6-Hydroxypicolinic acid

ChemicalBook > CAS DataBase List > 6-Hydroxypicolinic acid

6-Hydroxypicolinic acid

Product Name: 6-Hydroxypicolinic acid
CAS No.: 19621-92-2
Chemical Name: 6-Hydroxypicolinic acid
Synonyms: 6-oxo-1,6-dihydropyridine-2-carboxylic acid;6-HYDROXYPICOLINIC ACID;6-CARBOXY-2(1H)-PYRIDINONE;6-hydroxy-2-pyridylic acid;6-HYDROXYPICOLINIC ACID 97+%;6-CARBOXY-2-HYDROXY-PYRIDINE;6-Hydroxypyridine-2-carboxyL;6-Hydroxy-2-pyridinecarboxylic;6-HPA, 6-hydroxypicolinic acid;6-oxo-1H-pyridine-2-carboxylicaci
CBNumber: CB3712566
Molecular Formula: C6H5NO3
Formula Weight: 139.11
MOL File: 19621-92-2.mol

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6-Hydroxypicolinic acid Property

Melting point:: 270 °C (dec.) (lit.)
Boiling point:: 436.0±45.0 °C(Predicted)
Density: 1.451±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 3.29±0.20(Predicted)
form: Powder
color: Yellow to brown
BRN: 115842
InChIKey: VRCWSYYXUCKEED-UHFFFAOYSA-N
CAS DataBase Reference: 19621-92-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 384305
Product name: 6-Hydroxypyridine-2-carboxylic acid
Purity: 95%
Packaging: 5g
Price: $38.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 384305
Product name: 6-Hydroxypyridine-2-carboxylic acid
Purity: 95%
Packaging: 25g
Price: $98.5
Updated: 2024/03/01

TCI Chemical

Product number: H0876
Product name: 6-Hydroxy-2-pyridinecarboxylic Acid
Purity: >97.0%(T)
Packaging: 5g
Price: $63
Updated: 2024/03/01

TCI Chemical

Product number: H0876
Product name: 6-Hydroxy-2-pyridinecarboxylic Acid
Purity: >97.0%(T)
Packaging: 25g
Price: $189
Updated: 2024/03/01

Matrix Scientific

Product number: 012677
Product name: 6-Hydroxy-2-pyridinecarboxylic acid
Purity: 97%
Packaging: 100g
Price: $245
Updated: 2021/12/16

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6-Hydroxypicolinic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

6-Hydroxypyridine-2-carboxylic acid may be used in the preparation of ruthenium(II) complex, [RuH(CO)(6-OH-py-2-COO)(PPh₃)₂].

Definition

ChEBI: 6-Hydroxypicolinic acid is an aromatic carboxylic acid and a member of pyridines.

General Description

6-Hydroxypyridine-2-carboxylic acid (6HPA, 6-Hydroxypicolinic acid) is a picolinic acid derivative. It has been reported to exhibit enol-keto tautomerism. It is a chelating ligand exhibiting potential complexing ability (via N,O-chelation or N,O,O-chelation). Intramolecular proton transfer (IPT) in tautomeric forms of 6HPA has been investigated by density functional theory (DFT) calculations.

Synthesis

6-Hydroxypicolinic acid is prepared by the reaction of 2-Bromo-6-hydroxypyridine and Carbon Dioxide. The specific synthesis steps are as follows:
To a solution of 2-bromo-6-hydroxypyridine (0.76 g, 4.4 mmol,1.0 equiv.) in dry THF (20 mL) at 0 C was added a 2 M solution of -PrMgCl in THF (2.2 mL,4.4 mmol, 1.0 equiv.) during 5 min. The clear solution was stirred at that temperature for anadditional 5 min, and a 2.5 M solution of n-BuLi in hexanes (3.5 mL, 8.8 mmol, 2.0 equiv.) wasadded dropwise during 5min, while maintaining the temperature below 20 C. The resultingmixture was stirred at that temperature for 0.5 h, dry CO2 (0.20 g, 1.0 equiv.) was added to20 C. The resulting mixture was warmed to 20 C in 0.5 h and quenched with water (6 mL).After stirring the mixture below 20 C for 10 min, the phases were separated and the water phasewas extracted one additional time with ethyl acetate. The resulting suspension was allowed to reachroom temperature and fitered through a mbox0.5 1 cm pad of silica gel eluted with 10 mL of ethylacetate. The ?ltrate was concentrated and the residue was puri?ed by ash chromatography on silicagel (eluent: petroleum ether/ethyl acetate = 10:1) to afford product 3m as off-white solid, 0.56 g (yield: 93percent) , m.p.: 275–277 C. 1H-NMR (600 MHz, DMSO) 7.56 (dd, J = 8.9, 7.0 Hz, 1H), 6.97 (d, J = 6.8 Hz,1H), 6.65 (d, J = 9.0 Hz, 1H). 13C-NMR (151 MHz, DMSO) 163.28, 162.67, 140.51, 137.97, 123.88, 110.42.

