ChemicalBook > CAS DataBase List > 3,5-Dichlorobenzoic acid

3,5-Dichlorobenzoic acid

Product Name: 3,5-Dichlorobenzoic acid
CAS No.: 51-36-5
Chemical Name: 3,5-Dichlorobenzoic acid
Synonyms: 3,5-dichlorobenzoic;3.5-Dichlorobe;BUTTPARK 45\07-34;RARECHEM AL BO 0040;3,5-DICHLOROBENZIC ACID;3,5-dichloro-benzoicaci;3,5-Dichlorbenzoesaeure;3,5-DICHLOROBENZOIC ACID;BENZOIC ACID, 3,5-DICHLORO-;3,5-Dichlorobenzoicacid,99%
CBNumber: CB3760057
Molecular Formula: C7H4Cl2O2
Formula Weight: 191.01
MOL File: 51-36-5.mol

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3,5-Dichlorobenzoic acid Property

Melting point:: 184-187 °C (lit.)
Boiling point:: 273.68°C (rough estimate)
Density: 1.4410 (rough estimate)
refractive index: 1.4590 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 3.46±0.10(Predicted)
form: powder to crystal
color: White to Almost white
Water Solubility: 147.1mg/L(temperature not stated)
BRN: 2044776
InChI: InChI=1S/C7H4Cl2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,(H,10,11)
InChIKey: CXKCZFDUOYMOOP-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Cl)=CC(Cl)=C1
CAS DataBase Reference: 51-36-5(CAS DataBase Reference)
NIST Chemistry Reference: 3,5-Dichlorobenzoic acid(51-36-5)
EPA Substance Registry System: 3,5-Dichlorobenzoic acid (51-36-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: DG7350000
HazardClass: IRRITANT
HS Code: 29163990
Toxicity: mouse,LD50,intraperitoneal,237mg/kg (237mg/kg),BEHAVIORAL: REGIDITYBEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY),Journal of Medicinal Chemistry. Vol. 11, Pg. 1020, 1968.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D57507
Product name: 3,5-Dichlorobenzoic acid
Purity: 97%
Packaging: 25g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: D0341
Product name: 3,5-Dichlorobenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: D0341
Product name: 3,5-Dichlorobenzoic Acid
Purity: >98.0%(T)
Packaging: 500g
Price: $370
Updated: 2025/07/31

TRC

Product number: D436563
Product name: 3,5-Dichlorobenzoic Acid
Packaging: 100g
Price: $55
Updated: 2021/12/16

Oakwood

Product number: 005560
Product name: 3,5-Dichlorobenzoic Acid
Purity: 97%
Packaging: 1g
Price: $9
Updated: 2021/12/16

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3,5-Dichlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to beige powder

Physical properties

Crystals of 3,5-dichlorobenzoic acid were obtained from a water/ethanol mixture, mp186–187℃(lit. l85–187℃). Crystallization of 3,5-Dichlorobenzoic acid occurred in the monoclinic centrosymmetric space group P21/n (No. 14) with a = 3.7812(3), b = 13.996(2), and c = 14.514(2) Å, β = 95.183(8); and Z = 4. Chlorine substituents of four dimeric molecules of 3,5-Dichlorobenzoic acid formed square channels, ca. 3.54 Å on a side, which run parallel to the crystallographic a axis.

Uses

3,5-Dichlorobenzoic acid is used in organic synthesis and pesticide and pharmaceutical intermediates. It can be used to synthesize 3,5-Dichloro-N-(4-hydroxyphenethyl)benzamide and (3,5-Dichlorophenyl)-(4-fluorophenyl)methanone.

Definition

ChEBI: 3,5-dichlorobenzoic acid is a chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 3 and 5 are substituted by chloro groups. It has a role as a herbicide and a metabolite. It is a chlorobenzoic acid and a dichlorobenzene. It derives from a benzoic acid. It is a conjugate acid of a 3,5-dichlorobenzoate.

Preparation

Synthesis of 3,5-dichlorobenzoic acid: 200 parts of ethanol is slowly added to a solution, heated to 70°C, of the diazonium salt prepared as described in Example 1 from 412 parts of 3,5-dichloroanthranilic acid; elimination of nitrogen immediately takes place with evolution of heat. The mixture is stirred for another 15 minutes and 350 parts (92% of theory) of 3,5-dichlorobenzoic acid having a melting point of 176° to 178°C is isolated as described in Example 1.

Application

3,5-Dichlorobenzoic acid can be used as a pharmaceutical intermediate compound. Novel cyclopentquinoline and 3,5-dichlorobenzoic acid complexes possess antioxidant and neuroprotective effects, which can be used for the treatment of Alzheimer's disease. In addition, 3,5-Dichlorobenzoic acid has a stimulatory effect on skeletal muscle and can be used in the preparation of benzodiazepine derivatives for treating arrhythmias.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 455, 1951 DOI: 10.1021/ja01145a145

Purification Methods

Crystallise the acid from EtOH and sublime it in a vacuum. [Beilstein 9 IV 1008.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.]

3,5-Dichlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Dicamba 3-Chlorobenzoic acid

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View Lastest Price from 3,5-Dichlorobenzoic acid manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 3,5-Dichlorobenzoic acid 51-36-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-19

RongNa Biotechnology Co.,Ltd

Product: 3,5-Dichlorobenzoic acid 51-36-5
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-21

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Dichlorobenzoic acid 51-36-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-12

51-36-5, 3,5-Dichlorobenzoic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate 4-Nitrobenzoic acid Benzoic acid Estradiol benzoate 1,2-Dichloro-4-(chloromethyl)benzene 4-Aminobenzoic acid Folic acid 4-Hydroxybenzoic acid Citric acid Ascoric Acid 3,4-DICHLOROBENZOIC ACID ETHYL 3,5-DICHLORO-4-HYDROXYBENZOATE Tetrachlorophthalic anhydride Chlorthal Dacthal 3,5-Dichloro-4-hydroxybenzoic acid METHYL 3,5-DICHLORO-4-HYDROXYBENZOATE 2,3-DICHLOROBENZOIC ACID

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51-36-5

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Method 552

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