Iodoacetic acid

Product Name: Iodoacetic acid
CAS No.: 64-69-7
Chemical Name: Iodoacetic acid
Synonyms: IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
CBNumber: CB3854071
Molecular Formula: C2H3IO2
Formula Weight: 185.95
MOL File: 64-69-7.mol

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Iodoacetic acid Property

Melting point:: 79 °C
Boiling point:: 208°C
Density: 2.2003 (estimate)
Flash point:: 208°C
storage temp.: 2-8°C
solubility: H2O: soluble, clear to hazy
form: Liquid
pka: 3.12(at 25℃)
color: faintly yellow
biological source: synthetic
Water Solubility: 600 g/L (20 ºC)
Sensitive: Light Sensitive
Merck: 14,5025
BRN: 1739079
Stability:: Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
CAS DataBase Reference: 64-69-7(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, iodo-(64-69-7)
EPA Substance Registry System: Iodoacetic acid (64-69-7)

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Safety

Hazard Codes: T,C
Risk Statements: 25-35
Safety Statements: 22-36/37/39-45
RIDADR: UN 2923 8/PG 1
WGK Germany: 1
RTECS: AI3500000
F: 8-9
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29159080
Hazardous Substances Data: 64-69-7(Hazardous Substances Data)
Toxicity: LD50 intravenous in dog: 45mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 10g
Price: $59.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 25g
Price: $110
Updated: 2025/07/31

Sigma-Aldrich

Product number: I4386
Product name: Iodoacetic acid
Purity: ≥98.0% (T)
Packaging: 100g
Price: $334
Updated: 2025/07/31

Usbiological

Product number: 164501
Product name: Iodoacetic Acid
Packaging: 1g
Price: $418
Updated: 2021/12/16

TRC

Product number: I685520
Product name: Iodoacetic acid
Packaging: 1g
Price: $120
Updated: 2021/12/16

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Iodoacetic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.

Uses

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Definition

ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.

General Description

Colorless or white crystals.

Air & Water Reactions

May be sensitive to heat, light, and air. Water soluble

Reactivity Profile

Iodoacetic acid reacts vigorously with bases and is corrosive.

Fire Hazard

Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Purification Methods

Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]

Iodoacetic acid Preparation Products And Raw materials

Raw materials

Chloroacetic acid Copper (II) acetate monohydrate Iodine Acetic acid

Preparation Products

Lornoxicam

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View Lastest Price from Iodoacetic acid manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: Iodoacetic acid 64-69-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-09-24

Hebei Chuanghai Biotechnology Co., Ltd

Product: Iodoacetic acid 64-69-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-14

64-69-7, Iodoacetic acidRelated Search:

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iodoacetic

iodo-aceticaci

Kyselina jodoctova

kyselinajodoctova

monoiodoacetate

RARECHEM AL BO 0101

MONOIODOACETIC ACID

VITAS-BB TBB000669

Aceticacid,iodo-

CH2ICOOH

IA

iodoacetate

IODOACETIC ACID MONO

IODOACETIC ACID

IODOACETIC ACID FREE ACID APPROX 99%,*YE LLOW POWDER

IODOACETIC ACID APPROX. 99% WHITE TO OFF

IODOACETIC ACID R. G.

IodoaceticAcid>99%

IodoaceticAcid97%

IODOACETICACID,REAGENT

Iodoethanoic acid

Iodoacetic acid, 97% 25GR

Iodoacetic acid, >=99.5%

Iodiacetic acid

IODOACETIC ACID, >= 98.0 % (T)

Acetic acid, 2-iodo-

lodoacetic acid

SKL245

Iodoacetic acid, GR 99%

64-69-7

ICH2COOH

ICH2CO2H

C2H3IO2

Synthetic Reagents

Organic Building Blocks

Organic Acids

Puriss p.a.

General Use

Building Blocks

Analytical Reagents

Analytical Chromatography Product Catalog

C1 to C5

Carboxylic Acids

Carbonyl Compounds

Reagents for cysteine modification

Specific Amino Acid Modification

Protein Modification

Analytical Reagents for General Use

I-N, Puriss p.a.

Puriss p.a.

Chemical Synthesis

Organic Acids

Synthetic Reagents

K00001