4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE

Product Name: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE
CAS No.: 175137-21-0
Chemical Name: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE
Synonyms: BUTTPARK 46\18-89;4-Chloro-7-Methylthieno[3...;7-CHLORO-3-METHYLTHIENO(3,2-D)PYRIMIDINE;4-Chloro-7-methylthieno[2,3-d]pyrimidine;4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE;Thieno[3,2-d]pyrimidine,4-chloro-7-methyl-;4-Chloro-7-methylthieno[3,2-d]pyrimidine97%;4-Chloro-7-methylthieno[3,2-d]pyrimidine 97%;4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB3701869
Molecular Formula: C7H5ClN2S
Formula Weight: 184.65
MOL File: 175137-21-0.mol

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4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE Property

Melting point:: 124 °C
Boiling point:: 301.3±37.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.78±0.40(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C7H5ClN2S/c1-4-2-11-6-5(4)9-3-10-7(6)8/h2-3H,1H3
InChIKey: IYJDOVYAFDVIDB-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C2SC=C(C)C2=N1

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368488
Product name: 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 084152
Product name: 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Purity: 97%
Packaging: 5g
Price: $104
Updated: 2021/12/16

Matrix Scientific

Product number: 084152
Product name: 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Purity: 97%
Packaging: 1g
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-X6
Product name: 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Purity: 97%
Packaging: 250mg
Price: $49
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-X6
Product name: 4-Chloro-7-methylthieno[3,2-d]pyrimidine
Purity: 97%
Packaging: 1g
Price: $160
Updated: 2021/12/16

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4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

175137-13-0

175137-21-0

General procedure for the synthesis of 4-chloro-7-methylthieno[3,2-d]pyrimidin-4(1H)-one from 7-methylthieno[3,2-d]pyrimidin-4-one: 7-methyl-3H-thieno[3,2-d]pyrimidin-4-one (167, 10.6 g, 64.0 mmol) was dissolved in phosphorus nitrogen oxide (42 mL), and the reaction was carried out for 2 h under nitrogen protection at reflux. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into saturated aqueous sodium carbonate solution (300 mL) for neutralization. Subsequently, the aqueous phase was extracted with ethyl acetate, and the organic layers were combined, washed with water and saturated brine sequentially, and then dried with anhydrous magnesium sulfate. The organic solvent was removed by concentration under reduced pressure and the resulting residue was dried under vacuum overnight in the presence of phosphorus pentoxide to afford the white solid product 4-chloro-7-methylthieno[3,2-d]pyrimidine (168, 11.2 g, 95% yield).

References

[1] Patent: US2006/4002, 2006, A1. Location in patent: Page/Page column 12; 21; 23; 30; 31-32
[2] Patent: WO2013/100632, 2013, A1. Location in patent: Page/Page column 62
[3] Patent: US2014/371219, 2014, A1. Location in patent: Paragraph 0436; 0437
[4] Patent: WO2012/156756, 2012, A2. Location in patent: Page/Page column 99
[5] Patent: WO2011/93684, 2011, A2. Location in patent: Page/Page column 33; 34

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Sodium hydride Acetonitrile Acetic anhydride Ammonium formate Methyl 3-mercaptopropionate Formic acid Phosphorus oxitrichloride Hydroxylamine hydrochloride Methyl methacrylate 1,2-Dimethoxyethane Sodium carbonate Formamide

Preparation Products

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4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE Suppliers

Belgium 1 China 81 Germany 1 India 4 United Kingdom 5 United States 11 Global 103

Apollo Scientific Ltd.

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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
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MOLEKULA Ltd.

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Country: United Kingdom
ProdList: 6140
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Fluorochem Ltd

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Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Fluorochem Ltd.

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Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

Butt Park Ltd.

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Email: 113707.50@compuserve.com
Country: United Kingdom
ProdList: 6078
Advantage: 30

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View Lastest Price from 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 175137-21-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 175137-21-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

175137-21-0, 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINERelated Search:

Dichloromethane 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE 4-Chloro-5-methylthieno[2,3-d]pyrimidine ,97%,4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE 2-chloro-5-methylthieno[2,3-d]pyrimidine 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine 4-CHLORO-7-(4-CHLOROPHENYL)THIENO[3,2-D]PYRIMIDINE 4-CHLORO-7-PHENYL-THIENO[3,2-D]PYRIMIDINE 4-chloro-2-methylthieno[3,2-d]pyrimidine 4-CHLORO-7-(4-METHOXY-PHENYL)-THIENO[3,2-D]-PYRIMIDINE ETHYL 2-([(4-BROMOPHENYL)THIO]METHYL)-4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE METHYL 2-BENZYL-4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE 4-CHLORO-7-(4-ETHOXYPHENYL)THIENO[3,2-D]PYRIMIDINE 4-CHLORO-7-(4-FLUOROPHENYL)-THIENO[3,2-D] PYRIMIDINE 7-(4-BROMOPHENYL)-4-CHLOROTHIENO[3,2-D]PYRIMIDINE 4-CHLORO-7-(4-NITROPHENYL)THIENO[3,2-D]PYRIMIDINE

4-Chloro-7-methylthieno[3,2-d]pyrimidine 97%

4-Chloro-7-Methylthieno[3...

4-Chloro-7-methylthieno[3,2-d]pyrimidine97%

BUTTPARK 46\18-89

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE

4-Chloro-7-methylthieno[2,3-d]pyrimidine

7-CHLORO-3-METHYLTHIENO(3,2-D)PYRIMIDINE

Thieno[3,2-d]pyrimidine,4-chloro-7-methyl-

4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE ISO 9001：2015 REACH

175137-21-0