Marstacimab

Product Name: Marstacimab
CAS No.: 1985638-39-8
Chemical Name: Marstacimab
Synonyms: Marstacimab;Marstacimab (anti-TFPI);Research Grade Marstacimab;Research Grade Marstacimab(DHC82803)
CBNumber: CB38081103
Formula Weight: 0
MOL File: Mol file

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Marstacimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Marstacimab Chemical Properties,Usage,Production

Uses

Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia[1][2].

in vivo

Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models^[2].

Animal Model:	Acute bleeding hemophilia A mouse models^[2]
Dosage:	0.5 mg/kg
Administration:	Intravenous injection, 0.5 mg/kg, once, before tail clip
Result:	Showed no effect on the blood loss compared with control mice, but significantly reduced the blood loss with the combination of aPCC 200 U/kg.

References

[1] Patel-Hett S, et al. Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas. Haemophilia. 2019 Sep;25(5):797-806. DOI:10.1111/hae.13820
[2] Pittman DD, et al. Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model. Res Pract Thromb Haemost. 2022 Mar 16;6(2):e12679. DOI:10.1002/rth2.12679

Marstacimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Marstacimab Suppliers

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1985638-39-8, MarstacimabRelated Search:

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Marstacimab

Research Grade Marstacimab(DHC82803)

Research Grade Marstacimab

Marstacimab (anti-TFPI)

1985638-39-8