ChemicalBook > CAS DataBase List > Torcetrapib

Torcetrapib

Product Name
Torcetrapib
CAS No.
262352-17-0
Chemical Name
Torcetrapib
Synonyms
cp529;CS-156;CP 529414;Torcetropib;Torcetrapib;TORCETRAPIB-D3;Torcetrapib USP/EP/BP;Torcetrapib (CP-529414);(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
CBNumber
CB3739389
Molecular Formula
C26H25F9N2O4
Formula Weight
600.47
MOL File
262352-17-0.mol
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Torcetrapib Property

Melting point:
54-58°C
Boiling point:
504.8±50.0 °C(Predicted)
Density 
1.42
storage temp. 
Store at RT
solubility 
DMSO: >5mg/mL
pka
-1.87±0.40(Predicted)
form 
powder
color 
white
optical activity
[α]/D >-70°
CAS DataBase Reference
262352-17-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0170
Product name
Torcetrapib
Purity
≥98% (HPLC)
Packaging
5mg
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0170
Product name
Torcetrapib
Purity
≥98% (HPLC)
Packaging
25mg
Price
$437
Updated
2024/03/01
Cayman Chemical
Product number
15028
Product name
Torcetrapib
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
15028
Product name
Torcetrapib
Purity
≥98%
Packaging
10mg
Price
$137
Updated
2024/03/01
Cayman Chemical
Product number
15028
Product name
Torcetrapib
Purity
≥98%
Packaging
50mg
Price
$577
Updated
2024/03/01
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Torcetrapib Chemical Properties,Usage,Production

Chemical Properties

Off-White Low Melting Solid

Uses

Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.

Definition

ChEBI: Torcetrapib is a member of quinolines, a carbamate ester and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.

Biological Activity

torcetrapib is a cetp inhibitor with ic50 of 37 nm, elevates hdl-c and reduces nonhdl-c in plasma. inhibition of cholesteryl ester transfer protein (cetp) has been shown to have a substantial effect on plasma lipoprotein levels.

in vitro

torcetrapib dose-dependently increases aldosterone release from h295r cells after either 24 or 48 h of treatment, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. torcetrapib (1 μm) significantly increases the expression of steroidogenic gene, cyp11b2 and cyp11b1, in h295r cell lines [1].

in vivo

researchers tested torcetrapib in rabbits fed an atherogenic diet at a dose sufficient to increase hdl-c by at least 3-fold. cetp activity was inhibited by 70–80% throughout the study. non-hdl-c increased in both groups, but there was no difference apparent by the study’s end [2].

storage

Room temperature

References

[1] hu x, dietz jd, xia c, knight dr, loging wt, smith ah, yuan h, perry da, keiser j. torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. endocrinology. 2009;150(5):2211-9.
[2] morehouse la, sugarman ed, bourassa pa, sand tm, zimetti f, gao f, rothblat gh, milici aj. inhibition of cetp activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in new zealand white rabbits. j lipid res. 2007;48(6):1263-72.
[3] barter pj, caulfield m, eriksson m, grundy sm, kastelein jj, komajda m, lopez-sendon j, mosca l, tardif jc, waters dd, shear cl, revkin jh, buhr ka, fisher mr, tall ar, brewer b; illuminate investigators. effects of torcetrapib in patients at high risk for coronary events. n engl j med. 2007;357(21):2109-22.

Torcetrapib Preparation Products And Raw materials

Raw materials

Preparation Products

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262352-17-0, TorcetrapibRelated Search:


  • CP 529414
  • (2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • Torcetrapib (CP-529414)
  • cp529
  • (2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • Torcetropib
  • CS-156
  • TORCETRAPIB-D3
  • (2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
  • (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylicacidethylester
  • Torcetrapib
  • 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
  • Torcetrapib USP/EP/BP
  • 262352-17-0
  • C26H25F9N2O4
  • Inhibitor
  • Aromatics
  • Chiral Reagents
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer compounds
  • Pharmaceuticals