ChemicalBook > CAS DataBase List > Carbimazole

Carbimazole

Product Name
Carbimazole
CAS No.
22232-54-8
Chemical Name
Carbimazole
Synonyms
Carbimazol;Carbinazole;Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate;CG1;NUPL2;Tyrazol;Basolest;CARBIMAZOLE;Athyromazole;Neomercazole
CBNumber
CB3731303
Molecular Formula
C7H10N2O2S
Formula Weight
186.23
MOL File
22232-54-8.mol
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Carbimazole Property

Melting point:
124°C
Boiling point:
240.4±23.0 °C(Predicted)
Density 
1.2900 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
pka
-1.70±0.20(Predicted)
color 
white to beige
Water Solubility 
Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.
Sensitive 
Light Sensitive
Merck 
14,1798
BRN 
144339
InChIKey
CFOYWRHIYXMDOT-UHFFFAOYSA-N
CAS DataBase Reference
22232-54-8(CAS DataBase Reference)
NIST Chemistry Reference
Carbimazole(22232-54-8)
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Safety

Risk Statements 
22-36-43
Safety Statements 
22-36/37/39
RIDADR 
3335
WGK Germany 
3
RTECS 
NJ2441000
HS Code 
2933.29.9000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0931
Product name
Carbimazole
Purity
≥98% (HPLC)
Packaging
10mg
Price
$29.4
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1684
Product name
Carbimazole
Packaging
1g
Price
$214
Updated
2024/03/01
TCI Chemical
Product number
C1080
Product name
Carbimazole
Purity
>95.0%(HPLC)
Packaging
5g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
C1080
Product name
Carbimazole
Purity
>95.0%(HPLC)
Packaging
25g
Price
$195
Updated
2024/03/01
Alfa Aesar
Product number
L08218
Product name
Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97%
Packaging
25g
Price
$206.65
Updated
2024/03/01
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Carbimazole Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Carbimazol,Cid Co.

Uses

Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.

Uses

Thionamide antithyroid drug.

Uses

Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.

Definition

ChEBI: A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.

Manufacturing Process

0.1 mol of 1-methyl-2-mercaptoglyoxaline is dissolved in the minimum quantity of pyridine at 0°C 0.1 mol of ethyl chloroformate is added drop wise with stirring. More pyridine is added, if necessary, to keep the mixture semi-fluid. The sludge is then placed in an ice bath for 30 minutes. The crystals are filtered off and washed firstly with a little ethanol and secondly with ethanol and water. The non-basic desired ethyl 3-methyl-2-thioimidazoline-1- carboxylate is the colourless needles having a melting point of 122°-123°C.

Therapeutic Function

Thyroid inhibitor

Clinical Use

Treatment of hyperthyroidism

Synthesis

Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-1-carboxylic acid (25.2.7), is synthesized by a simultaneous reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7).

Veterinary Drugs and Treatments

Carbimazole (a pro-drug of methimazole) or methimazole are considered by most clinicians to be the agents of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole.
Methimazole and therefore, carbimazole, may be useful for the prophylactic prevention of cisplatin-induced nephrotoxicity in dogs.

Metabolism

Carbimazole is rapidly metabolised to thiamazole, which is concentrated in the thyroid gland. Over 90% of orally administered carbimazole is excreted in the urine as thiamazole or its metabolites. The remainder appears in faeces. There is 10% enterohepatic circulation. Thiamazole is metabolised, probably by the liver, and excreted in the urine. Less than 12% of a dose of thiamazole may be excreted as unchanged drug

Carbimazole Preparation Products And Raw materials

Raw materials

Methylamine Ethyl chloroformate 2-MERCAPTOIMIDAZOLE Chloroacetaldehyde diethyl acetal Potassium thiocyanate (2,2-diethoxyethyl)methylamine

Preparation Products

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Carbimazole Suppliers

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View Lastest Price from Carbimazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Carbimazole 22232-54-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min; BP
Supply Ability
500kg
Release date
2021-09-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
Carbimazole 22232-54-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Carbimazole 22232-54-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

22232-54-8, CarbimazoleRelated Search:

Thiophanate-methyl Bensulfuron methyl Methylparaben Imidazolidine RESMETHRIN Sodium thiosulfate Methyl acetate Thioacetamide Ethyl imidazole-4-carboxylate Methyl acrylate Kresoxim-methyl Imidazole Methyl Parathion-methyl Methyl bromide TRIMETHYLTHIOUREA DIMETHYLAMMONIUM DIMETHYLCARBAMATE(DIMCARB) noxytiolin

  • CARBIMAZOLE
  • ETHYL 3-METHYL-2-THIOMIDAZOLINE-1-CARBOXYLATE
  • ETHYL 3-METHYL-2-THIONOIMIDAZOLINE-1-CARBOXYLATE
  • LABOTEST-BB LT00455569
  • Ethyl 3-methyl-2-thioxo-4-imidazoline-1-carboxylate
  • 1-Methyl-2-imidazolethiol ethyl carbamate
  • 3-methyl-2-thionoimidazoline-1-carboxylic acid ethyl ester
  • 1-ETHOXYCARBONYL-3-METHYL-2-THIOXO-4-IMIDAZOLINE
  • 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester
  • O-ethylS-(1-methylimida-zol-2-yl)carbamate
  • Tyrazol
  • 1-Methyl-3-carbethoxy-2-thioglyoxalone
  • ethyl 3-Methyl-2-sulfanylidene-2,3-dihydro-1H-iMidazole-1-carboxylate
  • ANTI-NUPL2 (N-TERM) antibody produced in rabbit
  • Nucleoporin hCG1
  • Nucleoporin-like protein 2
  • NUP42 homolog
  • NUPL2
  • 1-Ethoxycarbonyl-3- Methyl-2-thio-4-iMidazoline
  • CARBIMAZOLE EP
  • 3-methyl-2-sulfanylidene-1-imidazolecarboxylic acid ethyl ester
  • 1h-imidazole-1-carboxylicacid,2,3-dihydro-3-methyl-2-thioxo,ethylester
  • 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylicacidethylester
  • 2-Carbethoxythio-1-methylimidazole
  • 3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester
  • 3-methyl-2-thioxo-4-imidazoline-1-carboxylicacidethylester
  • 3-methyl-2-thioxo-4-imidazoline-1-carboxylicaciethylester
  • 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester
  • Athyromazole
  • Basolest
  • Carbethoxymethimazole
  • Carbimazol
  • Carbinazole
  • CG1
  • Ethyl 3-methyl-2-thioimidazoline-1-carboxylate
  • Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
  • Neomercazole
  • Neo-thyreostat
  • Methyl-2-imidazol-thiol carbonate ethyl ester
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  • ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate
  • 22232-54-8
  • API
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