2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER
- Product Name
- 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER
- CAS No.
- 197376-47-9
- Chemical Name
- 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-Chloropyridine-5-acetate;Ethyl 6-Chloropyridine-3-acetate;2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL;ETHYL (6-CHLOROPYRIDIN-3-YL)-ACETATE;Ethyl 2-(6-chloropyridin-3-yl)acetate;2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER;6-Chloro-3-pyridineacetic acid ethyl ester;3-Pyridineacetic acid, 6-chloro-, ethyl ester;2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB3758232
- Molecular Formula
- C9H10ClNO2
- Formula Weight
- 199.63
- MOL File
- 197376-47-9.mol
2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Property
- Boiling point:
- 285.8±25.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.34±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H10ClNO2/c1-2-13-9(12)5-7-3-4-8(10)11-6-7/h3-4,6H,2,5H2,1H3
- InChIKey
- HNMKCAOYIPYXRD-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC=C1CC(OCC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B126528
- Product name
- ethyl2-(6-chloropyridin-3-yl)acetate
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- J52123
- Product name
- 2-Chloropyridine-5-aceticacidethylester
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- J52123
- Product name
- 2-Chloropyridine-5-aceticacidethylester
- Packaging
- 10g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- HCH0319598
- Product name
- 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.15
- Updated
- 2021/12/16
- Product number
- A110060
- Product name
- Ethyl6-Chloropyridine-3-acetate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $27
- Updated
- 2021/12/16
2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
64-17-5
39891-13-9
197376-47-9
The general procedure for the synthesis of ethyl 2-(6-chloropyridin-3-yl)acetate from ethanol and 2-chloropyridine-5-acetic acid was as follows: to an ethanolic solution of 6-chloro-3-pyridineacetic acid (1 g, 5.83 mmol) was slowly added concentrated sulfuric acid (1.6 mL). The reaction mixture was heated to reflux and kept for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated in a rotary evaporator to remove most of the ethanol. The concentrated residue was dissolved in ethyl acetate and subsequently washed with saturated sodium bicarbonate solution to neutralize the residual acid. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by silica gel column chromatography to afford ethyl 2-(6-chloropyridin-3-yl)acetate (1.1 g, 95% yield).
References
[1] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 99
[2] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 147
[3] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0664
[4] Patent: US2013/29962, 2013, A1. Location in patent: Paragraph 0815
[5] Chemical Communications, 2015, vol. 51, # 84, p. 15446 - 15449
2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Suppliers
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View Lastest Price from 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER manufacturers
- Product
- 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL 197376-47-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06
- Product
- 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER 197376-47-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09