6-Hydroxypicolinic acid
- Product Name
- 6-Hydroxypicolinic acid
- CAS No.
- 19621-92-2
- Chemical Name
- 6-Hydroxypicolinic acid
- Synonyms
- 6-oxo-1,6-dihydropyridine-2-carboxylic acid;6-HYDROXYPICOLINIC ACID;6-CARBOXY-2(1H)-PYRIDINONE;6-hydroxy-2-pyridylic acid;6-HYDROXYPICOLINIC ACID 97+%;6-CARBOXY-2-HYDROXY-PYRIDINE;6-Hydroxypyridine-2-carboxyL;6-Hydroxy-2-pyridinecarboxylic;6-HPA, 6-hydroxypicolinic acid;6-oxo-1H-pyridine-2-carboxylicaci
- CBNumber
- CB3712566
- Molecular Formula
- C6H5NO3
- Formula Weight
- 139.11
- MOL File
- 19621-92-2.mol
6-Hydroxypicolinic acid Property
- Melting point:
- 270 °C (dec.) (lit.)
- Boiling point:
- 436.0±45.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.29±0.20(Predicted)
- form
- Powder
- color
- Yellow to brown
- BRN
- 115842
- InChIKey
- VRCWSYYXUCKEED-UHFFFAOYSA-N
- CAS DataBase Reference
- 19621-92-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 384305
- Product name
- 6-Hydroxypyridine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $38.5
- Updated
- 2024/03/01
- Product number
- 384305
- Product name
- 6-Hydroxypyridine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 25g
- Price
- $98.5
- Updated
- 2024/03/01
- Product number
- H0876
- Product name
- 6-Hydroxy-2-pyridinecarboxylic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $63
- Updated
- 2024/03/01
- Product number
- H0876
- Product name
- 6-Hydroxy-2-pyridinecarboxylic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $189
- Updated
- 2024/03/01
- Product number
- 012677
- Product name
- 6-Hydroxy-2-pyridinecarboxylic acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $245
- Updated
- 2021/12/16
6-Hydroxypicolinic acid Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
6-Hydroxypyridine-2-carboxylic acid may be used in the preparation of ruthenium(II) complex, [RuH(CO)(6-OH-py-2-COO)(PPh3)2].
Definition
ChEBI: 6-Hydroxypicolinic acid is an aromatic carboxylic acid and a member of pyridines.
General Description
6-Hydroxypyridine-2-carboxylic acid (6HPA, 6-Hydroxypicolinic acid) is a picolinic acid derivative. It has been reported to exhibit enol-keto tautomerism. It is a chelating ligand exhibiting potential complexing ability (via N,O-chelation or N,O,O-chelation). Intramolecular proton transfer (IPT) in tautomeric forms of 6HPA has been investigated by density functional theory (DFT) calculations.
Synthesis
6-Hydroxypicolinic acid is prepared by the reaction of 2-Bromo-6-hydroxypyridine and Carbon Dioxide. The specific synthesis steps are as follows:
To a solution of 2-bromo-6-hydroxypyridine (0.76 g, 4.4 mmol,1.0 equiv.) in dry THF (20 mL) at 0 C was added a 2 M solution of -PrMgCl in THF (2.2 mL,4.4 mmol, 1.0 equiv.) during 5 min. The clear solution was stirred at that temperature for anadditional 5 min, and a 2.5 M solution of n-BuLi in hexanes (3.5 mL, 8.8 mmol, 2.0 equiv.) wasadded dropwise during 5min, while maintaining the temperature below 20 C. The resultingmixture was stirred at that temperature for 0.5 h, dry CO2 (0.20 g, 1.0 equiv.) was added to20 C. The resulting mixture was warmed to 20 C in 0.5 h and quenched with water (6 mL).After stirring the mixture below 20 C for 10 min, the phases were separated and the water phasewas extracted one additional time with ethyl acetate. The resulting suspension was allowed to reachroom temperature and fitered through a mbox0.5 1 cm pad of silica gel eluted with 10 mL of ethylacetate. The ?ltrate was concentrated and the residue was puri?ed by ash chromatography on silicagel (eluent: petroleum ether/ethyl acetate = 10:1) to afford product 3m as off-white solid, 0.56 g (yield: 93percent) , m.p.: 275–277 C. 1H-NMR (600 MHz, DMSO) 7.56 (dd, J = 8.9, 7.0 Hz, 1H), 6.97 (d, J = 6.8 Hz,1H), 6.65 (d, J = 9.0 Hz, 1H). 13C-NMR (151 MHz, DMSO) 163.28, 162.67, 140.51, 137.97, 123.88, 110.42.
6-Hydroxypicolinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Hydroxypicolinic acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 6-Hydroxypicolinic acid manufacturers
- Product
- 6-Hydroxypicolinic acid 19621-92-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 6-Oxo-1,6-dihydropyridine-2-carboxylicacid 19621-92-2
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-09
- Product
- 6-Hydroxypicolinic acid 19621-92-2
- Price
- US $100.00/kg
- Min. Order
- 25kg
- Purity
- 99.99%
- Supply Ability
- 200ton
- Release date
- 2023-08-08