ChemicalBook > CAS DataBase List > 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 57401-76-0
- Chemical Name
- 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- EOS-60351;NSC 165511;5-Carbethoxy-2-pyriMidinaMine;ETHYL 2-AMINO-5-PYRIMIDINECARBOXYLATE;2-Amino-5-pyrimidinecarboxylic acid ethyl ester;2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;5-PyriMidinecarboxylic acid, 2-aMino-, ethyl ester;2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB3721360
- Molecular Formula
- C7H9N3O2
- Formula Weight
- 167.17
- MOL File
- 57401-76-0.mol
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2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 147-149℃
- Boiling point:
- 349℃
- Density
- 1.261
- Flash point:
- 165℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 1.94±0.10(Predicted)
- Appearance
- White to light yellow Solid
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A617145
- Product name
- 2-Amino-pyrimidine-5-carboxylicAcidEthylEster
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
Usbiological
- Product number
- 415417
- Product name
- 2-Amino-pyrimidine-5-carboxylic Acid Ethyl Ester
- Packaging
- 100mg
- Price
- $312
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR912994
- Product name
- 2-Amino-pyrimidine-5-carboxylicacidethylester
- Purity
- 95%
- Packaging
- 5g
- Price
- $460
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR912994
- Product name
- 2-Amino-pyrimidine-5-carboxylicacidethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 076316
- Product name
- Ethyl 2-aminopyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $639
- Updated
- 2021/12/16
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2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
2-Amino-pyrimidine-5-carboxylic Acid Ethyl Ester is a reagent used in the synthesis of retinoidal pyrimidinecarboxylic acids.
Synthesis
148550-51-0
57401-76-0
The general procedure for the synthesis of ethyl 2-aminopyrimidine-5-carboxylate from ethyl 2-methylsulfonyl-5-pyrimidinecarboxylate was as follows: ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (2.15 g, 9.34 mmol) was dissolved in acetonitrile (11.7 mL) and stirred at room temperature. Subsequently, 32% aqueous ammonium hydroxide solution (11.36 mL, 93 mmol) was added slowly and dropwise. The reaction mixture transformed into a white suspension within seconds. The acetonitrile was removed by rotary evaporator and the remaining aqueous phase suspension was filtered through a Brinell funnel. The resulting solid was washed with distilled water (20 mL) and dried to give ethyl 2-aminopyrimidine-5-carboxylate as a white solid (1.192 g, 7.13 mmol, 76% yield, MS/ESI+ 168.1 [MH]+).
References
[1] Patent: US2013/79313, 2013, A1. Location in patent: Paragraph 1024
[2] Patent: WO2013/45280, 2013, A1. Location in patent: Page/Page column 276
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Sodium hydride
Ethyl formate
Propanoicacid,2-formyl-3-oxo-,ethylester
Sodium
Guanidine hydrochloride
Ethyl acetate
Ethyl 3,3-Diethoxypropionate
Preparation Products
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View Lastest Price from 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers
Dideu Industries Group Limited
- Product
- 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 57401-76-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-13
Career Henan Chemical Co
- Product
- 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 57401-76-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26
57401-76-0, 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTERRelated Search:
Ethyl 2-amino-1,3-thiazole-4-carboxylate
2-Aminotoluene-5-sulfonic acid
6-Aminopyridine-2-carboxylic acid
2-Aminopyrimidine-5-carboxylic acid
2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE
ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
ETHYL 2-AMINO-4-PROPYLPYRIMIDINE-5-CARBOXYLATE
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
ETHYL 2-MORPHOLINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
5-(4-CHLOROBENZYLOXYCARBONYL)-4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL HYDRAZINE
ETHYL 4-HYDROXY-2-(PIPERIDIN-1-YL)PYRIMIDINE-5-CARBOXYLATE
ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE
ETHYL 2-(2-[3-(CHLOROMETHYL)BENZOYL]HYDRAZINO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
BENZYL 2-HYDRAZINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
ETHYL 2,4-DIAMINO-6-METHYLPYRIMIDINE-5-CARBOXYLATE
ETHYL 2-HYDRAZINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
4-CHLOROBENZYL 2-[2-(2-CHLOROACETYL)HYDRAZINO]-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE