Torcetrapib
- Product Name
- Torcetrapib
- CAS No.
- 262352-17-0
- Chemical Name
- Torcetrapib
- Synonyms
- cp529;CS-156;CP 529414;Torcetropib;Torcetrapib;TORCETRAPIB-D3;Torcetrapib USP/EP/BP;Torcetrapib (CP-529414);(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
- CBNumber
- CB3739389
- Molecular Formula
- C26H25F9N2O4
- Formula Weight
- 600.47
- MOL File
- 262352-17-0.mol
Torcetrapib Property
- Melting point:
- 54-58°C
- Boiling point:
- 504.8±50.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- Store at RT
- solubility
- DMSO: >5mg/mL
- pka
- -1.87±0.40(Predicted)
- form
- powder
- color
- white
- optical activity
- [α]/D >-70°
- CAS DataBase Reference
- 262352-17-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- PZ0170
- Product name
- Torcetrapib
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- PZ0170
- Product name
- Torcetrapib
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 15028
- Product name
- Torcetrapib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 15028
- Product name
- Torcetrapib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 15028
- Product name
- Torcetrapib
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $577
- Updated
- 2024/03/01
Torcetrapib Chemical Properties,Usage,Production
Chemical Properties
Off-White Low Melting Solid
Uses
Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.
Definition
ChEBI: Torcetrapib is a member of quinolines, a carbamate ester and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.
Biological Activity
torcetrapib is a cetp inhibitor with ic50 of 37 nm, elevates hdl-c and reduces nonhdl-c in plasma. inhibition of cholesteryl ester transfer protein (cetp) has been shown to have a substantial effect on plasma lipoprotein levels.
in vitro
torcetrapib dose-dependently increases aldosterone release from h295r cells after either 24 or 48 h of treatment, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. torcetrapib (1 μm) significantly increases the expression of steroidogenic gene, cyp11b2 and cyp11b1, in h295r cell lines [1].
in vivo
researchers tested torcetrapib in rabbits fed an atherogenic diet at a dose sufficient to increase hdl-c by at least 3-fold. cetp activity was inhibited by 70–80% throughout the study. non-hdl-c increased in both groups, but there was no difference apparent by the study’s end [2].
storage
Room temperature
References
[1] hu x, dietz jd, xia c, knight dr, loging wt, smith ah, yuan h, perry da, keiser j. torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. endocrinology. 2009;150(5):2211-9.
[2] morehouse la, sugarman ed, bourassa pa, sand tm, zimetti f, gao f, rothblat gh, milici aj. inhibition of cetp activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in new zealand white rabbits. j lipid res. 2007;48(6):1263-72.
[3] barter pj, caulfield m, eriksson m, grundy sm, kastelein jj, komajda m, lopez-sendon j, mosca l, tardif jc, waters dd, shear cl, revkin jh, buhr ka, fisher mr, tall ar, brewer b; illuminate investigators. effects of torcetrapib in patients at high risk for coronary events. n engl j med. 2007;357(21):2109-22.
Torcetrapib Preparation Products And Raw materials
Raw materials
Preparation Products
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