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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE

Product Name
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
CAS No.
67953-08-6
Chemical Name
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Synonyms
H-GLU(PNA)-OH HCL;GPNA (hydrochloride);gamma-L-Glutamyl-4-nitroanilideHCl;7-bromo-6-oxocholestan-3-yl acetate;gamma-L-Glutamyl-p-nitroanilide HCl;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;n-(4-nitrophenyl)-l-glutaminmonohydrochloride;N-(4-nitrophenyl)-L-glutamine monohydrochloride
CBNumber
CB3779866
Molecular Formula
C11H14ClN3O5
Formula Weight
303.7
MOL File
67953-08-6.mol
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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
Soluble in Water (up to 5 mg/ml).
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
EPA Substance Registry System
L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6133
Product name
L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity
γ-glutamyl transpeptidase substrate
Packaging
1g
Price
$171
Updated
2024/03/01
Sigma-Aldrich
Product number
G6133
Product name
L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity
γ-glutamyl transpeptidase substrate
Packaging
5g
Price
$232.8
Updated
2024/03/01
Sigma-Aldrich
Product number
G6133
Product name
L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity
γ-glutamyl transpeptidase substrate
Packaging
25g
Price
$2030
Updated
2024/03/01
TRC
Product number
G597108
Product name
L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Packaging
100mg
Price
$70
Updated
2021/12/16
Chem-Impex
Product number
00412
Product name
L-Glutamicacidγ-(p-nitroanilide)hydrochloride,99%(HPLC)
Purity
99%(HPLC)
Packaging
1G
Price
$89.6
Updated
2021/12/16
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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Chemical Properties,Usage,Production

Description

L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3

Uses

L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.

References

1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Suppliers

China 44 Germany 1 India 3 Switzerland 2 United Kingdom 2 United States 13 Global 65
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
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View Lastest Price from L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE 67953-08-6
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100 kg
Release date
2020-01-10

67953-08-6, L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDERelated Search:

methyl S-(acetamidomethyl)-L-cysteinate monohydrochloride Polyglutamic acid H-L-Glu-OMe·HCl H-GLU(OBZL)-NH2 HCL H-D-MET-D-MET-OH L-Glutamic acid dimethyl ester hydrochloride L-Glutamic acid 5-methyl ester H-Glu(otBu)-Glu(otBu)-OH H-GLU(OTBU)-NH2 HCL L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride L-Glutamic acid di-tert-butyl ester hydrochloride L-Glutamic acid 5-tert-butyl ester H-Glu(OMe)-OtBu DL-Phe-pNA phenylalanylglycine H-D-GLU(PNA)-OH N-D-Phenylalanyl-D-tryptophan DL-Ornithine hydrochloride

  • H-GLU(PNA)-OH HCL
  • L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE
  • L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE
  • L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
  • GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE
  • l-glutamic acid γ-(p-nitroanilide) hydrochloride
  • L-Glutamic acid g-(p-nitroanilide) hydrochloride
  • L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure
  • (4-amino-1-carboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride
  • (5-amino-1-hydroxy-1,5-dioxopentan-2-yl)-(4-nitrophenyl)azanium chloride
  • L-glutamic acid gamma-(P-nitroanilide)*hydrochlor
  • N-(4-nitrophenyl)-L-glutamine monohydrochloride
  • L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)*H YDROCHLORID
  • gamma-L-Glutamyl-4-nitroanilideHCl
  • n-(4-nitrophenyl)-l-glutaminmonohydrochloride
  • (5-azanyl-1-hydroxy-1,5-dioxo-pentan-2-yl)-(4-nitrophenyl)azanium chloride
  • (3-carbaMoyl-1-carboxy-propyl)-(4-nitrophenyl)azaniuM chloride
  • GPNA (hydrochloride)
  • (S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid hydrochloride
  • 7-bromo-6-oxocholestan-3-yl acetate
  • gamma-L-Glutamyl-p-nitroanilide HCl
  • L-r-Glutamyl-p-Nitroanilide Hydrochloride extrapure, 99%
  • Inhibitor,GGT,SNAT,GPNA,glutamine,lung,inhibit,ASCT2,Gln,Apoptosis,GPNA hydrochloride,γ-glutamyltransferase,LAT,A549,transporter
  • 67953-08-6
  • C11H13N3O5HCl
  • Activity
  • Chromogenic