ChemicalBook > CAS DataBase List > 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Product Name
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
CAS No.
57401-76-0
Chemical Name
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
Synonyms
EOS-60351;NSC 165511;5-Carbethoxy-2-pyriMidinaMine;ETHYL 2-AMINO-5-PYRIMIDINECARBOXYLATE;2-Amino-5-pyrimidinecarboxylic acid ethyl ester;2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;5-PyriMidinecarboxylic acid, 2-aMino-, ethyl ester;2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
CBNumber
CB3721360
Molecular Formula
C7H9N3O2
Formula Weight
167.17
MOL File
57401-76-0.mol
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2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:
147-149℃
Boiling point:
349℃
Density 
1.261
Flash point:
165℃
storage temp. 
2-8°C(protect from light)
pka
1.94±0.10(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A617145
Product name
2-Amino-pyrimidine-5-carboxylicAcidEthylEster
Packaging
500mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
415417
Product name
2-Amino-pyrimidine-5-carboxylic Acid Ethyl Ester
Packaging
100mg
Price
$312
Updated
2021/12/16
Apolloscientific
Product number
OR912994
Product name
2-Amino-pyrimidine-5-carboxylicacidethylester
Purity
95%
Packaging
1g
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
076316
Product name
Ethyl 2-aminopyrimidine-5-carboxylate
Purity
95+%
Packaging
1g
Price
$221
Updated
2021/12/16
Apolloscientific
Product number
OR912994
Product name
2-Amino-pyrimidine-5-carboxylicacidethylester
Purity
95%
Packaging
5g
Price
$460
Updated
2021/12/16
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2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

2-Amino-pyrimidine-5-carboxylic Acid Ethyl Ester is a reagent used in the synthesis of retinoidal pyrimidinecarboxylic acids.

Synthesis

148550-51-0

57401-76-0

The general procedure for the synthesis of ethyl 2-aminopyrimidine-5-carboxylate from ethyl 2-methylsulfonyl-5-pyrimidinecarboxylate was as follows: ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (2.15 g, 9.34 mmol) was dissolved in acetonitrile (11.7 mL) and stirred at room temperature. Subsequently, 32% aqueous ammonium hydroxide solution (11.36 mL, 93 mmol) was added slowly and dropwise. The reaction mixture transformed into a white suspension within seconds. The acetonitrile was removed by rotary evaporator and the remaining aqueous phase suspension was filtered through a Brinell funnel. The resulting solid was washed with distilled water (20 mL) and dried to give ethyl 2-aminopyrimidine-5-carboxylate as a white solid (1.192 g, 7.13 mmol, 76% yield, MS/ESI+ 168.1 [MH]+).

References

[1] Patent: US2013/79313, 2013, A1. Location in patent: Paragraph 1024
[2] Patent: WO2013/45280, 2013, A1. Location in patent: Page/Page column 276

2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Sodium hydride Ethyl formate Propanoicacid,2-formyl-3-oxo-,ethylester Sodium Guanidine hydrochloride Ethyl acetate Ethyl 3,3-Diethoxypropionate

Preparation Products

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2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Suppliers

China 96 Germany 1 India 1 United Kingdom 1 United States 7 Global 106
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
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View Lastest Price from 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers

Dideu Industries Group Limited
Product
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 57401-76-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-13
Career Henan Chemical Co
Product
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 57401-76-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

57401-76-0, 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTERRelated Search:

Ethyl 2-amino-1,3-thiazole-4-carboxylate 2-Aminotoluene-5-sulfonic acid 6-Aminopyridine-2-carboxylic acid 2-Aminopyrimidine-5-carboxylic acid 2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-AMINO-4-PROPYLPYRIMIDINE-5-CARBOXYLATE 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-MORPHOLINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 5-(4-CHLOROBENZYLOXYCARBONYL)-4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL HYDRAZINE ETHYL 4-HYDROXY-2-(PIPERIDIN-1-YL)PYRIMIDINE-5-CARBOXYLATE ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE ETHYL 2-(2-[3-(CHLOROMETHYL)BENZOYL]HYDRAZINO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE BENZYL 2-HYDRAZINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2,4-DIAMINO-6-METHYLPYRIMIDINE-5-CARBOXYLATE ETHYL 2-HYDRAZINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLOROBENZYL 2-[2-(2-CHLOROACETYL)HYDRAZINO]-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

  • ETHYL 2-AMINO-5-PYRIMIDINECARBOXYLATE
  • 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
  • 5-Carbethoxy-2-pyriMidinaMine
  • 5-PyriMidinecarboxylic acid, 2-aMino-, ethyl ester
  • 2-Amino-5-pyrimidinecarboxylic acid ethyl ester
  • NSC 165511
  • EOS-60351
  • 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
  • 57401-76-0
  • Heterocycle-Pyrimidine series
  • pharmacetical
  • API intermediates