Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Product Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
CAS No.: 20324-87-2
Chemical Name: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Synonyms: AMI-1;AMI 1;AMI1;AMI-1 disodium salt;AMI-1, 10 mM in DMSO;AMI-1 - AMI-1 sodium salt;J acid urea,disodiuM salt 70%;Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate];AMI 1, protein arginine methyltransferase inhibitor;Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate);SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE;Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)
CBNumber: CB3855058
Molecular Formula: C21H17N2NaO9S2
Formula Weight: 528.48
MOL File: 20324-87-2.mol

More

Less

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
form: Brown solid.
color: Light brown to brown
EPA Substance Registry System: 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A576600
Product name: AMI-1(TechnicalGrade)
Packaging: 5mg
Price: $100
Updated: 2021/12/16

TRC

Product number: A576600
Product name: AMI-1(TechnicalGrade)
Packaging: 50mg
Price: $440
Updated: 2021/12/16

Oakwood

Product number: 094733
Product name: Disodium4-Hydroxy-7-{[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoyl]amino}naphthaleyl)carbamoyl]amino}naphthalene-2-sulfonate
Purity: tech
Packaging: 1g
Price: $53
Updated: 2021/12/16

ApexBio Technology

Product number: A1908
Product name: AMI-1
Packaging: 5mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: A791
Product name: Disodium7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Packaging: 1g
Price: $121
Updated: 2021/12/16

More

Less

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties,Usage,Production

Chemical Properties

Light grey paste. Soluble in water and easily soluble in alkaline solution.

Uses

AMI-1 is a Histone Methyltransferase (HMT) inhibitor.

Biological Activity

potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).

in vivo

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo^[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model^[4].
? AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model^[4].

Animal Model:	6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft^[4]
Dosage:	0.5 mg
Administration:	Intratumorally, daily, for 7 days
Result:	Decreased tumor weight.

IC 50

PRMT1

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Suppliers

China 112 Germany 1 India 2 United Kingdom 1 United States 15 Global 131

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Abcam Limited

Tel: --
Fax: --
Email: us.orders@abcam.com
Country: United States
ProdList: 6001
Advantage: 50

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

More

Less

View Lastest Price from Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: AMI 1 20324-87-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-23

Career Henan Chemical Co

Product: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) 20324-87-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

20324-87-2, Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)Related Search:

Ethylenediaminetetraacetic acid disodium salt DIRECT RED 80 Sodium silicate Imidazolidinyl urea CHLOROPHOSPHONAZO III Molasses Folic acid Biuret 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Ethyl 2-(Chlorosulfonyl)acetate ACID RED 66 Sodium formate 1-NAPHTHOL-4-SULFONIC ACID SODIUM SALT Sodium benzoate 8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate Trisodium citrate dihydrate Citric acid Sodium carbonate

4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

AMI-1 - AMI-1 sodium salt

AMI-1;AMI 1;AMI1

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate

J acid urea,disodiuM salt 70%

7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate)

Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate]

SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE

AMI-1 disodium salt

Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)

protein arginine N-methyltransferases,AMI 1,Hmt1p,Inhibitor,AMI-1,inhibit,PRMT1,yeast-Hmt1p,AMI1,Histone Methyltransferase,PRMTs

Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)

Disodium 7,7'-(Carbonyldiimino)Bis(4-Hydroxynaphthalené-2-Sulphonate)

AMI 1, protein arginine methyltransferase inhibitor

AMI-1, 10 mM in DMSO

20324-87-2

C21H14N2Na2O9S2

C21H14O9N2S2Na2

C21H14N2O9S2Na2

Inhibitors