6-Hydroxypicolinic acid Preparation Products And Raw materials

Raw materials

Acetic anhydride Hydrogen peroxide Methyl picolinate Acetic acid

Preparation Products

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View Lastest Price from 6-Hydroxypicolinic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 6-Hydroxypicolinic acid 19621-92-2
Price: US $100.00/kg
Min. Order: 25kg
Purity: 99.99%
Supply Ability: 200ton
Release date: 2023-08-08

Hebei Weibang Biotechnology Co., Ltd

Product: 6-Hydroxypicolinic acid 19621-92-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Shanghai Yongzeng Technology Co.,Ltd

Product: 6-Oxo-1,6-dihydropyridine-2-carboxylicacid 19621-92-2
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-09

19621-92-2, 6-Hydroxypicolinic acidRelated Search:

Quinolinic acid 3-Hydroxypyridine 2,6-Lutidine 2-Picolinic acid Chromium picolinate 2,5-PYRIDINEDICARBOXYLIC ACID 2-Bromo-5-nitropyridine 2-Chloro-3-hydroxypyridine tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Trolox 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 6-METHOXY-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID Citrazinic acid 2,6-DICHLORO-3-HYDROXYPYRIDINE-4-CARBOXYLIC ACID 2-Hydroxy-5-nitronicotinic acid 3-HYDROXYPICOLINIC ACID METHYL ESTER ETHYL 6-HYDROXYPYRIDINE-2-CARBOXYLATE

6-CARBOXY-2-HYDROXY-PYRIDINE

6-Hydroxypicolinic acid, 6-Hydroxypyridine-2-carboxylic acid

2-PYRIDINECARBOXYLIC ACID, 1,6-DIHYDRO-6-OXO

6-HYDROXYPICOLINIC ACID 97+%

2-CARBOXY-1,6-DIHYDRO-6-OXOPYRIDINE

6-Hydroxypyridine-2-carboxylicacid：6-Hydroxypicolinic Acid

6-HPA, 6-hydroxypicolinic acid

6-Hydroxypyridine-2-carboxylic acid,6-Hydroxypicolinic acid, 6-Hydroxypyridine-2-carboxylic acid

6-Hydroxy-2-pyridinecarboxylic

6-oxo-1H-pyridine-2-carboxylic acid

6-HYDROXYPYRIDINE-2-CARBOXYLIC ACID

19621-92-22-PYRIDINECARBOXYLIC ACID, 1,6-DIHYDRO-6-OXO-

6-CARBOXY-2(1H)-PYRIDINONE

6-oxo-1,6-dihydropyridine-2-carboxylic acid

6-Hydroxypyridine-2-carboxylic acid 95%

6-HYDROXYPICOLINIC ACID

6-HYDROXY-2-PYRIDINECARBOXYLIC ACID

2-Hydroxy-6-PyridineCarboxylicAcid

6-Hydroxypyridine-2-Carboxylic Acid 6-Hydroxy-2-Pyridine Carboxylic Acid

2-Hydroxypyridine-6-carboxylic acid

2-PYRIDINE-6-HYDROXYCARBOXYLICACID

6-hydroxy-2-pyidine carboxylic acid

6-Hydroxy-2-pyridinecarboxylicAcid&gt

6-Hydroxypyridine-2-carboxyL

6-oxo-1H-pyridine-2-carboxylicaci

6-hydroxy-2-pyridylic acid

6-Hydroxypicolinic acid ISO 9001：2015 REACH

6-Hydroxypicolinic acid, 6-Hydroxypyridine-2-carboxylic acid, 6-Hydroxypyridine-2-carboxylic acid, 6-CARBOXY-2-HYDROXY-PYRIDINE, 6-Hydroxypicolinic acid, 6-Hydroxypyridine-2-carboxylic acid, 2-hydroxy-6-picolinic acid, 6-oxo-1,6-dihydro-3-pyridinecarboxylic acid, 6-Hydroxy-2-pyridinecarboxylic Acid

19621-92-2

Building Blocks

CARBOXYLIC ACID

Heterocyclic Building Blocks

Pyridines

Heterocyclic Building Blocks

blocks

Carboxes

Pyridines

pyridine derivative

Acids and Derivatives

Heterocycles

Building Blocks

Chemical Synthesis

Pyridine

Organic acids

pharmacetical

Carboxylic Acids