Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Product Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
CAS No.: 20324-87-2
Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Synonyms: AMI-1;AMI 1;AMI1;AMI-1 disodium salt;AMI-1, 10 mM in DMSO;AMI-1 - AMI-1 sodium salt;J acid urea,disodiuM salt 70%;Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate];AMI 1, protein arginine methyltransferase inhibitor;Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate);SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE;Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)
CBNumber: CB3855058
Molecular Formula: C21H17N2NaO9S2
Formula Weight: 528.48
MOL File: 20324-87-2.mol

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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
form: Brown solid.
color: Light brown to brown
EPA Substance Registry System: 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A576600
Product name: AMI-1(TechnicalGrade)
Packaging: 5mg
Price: $100
Updated: 2021/12/16

TRC

Product number: A576600
Product name: AMI-1(TechnicalGrade)
Packaging: 50mg
Price: $440
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0006664
Product name: DISODIUM 7,7'-(CARBONYLDIIMINO)BIS(4-HYDROXYNAPHTHALENE-2-SULPHONATE)
Purity: 95.00%
Packaging: 5MG
Price: $455
Updated: 2021/12/16

AK Scientific

Product number: A791
Product name: Disodium7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Packaging: 1g
Price: $121
Updated: 2021/12/16

ChemScene

Product number: CS-5013
Product name: AMI-1
Purity: ≥98.0%
Packaging: 25mg
Price: $288
Updated: 2021/12/16

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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties,Usage,Production

Chemical Properties

Light grey paste. Soluble in water and easily soluble in alkaline solution.

Uses

AMI-1 is a Histone Methyltransferase (HMT) inhibitor.

Biological Activity

potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).

in vivo

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo^[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model^[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model^[4].

Animal Model:	6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft^[4]
Dosage:	0.5 mg
Administration:	Intratumorally, daily, for 7 days
Result:	Decreased tumor weight.

IC 50

PRMT1

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Suppliers

China 112 Germany 1 India 2 United Kingdom 1 United States 15 Global 131

Shanghai Boyle Chemical Co., Ltd.

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Spectrum Chemical Manufacturing Corp.

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Dalian Meilun Biotech Co., Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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MedChemexpress LLC

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Nanjing Dulai Biotechnology Co., Ltd.

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Quzhou Juhua Friendship Co., Ltd

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D&C Chemicals

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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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View Lastest Price from Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: AMI 1 20324-87-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-23

Career Henan Chemical Co

Product: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) 20324-87-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

20324-87-2, Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)Related Search:

Ethylenediaminetetraacetic acid disodium salt DIRECT RED 80 Sodium silicate Imidazolidinyl urea CHLOROPHOSPHONAZO III Molasses Folic acid Biuret 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Ethyl 2-(Chlorosulfonyl)acetate ACID RED 66 Sodium formate 1-NAPHTHOL-4-SULFONIC ACID SODIUM SALT Sodium benzoate 8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate Trisodium citrate dihydrate Citric acid Sodium carbonate

4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

AMI-1 - AMI-1 sodium salt

AMI-1;AMI 1;AMI1

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

J acid urea,disodiuM salt 70%

7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate)

Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate]

SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE

AMI-1 disodium salt

Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)

protein arginine N-methyltransferases,AMI 1,Hmt1p,Inhibitor,AMI-1,inhibit,PRMT1,yeast-Hmt1p,AMI1,Histone Methyltransferase,PRMTs

Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)

Disodium 7,7'-(Carbonyldiimino)Bis(4-Hydroxynaphthalené-2-Sulphonate)

AMI 1, protein arginine methyltransferase inhibitor

AMI-1, 10 mM in DMSO

20324-87-2

C21H14N2Na2O9S2

C21H14O9N2S2Na2

C21H14N2O9S2Na2

Inhibitors