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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Product Name
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
CAS No.
20324-87-2
Chemical Name
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Synonyms
AMI-1;AMI 1;AMI1;AMI-1 disodium salt;AMI-1, 10 mM in DMSO;AMI-1 - AMI-1 sodium salt;J acid urea,disodiuM salt 70%;Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate];AMI 1, protein arginine methyltransferase inhibitor;Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate);SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE;Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)
CBNumber
CB3855058
Molecular Formula
C21H17N2NaO9S2
Formula Weight
528.48
MOL File
20324-87-2.mol
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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
form 
Brown solid.
color 
Light brown to brown
EPA Substance Registry System
2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A576600
Product name
AMI-1(TechnicalGrade)
Packaging
5mg
Price
$100
Updated
2021/12/16
TRC
Product number
A576600
Product name
AMI-1(TechnicalGrade)
Packaging
50mg
Price
$440
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0006664
Product name
DISODIUM 7,7'-(CARBONYLDIIMINO)BIS(4-HYDROXYNAPHTHALENE-2-SULPHONATE)
Purity
95.00%
Packaging
5MG
Price
$455
Updated
2021/12/16
AK Scientific
Product number
A791
Product name
Disodium7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Packaging
1g
Price
$121
Updated
2021/12/16
ChemScene
Product number
CS-5013
Product name
AMI-1
Purity
≥98.0%
Packaging
25mg
Price
$288
Updated
2021/12/16
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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties,Usage,Production

Chemical Properties

Light grey paste. Soluble in water and easily soluble in alkaline solution.

Uses

AMI-1 is a Histone Methyltransferase (HMT) inhibitor.

Biological Activity

potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).

in vivo

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].

Animal Model:6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4]
Dosage:0.5 mg
Administration:Intratumorally, daily, for 7 days
Result:Decreased tumor weight.

IC 50

PRMT1

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Suppliers

China 112 Germany 1 India 2 United Kingdom 1 United States 15 Global 131
Eurolabs Limited
Tel
--
Fax
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Country
United Kingdom
ProdList
6309
Advantage
46
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View Lastest Price from Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
AMI 1 20324-87-2
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-23
Career Henan Chemical Co
Product
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) 20324-87-2
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-08

20324-87-2, Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)Related Search:

Ethylenediaminetetraacetic acid disodium salt DIRECT RED 80 Sodium silicate Imidazolidinyl urea CHLOROPHOSPHONAZO III Molasses Folic acid Biuret 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Ethyl 2-(Chlorosulfonyl)acetate ACID RED 66 Sodium formate 1-NAPHTHOL-4-SULFONIC ACID SODIUM SALT Sodium benzoate 8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate Trisodium citrate dihydrate Citric acid Sodium carbonate

  • 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
  • AMI-1 - AMI-1 sodium salt
  • AMI-1;AMI 1;AMI1
  • disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate
  • disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
  • disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
  • J acid urea,disodiuM salt 70%
  • 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt
  • Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
  • Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate)
  • Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate]
  • SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE
  • AMI-1 disodium salt
  • Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)
  • protein arginine N-methyltransferases,AMI 1,Hmt1p,Inhibitor,AMI-1,inhibit,PRMT1,yeast-Hmt1p,AMI1,Histone Methyltransferase,PRMTs
  • Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)
  • Disodium 7,7'-(Carbonyldiimino)Bis(4-Hydroxynaphthalené-2-Sulphonate)
  • AMI 1, protein arginine methyltransferase inhibitor
  • AMI-1, 10 mM in DMSO
  • 20324-87-2
  • C21H14N2Na2O9S2
  • C21H14O9N2S2Na2
  • C21H14N2O9S2Na2
  • Inhibitors