
CBNumber: CB3699964
Molecular Formula: C16H14FN3O
Formula Weight: 283.3
MOL File: 56287-74-2.mol

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Afloqualone Property

Melting point:: 195-196°C
Boiling point:: 492.5±55.0 °C(Predicted)
Density: 1.2529 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.73±0.70(Predicted)
color: White to Off-White
InChI: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
InChIKey: VDOSWXIDETXFET-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(N)C=C2)C(=O)N(C2=CC=CC=C2C)C=1CF
CAS DataBase Reference: 56287-74-2(CAS DataBase Reference)

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Safety

Toxicity: LD50 in mice (mg/kg): 315.1 i.p. (Tani)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21834
Product name: Afloqualone
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21834
Product name: Afloqualone
Purity: ≥98%
Packaging: 5mg
Price: $355
Updated: 2024/03/01

TRC

Product number: A357700
Product name: Afloqualone
Packaging: 1g
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-5009
Product name: Afloqualone
Purity: >98.0%
Packaging: 100mg
Price: $72
Updated: 2021/12/16

Matrix Scientific

Product number: 143959
Product name: 6-Amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3H)-one
Purity: 95%
Packaging: 1g
Price: $800
Updated: 2021/12/16

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Afloqualone Chemical Properties,Usage,Production

Description

Afloqualone is a centrally acting muscle relaxant useful in the management of various spastic conditions, including cerebral palsy, cervical spondylosis, and multiple sclerosis. It is closely related to the hypnotidsedative methaqualone.

Description

Afloqualone (Item No. 21834) is an analytical reference standard categorized as a quinazolinone. This product is intended for research and forensic applications.

Originator

Tanabe (Japan)

Uses

Afloqualone acts as a muscle relaxant in humans and may be used in the treatment of muscle spasms affecting rheumatoid arthritis.

Definition

ChEBI: Afloqualone is an organic molecular entity.

Manufacturing Process

14.4 g (0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g (0.08 mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g (0.126 mol) of fluoroacetyl chloride are added to the solution for 10 minutes under ice-cooling. The solution is stirred at the same temperature for 30 minutes and then at room temperature for 2.5 hours. The reaction solution is allowed to stand at room temperature overnight. The crystalline precipitate is collected by filtration, washed with water and then dried. 16.4 g of N-(2- fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained. Yield: 93.7%; MP 238-239°C.
16.5 g (0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and 25.5 g (0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial acetic acid. The solution is refluxed for 2 hours under heating. Then, the reaction solution is evaporated to remove solvent. The residue thus obtained is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with potassium carbonate. The crystalline precipitate is collected by filtration. 15.5 g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained. Yield: 98.7%; MP 155-158°C (recrystallized from ethanol).
A mixture of 2.0 g (0.064 mol) of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)- quinazolinone, 0.2 g of 5% palladium-carbon and 100 ml of acetic acid is shaken for 30 minutes in hydrogen gas. The initial pressure of hydrogen gas is adjusted to 46 lb and the mixture is heated with an infrared lamp during the reaction. After 30 minutes of this reaction, the pressure of hydrogen gas decreases to 6 lb. After the mixture is cooled, the mixture is filtered to remove the catalyst. The filtrate is evaporated to remove acetic acid, and the residue is dissolved in chloroform. The chloroform solution is washed with 5% aqueous sodium hydroxide and water, successively. Then, the solution is dried and evaporated to remove solvent. The oily residue thus obtained is dissolved in 2 ml of chloroform, and the chloroform solution is passed through a column of 200 g of silica gel. The silica gel column is eluted with ethyl acetatebenzene (1:1). Then, the eluate is evaporated to remove solvent. The crude crystal obtained is washed with isopropyl ether and recrystallized from isopropanol. 0.95 g of 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3H)-quinazolinone is obtained. Yield: 52.5%; MP 195-196°C.

brand name

AROFUTO

Therapeutic Function

Muscle relaxant

Afloqualone Preparation Products And Raw materials

Raw materials

Preparation Products

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Afloqualone Suppliers

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View Lastest Price from Afloqualone manufacturers

Dideu Industries Group Limited

Product: Afloqualone 56287-74-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-07

Career Henan Chemical Co

Product: Afloqualone 56287-74-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

56287-74-2, AfloqualoneRelated Search:

Aminopyrine Flumequine Sodium 2-Quinolinol Flumequine ALTRENOGEST 6-Aminocaproic acid Glycine Gliquidone Glucosamine DBU Quinocetone Tris(hydroxymethyl)aminomethane Acetaminophen Quinacridone 2-Quinoxalinone EC 2.6.1.2 6-AMINO-3H-QUINAZOLIN-4-ONE METHAQUALONE

Afloqualone 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-quinazolin-4-one

6-Amino-2-fluoromethyl-3-(o-tolyl)-quinazolin-4(3H)-one

H-495

HQ 495

HQ-495

Afloquanone

6-aMino-2-fluoroMethyl-3-(o-tolyl)-4(3h)-quinaz...

6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3h)-quinazolinon

6-amino-2-fluoromethyl-3-(o-tolyl)-4(3h)-quinazolinon

6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-quinazolin-4-one

AFLOQUALONE

6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4-quinazolinone

Aoqualone

6-amino-2-fluoromethyl-3-(o-tolyl)-4(3h)-quinazolinone

aroft

arofuto

6-Amino-2-Fluoromethyl-3-(2-Tolyl)-3H-quinazolin-4-one

4(3H)-Quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-

6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one

Afloqualone USP/EP/BP

Afloqualone D7

Dibenzofuran Impurity 2

56287-74-2

6287-74-2

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