2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

Product Name: 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
CAS No.: 99754-06-0
Chemical Name: 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
Synonyms: ONO-RS-082;2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID;2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid;4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid;2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt;4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363);4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
CBNumber: CB3723445
Molecular Formula: C21H22ClNO3
Formula Weight: 371.86
MOL File: 99754-06-0.mol

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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Property

Melting point:: 175-177℃
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
form: powder
color: white
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2
HazardClass: 9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O0766
Product name: ONO-RS-082
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $122
Updated: 2024/03/01

Sigma-Aldrich

Product number: O0766
Product name: ONO-RS-082
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $475
Updated: 2024/03/01

Alfa Aesar

Product number: J67444
Product name: ONO-RS-082, 98%
Packaging: 20mg
Price: $141
Updated: 2023/06/20

Cayman Chemical

Product number: 20243
Product name: ONO-RS-082
Purity: ≥98%
Packaging: 100mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 20243
Product name: ONO-RS-082
Packaging: 25mg
Price: $130
Updated: 2024/03/01

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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Chemical Properties,Usage,Production

Description

ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5

Uses

ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor.

in vitro

previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].

References

1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197 2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361 3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530 4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004 5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Suppliers

China 34 Switzerland 1 United States 10 Global 45

Shanghai EFE Biological Technology Co., Ltd.

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Wuhan Yuxiang Medical Technology Co., Ltd.

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99754-06-0, 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACIDRelated Search:

Citicoline sodium U-73343 Phosphatidylinositol (Soy) SodiuM ARISTOLOCHIC ACID SODIUM SALT ISOTETRANDRINE 2-Heptadecanone OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE Thioetheramide PC UMBELLIFERYL ARACHIDONATE LUFFARIELLOLIDE 2-Amino-4-chlorobenzoic acid AKOS BBS-00007306 2-AMINO-4-CHLORO-BENZENEMETHANOL ACA 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID 2-(ACETYLAMINO)-4-CHLOROBENZOIC ACID 2-(p-amylcinnamoyl)-amino-4-chlorobenzoic acid (ONO-RS-082)

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

ONO-RS-082

2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid

2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt

4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid

(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363)

4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid

Benzoic acid, 4-chloro-2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-

4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid

lung,neutrophils,hepoxilin,ONO RS 082,prostaglandin,arachidonic,inhibit,inflammation,Phospholipase,Inhibitor,ONORS082,acid

4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid

99754-06-0