L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE

Product Name: L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
CAS No.: 67953-08-6
Chemical Name: L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
Synonyms: H-GLU(PNA)-OH HCL;GPNA (hydrochloride);gamma-L-Glutamyl-4-nitroanilideHCl;7-bromo-6-oxocholestan-3-yl acetate;gamma-L-Glutamyl-p-nitroanilide HCl;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;n-(4-nitrophenyl)-l-glutaminmonohydrochloride;N-(4-nitrophenyl)-L-glutamine monohydrochloride
CBNumber: CB3779866
Molecular Formula: C11H14ClN3O5
Formula Weight: 303.7
MOL File: 67953-08-6.mol

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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: Soluble in Water (up to 5 mg/ml).
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
EPA Substance Registry System: L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6133
Product name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity: γ-glutamyl transpeptidase substrate
Packaging: 1g
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6133
Product name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity: γ-glutamyl transpeptidase substrate
Packaging: 5g
Price: $232.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6133
Product name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Purity: γ-glutamyl transpeptidase substrate
Packaging: 25g
Price: $2030
Updated: 2024/03/01

TRC

Product number: G597108
Product name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Packaging: 100mg
Price: $70
Updated: 2021/12/16

Chem-Impex

Product number: 00412
Product name: L-Glutamicacidγ-(p-nitroanilide)hydrochloride,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $89.6
Updated: 2021/12/16

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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Chemical Properties,Usage,Production

Description

L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3

Uses

L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.

References

1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Suppliers

China 44 Germany 1 India 3 Switzerland 2 United Kingdom 2 United States 13 Global 65

TargetMol Chemicals Inc.

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View Lastest Price from L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE 67953-08-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100 kg
Release date: 2020-01-10

67953-08-6, L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDERelated Search:

methyl S-(acetamidomethyl)-L-cysteinate monohydrochloride Polyglutamic acid H-L-Glu-OMe·HCl H-GLU(OBZL)-NH2 HCL H-D-MET-D-MET-OH L-Glutamic acid dimethyl ester hydrochloride L-Glutamic acid 5-methyl ester H-Glu(otBu)-Glu(otBu)-OH H-GLU(OTBU)-NH2 HCL L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride L-Glutamic acid di-tert-butyl ester hydrochloride L-Glutamic acid 5-tert-butyl ester H-Glu(OMe)-OtBu DL-Phe-pNA phenylalanylglycine H-D-GLU(PNA)-OH N-D-Phenylalanyl-D-tryptophan DL-Ornithine hydrochloride

H-GLU(PNA)-OH HCL

L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE

L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE

GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE

l-glutamic acid γ-(p-nitroanilide) hydrochloride

L-Glutamic acid g-(p-nitroanilide) hydrochloride

L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure

(4-amino-1-carboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride

(5-amino-1-hydroxy-1,5-dioxopentan-2-yl)-(4-nitrophenyl)azanium chloride

L-glutamic acid gamma-(P-nitroanilide)*hydrochlor

N-(4-nitrophenyl)-L-glutamine monohydrochloride

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)*H YDROCHLORID

gamma-L-Glutamyl-4-nitroanilideHCl

n-(4-nitrophenyl)-l-glutaminmonohydrochloride

(5-azanyl-1-hydroxy-1,5-dioxo-pentan-2-yl)-(4-nitrophenyl)azanium chloride

(3-carbaMoyl-1-carboxy-propyl)-(4-nitrophenyl)azaniuM chloride

GPNA (hydrochloride)

(S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid hydrochloride

7-bromo-6-oxocholestan-3-yl acetate

gamma-L-Glutamyl-p-nitroanilide HCl

L-r-Glutamyl-p-Nitroanilide Hydrochloride extrapure, 99%

Inhibitor,GGT,SNAT,GPNA,glutamine,lung,inhibit,ASCT2,Gln,Apoptosis,GPNA hydrochloride,γ-glutamyltransferase,LAT,A549,transporter

67953-08-6

C11H13N3O5HCl

Activity

Chromogenic